公开(公告)号：US20170197953A1

公开(公告)日：2017-07-13

申请号：US15312839

申请日：2015-05-22

申请人： MERCK SHARP &DOHME CORP.

发明人： Weiguo Liu ,  Scott D. Edmondson ,  Zhuyan Guo ,  Eric Mertz ,  Anthony K. Ogawa ,  Sung-Sau So ,  Wanying Sun ,  Linda L. Brockunier ,  Amjad Ali ,  Rongze Kuang ,  Heping Wu

IPC分类号： C07D417/10 ,  C07D413/10 ,  C07D401/12 ,  C07D401/14 ,  C07D401/10 ,  C07D213/89

CPC分类号： C07D417/10 ,  C07D213/89 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D413/10

摘要： The present invention provides a compound of Formula I (The chemical formula should be inserted here.) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.