公开(公告)号：US08431585B2

公开(公告)日：2013-04-30

申请号：US12706819

申请日：2010-02-17

申请人： Thomas Singer ,  Stefan Platz ,  Florian Colbatzky

发明人： Thomas Singer ,  Stefan Platz ,  Florian Colbatzky

IPC分类号： A61K31/517

CPC分类号： A61K31/517 ,  A61K31/47 ,  A61K31/519

摘要： The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions.

公开(公告)号：US07989474B2

公开(公告)日：2011-08-02

申请号：US12334323

申请日：2008-12-12

申请人： Gerald Juergen Roth ,  Armin Heckel ,  Rainer Walter ,  Frank Hilberg ,  Rudolf Hauptmann ,  Martin Fredrich Stefanic ,  Florian Colbatzky ,  Steffan Ernest

发明人： Gerald Juergen Roth ,  Armin Heckel ,  Rainer Walter ,  Frank Hilberg ,  Rudolf Hauptmann ,  Martin Fredrich Stefanic ,  Florian Colbatzky ,  Steffan Ernest

IPC分类号： A61K31/445

CPC分类号： A61K45/06 ,  A61K31/404 ,  A61K31/454 ,  A61K31/517 ,  A61K2300/00

摘要： The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

摘要翻译： 本发明涉及一种治疗免疫学疾病或病理状态的方法，该方法使用已知的用作肿瘤学治疗的激酶抑制剂的某些Lck抑制剂，任选与一种或多种其它选自NSAID，类固醇，DMARD，免疫抑制剂， 生物反应调节剂和抗感染剂，包含所述Lck抑制剂与所述其它药物的药物组合物，以及使用Lck抑制剂制备用于治疗免疫学疾病或涉及免疫组分的病理状况的药物组合物。

公开(公告)号：US20050137233A1

公开(公告)日：2005-06-23

申请号：US11056029

申请日：2005-02-11

申请人： Norbert Hauel ,  Florian Colbatzky ,  Ulrich Busch

发明人： Norbert Hauel ,  Florian Colbatzky ,  Ulrich Busch

IPC分类号： A61K31/4439 ,  A61P7/02 ,  A61P43/00 ,  C07D401/12 ,  C07D43/02

CPC分类号： C07D401/12

摘要： The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.

公开(公告)号：US20090306104A1

公开(公告)日：2009-12-10

申请号：US12541961

申请日：2009-08-16

申请人： Gerald Juergen Roth ,  Armin Heckel ,  Rainer Walter ,  Frank Hilberg ,  Rudolf Hauptmann ,  Martin Fredrich Stefanic ,  Florian Colbatzky ,  Steffan Ernest

发明人： Gerald Juergen Roth ,  Armin Heckel ,  Rainer Walter ,  Frank Hilberg ,  Rudolf Hauptmann ,  Martin Fredrich Stefanic ,  Florian Colbatzky ,  Steffan Ernest

IPC分类号： A61K31/404 ,  A61K31/454 ,  A61K31/517 ,  A61P37/00 ,  A61P29/00

CPC分类号： A61K45/06 ,  A61K31/404 ,  A61K31/454 ,  A61K31/517 ,  A61K2300/00

摘要： The invention relates to a method of treating immunologic diseases or pathological conditions involving an immunologic component using certain Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressives, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said Lck inhibitors together with said other drugs, and the use of the Lck inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

公开(公告)号：US20070099918A1

公开(公告)日：2007-05-03

申请号：US11609407

申请日：2006-12-12

申请人： Thomas Singer ,  Stefan Platz ,  Florian Colbatzky

发明人： Thomas Singer ,  Stefan Platz ,  Florian Colbatzky

IPC分类号： A61K31/5377 ,  A61K31/517

CPC分类号： A61K31/517 ,  A61K31/47 ,  A61K31/519

摘要： The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions.

摘要翻译： 本发明涉及特异性EGF受体拮抗剂用于制备预防和/或治疗良性前列腺增生和/或前列腺肥大的药物组合物的用途，治疗或预防良性前列腺增生/前列腺肥大的方法，其包括 施用本文所述的组（A），（B）或（C）组的EGF受体拮抗剂，任选与已知化合物组合用于治疗良性前列腺增生/前列腺肥大，以及相关药物组合物。

公开(公告)号：US07189743B2

公开(公告)日：2007-03-13

申请号：US11056029

申请日：2005-02-11

申请人： Norbert Hauel ,  Florian Colbatzky ,  Ulrich Busch

发明人： Norbert Hauel ,  Florian Colbatzky ,  Ulrich Busch

IPC分类号： A61K31/44

CPC分类号： C07D401/12

摘要： The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.

摘要翻译： 本发明涉及具有凝血酶抑制活性的新型通式化合物。 示例性的是：1-甲基-2- [4-（N-羟基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-乙氧基羰基乙基） - 酰胺和1-甲基 -2- [4-（N-甲氧基羰基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-羟基羰基乙基） - 酰胺。