公开(公告)号：US20140378917A1

公开(公告)日：2014-12-25

申请号：US14368864

申请日：2012-12-28

Applicant: UCB Pharma GmbH ,  LTS LOHMANN THERAPIE SYSTEME AG

Inventor： Horst Dzekan ,  Hans-Rainer Hoffmann ,  Michael Horstmann ,  Walter Mueller ,  Sandra Wiedersberg

IPC: A61K9/70 ,  A61K31/381 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/439 ,  A61K31/485 ,  A61K31/325

Abstract: The present invention provides transdermal therapeutic systems for dispensing a pharmaceutical product, in particular a pharmaceutical product with a low tendency to spontaneously crystallize. The matrix layer or at least one of the matrix layers in said systems contains a silicone hot-melt adhesive, a pharmaceutical product, and particles made of crosslinked polyvinylpyrrolidone. The invention also relates to a method for producing said transdermal therapeutic systems.

Abstract translation: 本发明提供用于分配药物产品，特别是具有低自发结晶倾向的药物产品的透皮治疗系统。 所述系统中的基质层或基质层中的至少一个包含硅氧烷热熔粘合剂，药物产品和由交联聚乙烯吡咯烷酮制成的颗粒。 本发明还涉及一种生产所述透皮治疗系统的方法。