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公开(公告)号：US20220339291A1
公开(公告)日：2022-10-27
申请号：US16964965
申请日：2020-03-05
发明人： Chang Sik Park , Min Ji Choi , Tae Ik Jang , Yun-Hee Park , Ho Young Song , Ju Yuel Baek , Sung Min Kim , Hyeun Joung Lee , Ju Young Lee , Hyoung Rae Kim , Kun Jung Lee , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Sang Pil Lee , Ji-Young Shin , Sunha Yoon , Yunseon Choi , Jae Eun Park , Jisu Lee , Bum-Chan Park , Young Woo Park
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting DLK1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically, uses for such ADCs in producing drugs for treatment and/or prevention of proliferative and/or angiogenetic diseases, for example, cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding with DLK1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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2.发明申请公开(公告)号：US20200172542A1
公开(公告)日：2020-06-04
申请号：US16783893
申请日：2020-02-06
发明人： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC分类号： C07D471/04 , C07D498/10 , C07D519/00 , C07D471/10 , C07D413/14 , C07D413/12 , C07D403/14 , C07D401/14 , C07D513/04
摘要： The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.
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公开(公告)号：US20180353611A1
公开(公告)日：2018-12-13
申请号：US16005245
申请日：2018-06-11
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jung Un Cho , Doo Hwan Jung , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Jeon Yang
IPC分类号： A61K47/68 , C07K19/00 , C07K16/32 , C07D519/00 , C07D487/04 , C07D249/04 , A61K47/54 , A61K47/69 , A61K39/00
CPC分类号： A61K47/6871 , A61K47/50 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24 , C07K2317/94
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US09919057B2
公开(公告)日：2018-03-20
申请号：US14865778
申请日：2015-09-25
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC分类号： C07D309/10 , A61K47/48 , C07D249/04 , C07K19/00
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
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公开(公告)号：US20160184451A1
公开(公告)日：2016-06-30
申请号：US14865778
申请日：2015-09-25
发明人： Yong Zu Kim , Tae Kyo Park , Sung Ho Woo , Sun Young Kim , Jong Un Cho , Doo Hwan Jung , Jeon Yang , Ji Young Min , Hyang Sook Lee , Yun Hee Park , Jeong Hee Ryu , Kyu Man Oh , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung
IPC分类号： A61K47/48
CPC分类号： A61K47/6871 , A61K47/549 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6813 , A61K47/6855 , A61K47/6889 , A61K47/69 , A61K2039/505 , C07D249/04 , C07D487/04 , C07D519/00 , C07K16/32 , C07K19/00 , C07K2317/24
摘要： Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.
摘要翻译： 本发明提供的是包含自褪色基团的化合物，并且包含本发明的自褪色组的化合物可以包括具有底物特异性的蛋白质（例如寡肽，多肽，抗体等） 具有特定功能或活性的靶和活性剂（例如药物，毒素，配体，检测探针等）。
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公开(公告)号：US20230123569A1
公开(公告)日：2023-04-20
申请号：US18073120
申请日：2022-12-01
发明人： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC分类号： C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
摘要： The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
公开(公告)号：US11548883B2
公开(公告)日：2023-01-10
申请号：US16098748
申请日：2018-05-15
发明人： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC分类号： C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
摘要： The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
公开(公告)号：US11413353B2
公开(公告)日：2022-08-16
申请号：US15779446
申请日：2016-11-23
发明人： Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae , Ho Young Song , Chul-Woong Chung , Yun Hee Park , Hyo Jung Choi , Kyung Eun Park , Hyoungrae Kim , Jinyeong Kim , Ji Young Min , Sung Min Kim , Byung Soo Lee , Dong Hyun Woo , Ji Eun Jung , Su In Lee
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：US20170088614A1
公开(公告)日：2017-03-30
申请号：US15276209
申请日：2016-09-26
发明人： Yong Zu Kim , Yun Hee Park , Jeong Hee Ryu , Ho Young Song , Jeiwook Chae , Chul-Woong Chung , Ji Eun Jung , Hyo Jung Choi
CPC分类号： C07K16/2803 , A61K31/351 , A61K47/6803 , A61K47/6831 , A61K47/6849 , A61K47/6889 , A61K2039/505 , C07D301/10 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C07K2317/94 , Y02A50/475
摘要： In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
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公开(公告)号：US11707533B2
公开(公告)日：2023-07-25
申请号：US16940326
申请日：2020-07-27
发明人： Yun-Hee Park , Ho Young Song , Hyun Min Ryu , Sung Min Kim , Ju Yuel Baek , Ji Hye Oh , Nara Han , Hyoung Rae Kim , Kyung Eun Park , Hyeun Joung Lee , Ju Young Lee , Dae Hyuck Kang , Young-Jae Yang , Ji-Na You , Yong Zu Kim , Chang Sun Lee , Jeiwook Chae , Jinwon Jung , Juhee Kim , Bora Lee , Daehae Song , Byungje Sung , Donghoon Yeom , Jaehyun Eom , Youngeun Hong , Jinhyung Ahn , Yangsoon Lee , Kyungjin Park , Jiseon Yoo , Minji Park
CPC分类号： A61K47/6849 , A61K47/6803 , A61P35/00 , C07K16/2803
摘要： The present invention relates to new antibody-drug conjugates (ADCs) targeting ROR1, active metabolites of such ADCs, methods for preparation of such ADCs, uses for such ADCs in treatment and/or prevention of illnesses, and uses for such ADCs in production of drugs for treatment and/or prevention of diseases, more specifically diseases associated with over-expression of ROR1, for example cancer. More specifically, the present invention relates to an antibody-drug conjugate comprising an antibody that binds to ROR1 or an antigen-binding fragment thereof, and a pharmaceutical composition comprising the same.
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