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公开(公告)号：US20090036861A1
公开(公告)日：2009-02-05
申请号：US12183585
申请日：2008-07-31
IPC分类号： A61J1/14
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
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公开(公告)号：US09186170B2
公开(公告)日：2015-11-17
申请号：US12466130
申请日：2009-05-14
IPC分类号： A61B17/22 , A61B17/3207 , A61B17/32
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/320004
摘要： A rotational atherectomy device that includes an expandable head that can clean a blockage from vessel larger than its rest diameter, in which the drive shaft may rotate in two opposite directions and may have different abrasive characteristics for each rotation direction. In one direction, the head may be configured for cutting and/or slicing, which may be well suited to removing particularly soft blockage material. In the other direction, the head may be configured for grinding, scraping and/or sanding, which may be well suited to removing particularly hard blockage material. The head includes one or more arms that are pivotally or hingedly attached to the drive shaft. One or more abrasive elements are disposed on or are attached to the one or more arms. The abrasive elements have a cutting feature, such as a sharpened edge that cuts like a razor blade when the drive shaft is rotated in the “cutting” direction. The abrasive elements also have a grinding feature, such as an abrasive material disposed on the abrasive element adjacent to the sharpened edge, which grinds away a blockage when the drive shaft is rotated in the “grinding” direction.
摘要翻译： 一种旋转粥样斑块切除装置，其包括可以从容器清洁大于其静止直径的阻塞的可扩张头部，其中驱动轴可沿两个相反的方向旋转，并且可以对于每个旋转方向具有不同的研磨特性。 在一个方向上，头部可以被配置用于切割和/或切片，其可以非常适合于去除特别柔软的阻塞材料。 在另一个方向上，头可以被配置用于研磨，刮擦和/或打磨，这可能非常适合于去除特别硬的堵塞材料。 头包括一个或多个枢转地或铰接地附接到驱动轴的臂。 一个或多个研磨元件设置在一个或多个臂上或附接到一个或多个臂。 研磨元件具有切割特征，例如当驱动轴沿“切割”方向旋转时切割成剃刀刀片的锋利边缘。 研磨元件还具有研磨特征，例如设置在与磨边相邻的研磨元件上的研磨材料，当磨削轴沿“研磨”方向旋转时，其研磨堵塞。
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公开(公告)号：US20140001063A1
公开(公告)日：2014-01-02
申请号：US13537363
申请日：2012-06-29
IPC分类号： B65D25/04
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/2041 , A61J1/2055
摘要： A port assembly for connecting a first container to a second container and mixing the contents of the first container with the contents of the second container. The port assembly has a port housing that is configured to receive a first container. The port assembly further includes an actuator axially fixed within a cavity of the port housing. The actuator is configured to open the first container by forcing a stopper sealing an opening of the first container into a cavity of the first container during activation.
摘要翻译： 一种用于将第一容器连接到第二容器并将第一容器的内容物与第二容器的内容物混合的端口组件。 端口组件具有端口壳体，其构造成接收第一容器。 端口组件还包括轴向固定在端口壳体的空腔内的致动器。 致动器构造成通过在启动期间迫使将第一容器的开口密封到第一容器的空腔中的止动件来打开第一容器。
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公开(公告)号：US20090277347A1
公开(公告)日：2009-11-12
申请号：US12396928
申请日：2009-03-03
IPC分类号： B41F17/00
CPC分类号： B41F17/001
摘要： An auto alignment pad printer for transferring print to an associated object includes a frame, a fixture for supporting the associated object and a cliché operably mounted to the frame. The cliché includes at least one etched region and is adapted to receive ink in the etched region. An ink cup is configured to deposit ink into the etched region. A pad applicator includes a pad support having at least one pad thereon. The pad is adapted to move into and out of contact with the etched region to receive ink from the etched region and to contact an object to transfer the received ink to the object. A pad applicator alignment assembly includes a first set of cooperating projections and receivers mounted to the pad applicator and to the cliché and/or the frame near to the cliché, and a second set of cooperating projections and receivers mounted to the pad applicator and to the fixture for supporting the object. The first set of cooperating projections and receivers are configured to position the pad for precise movement into contact with the cliché to receive ink from the cliché. The second set of cooperating projections and receivers are configured to position the pad for precise movement into contact with the object to transfer the received ink to the associated object.
摘要翻译： 用于将打印件转印到相关对象的自动对准打印机打印机包括框架，用于支撑相关联对象的固定装置和可操作地安装到框架上的陈词滥调。 陈设包括至少一个蚀刻区域，并且适于在蚀刻区域中接收墨水。 油墨杯配置成将油墨沉积到蚀刻区域中。 衬垫施加器包括其上具有至少一个垫的衬垫支撑件。 衬垫适于移动进入和离开与蚀刻区域的接触以从蚀刻区域接收墨水并接触物体以将接收的墨水转移到物体。 垫敷贴器对准组件包括第一组配合的突起和接收器，其安装到衬垫施用器和靠近底板的桌面和/或框架，以及第二组协作的突出和接收器，安装到衬垫施用器 夹具用于支撑物体。 第一组配合的投影和接收器被配置成定位垫以精确地移动与陈词滥调接触，以从陈词滥调中接收墨。 第二组配合的投影和接收器被配置成定位垫以精确地移动与物体接触，以将接收到的墨转移到相关联的物体。
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公开(公告)号：US20090036864A1
公开(公告)日：2009-02-05
申请号：US12183716
申请日：2008-07-31
IPC分类号： A61J1/14
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
摘要翻译： 用于将包含在第一容器中的药物与包含在第二容器中的稀释剂或流体混合或重构的系统。 第二容器具有用于接合第一容器的端口对接组件。 第一容器在端口对接组件内可旋转并可轴向滑动。 端口对接组件具有致动器以促使止动器将第一容器流体地密封到第一容器的内部。 端口对接组件还包括可移动插塞，其构造成将第二容器流体地密封在第一对接位置中并且在第二致动位置中提供对第二容器内部的通路，由此第一和第二容器之间的流体连通是 当第一和第二容器处于第二激活位置时。
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16.发明授权Atherectomy device, system and method having a bi-directional distal expandable ablation element 有权具有双向远端可扩展消融元件的粥样斑块切除装置，系统和方法公开(公告)号：US08795304B2
公开(公告)日：2014-08-05
申请号：US12817354
申请日：2010-06-17
IPC分类号： A61B17/22 , A61B17/32 , A61B17/3207
CPC分类号： A61B17/320758 , A61B17/32075 , A61B2017/320028 , A61B2017/320775
摘要： The invention provides a rotational atherectomy system, device and method comprising a bi-directional drive shaft with a flexible ablation element disposed at the distal end of the drive shaft. The flexible ablation element comprises a first retracted position for insertion into vasculature and a second expanded position for ablation, i.e., cutting, sanding and/or grinding. The ablation element comprises more than one flexible finger or blade which allows changing, in certain embodiments, of curvature radius to fit inside a deployment catheter and/or enlarge to the diameter of larger lumens, up to at least 9 mm in diameter. Bi-directional rotation of the expanded ablation element allows cutting in one rotational direction and grinding and/or sanding in the opposite rotational direction.
摘要翻译： 本发明提供了一种旋转粥样斑块切除系统，装置和方法，其包括双向驱动轴，其具有设置在驱动轴的远端处的柔性消融元件。 柔性消融元件包括用于插入脉管系统的第一缩回位置和用于消融的第二扩展位置，即切割，打磨和/或研磨。 消融元件包括多于一个的柔性指状物或刀片，其允许在某些实施例中改变曲率半径以配合在展开导管内部和/或扩大到直径至少为9mm的较大腔的直径。 扩展的消融元件的双向旋转允许沿一个旋转方向进行切割，并在相反的旋转方向进行研磨和/或打磨。
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17.发明授权Therapeutic agent delivery system, device and method for localized application of therapeutic substances to a biological conduit 失效用于将治疗物质局部应用于生物导管的治疗剂递送系统，装置和方法公开(公告)号：US08551130B2
公开(公告)日：2013-10-08
申请号：US13027391
申请日：2011-02-15
IPC分类号： A61B17/22
CPC分类号： A61B17/320758 , A61B2017/320004 , A61B2017/320766 , A61M11/006 , A61M2025/105 , A61M2205/103
摘要： The invention provides a system, device and method for localized application of therapeutic substances within a biological conduit. One embodiment comprises a rotational atherectomy device having a flexible, elongated, rotatable, drive shaft having a lumen and with an eccentric enlarged abrading head having at least one application hole attached therethrough and in communication with a therapeutic agent delivery sheath and an operator-controlled actuator. The therapeutic substances may then spray radially outwardly from the application hole(s) on the eccentric abrading head during and/or after high-speed rotation of the head. Another embodiment comprises compartments in the abrading head that hold therapeutic agent(s) for release during high-speed rotation. In each case, the therapeutic substance(s) is delivered with radial forces resulting from high-speed orbital rotation of the eccentric abrading head, driving the therapeutic substance(s) into the conduit wall.
摘要翻译： 本发明提供了一种用于在生物导管内局部应用治疗物质的系统，装置和方法。 一个实施例包括具有柔性，细长的，可旋转的驱动轴的旋转粥样斑块切除装置，所述驱动轴具有内腔和具有附接穿过其中的至少一个施加孔并与治疗剂输送护套和操作者控制致动器连通的偏心扩大研磨头 。 然后，治疗物质可以在头部高速旋转期间和/或之后从偏心研磨头上的施加孔径向向外喷射。 另一个实施例包括在高速旋转期间保持用于释放的治疗剂的研磨头中的隔室。 在每种情况下，治疗物质以由偏心研磨头的高速轨道旋转产生的径向力输送，将治疗物质驱动到导管壁中。
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公开(公告)号：US08216207B2
公开(公告)日：2012-07-10
申请号：US12183716
申请日：2008-07-31
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
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公开(公告)号：US20090306689A1
公开(公告)日：2009-12-10
申请号：US12466130
申请日：2009-05-14
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/320004
摘要： A rotational atherectomy device that includes an expandable head that can clean a blockage from vessel larger than its rest diameter, in which the drive shaft may rotate in two opposite directions and may have different abrasive characteristics for each rotation direction. In one direction, the head may be configured for cutting and/or slicing, which may be well suited to removing particularly soft blockage material. In the other direction, the head may be configured for grinding, scraping and/or sanding, which may be well suited to removing particularly hard blockage material. The head includes one or more arms that are pivotally or hingedly attached to the drive shaft. One or more abrasive elements are disposed on or are attached to the one or more arms. The abrasive elements have a cutting feature, such as a sharpened edge that cuts like a razor blade when the drive shaft is rotated in the “cutting” direction. The abrasive elements also have a grinding feature, such as an abrasive material disposed on the abrasive element adjacent to the sharpened edge, which grinds away a blockage when the drive shaft is rotated in the “grinding” direction.
摘要翻译： 一种旋转粥样斑块切除装置，其包括可以从容器清洁大于其静止直径的阻塞的可扩张头部，其中驱动轴可沿两个相反的方向旋转，并且可以对于每个旋转方向具有不同的研磨特性。 在一个方向上，头部可以被配置用于切割和/或切片，其可以非常适合于去除特别柔软的阻塞材料。 在另一个方向上，头可以被配置用于研磨，刮擦和/或打磨，这可能非常适合于去除特别硬的堵塞材料。 头包括一个或多个枢转地或铰接地附接到驱动轴的臂。 一个或多个研磨元件设置在一个或多个臂上或附接到一个或多个臂。 研磨元件具有切割特征，例如当驱动轴沿“切割”方向旋转时切割成剃刀刀片的锋利边缘。 研磨元件还具有研磨特征，例如设置在与磨边相邻的研磨元件上的研磨材料，当磨削轴沿“研磨”方向旋转时，其研磨堵塞。
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公开(公告)号：US20090036866A1
公开(公告)日：2009-02-05
申请号：US12184005
申请日：2008-07-31
IPC分类号： A61J1/20
CPC分类号： A61J1/2093 , A61J1/10 , A61J1/1462 , A61J1/1475 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2089 , A61M2039/0036 , B65B3/003 , B65D51/002 , B65D75/5883 , B65D81/3211
摘要： A system for mixing or reconstituting a drug contained in a first container with a diluent or fluid contained in a second container. The second container has a port docking assembly for engaging the first container. The first container is rotatable and axially slidable within the port docking assembly. The port docking assembly has an actuator to urge a stopper fluidly sealing the first container into the interior of the first container. The port docking assembly further includes a movable plug constructed to fluidly seal the second container in a first, docked position and to provide access to the interior of the second container in a second, activated position, whereby fluid communication between the first and second containers is provided when the first and second containers are in the second, activated position.
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