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公开(公告)号：US20110245501A1
公开(公告)日：2011-10-06
申请号：US13160027
申请日：2011-06-14
Applicant: Michael Draper , Mark L. Nelson
Inventor： Michael Draper , Mark L. Nelson
IPC: C07D295/155 , C07D307/81 , C07C237/26 , C07D307/54 , C07D277/42 , C07D213/56
CPC classification number: A61K45/06 , A61K31/65 , A61K31/7048 , A61K2300/00
Abstract: The present invention relates to substituted tetracycline compounds and related methods for increasing the antifungal activity of an antifungal agent. The methods include administering to a subject an effective amount of a substituted tetracycline compound in combination with an antifungal agent such that the subject is treated for the fungal associated disorder.
Abstract translation: 本发明涉及取代的四环素化合物以及提高抗真菌剂抗真菌活性的相关方法。 所述方法包括向受试者施用有效量的取代的四环素化合物与抗真菌剂的组合，使得受试者被治疗用于真菌相关病症。
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公开(公告)号：US07960366B2
公开(公告)日：2011-06-14
申请号：US10943571
申请日：2004-09-16
Applicant: Michael Draper , Mark L. Nelson
Inventor： Michael Draper , Mark L. Nelson
CPC classification number: A61K45/06 , A61K31/65 , A61K31/7048 , A61K2300/00
Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.
Abstract translation: 讨论了用于治疗真菌相关疾病的协同治疗的方法和组合物。
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13.发明授权公开(公告)号：US07935687B2
公开(公告)日：2011-05-03
申请号：US12102623
申请日：2008-04-14
Applicant: Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
Inventor： Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
IPC: A61K31/835 , A61K31/16
CPC classification number: A61K31/65
Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
Abstract translation: 描述了使用四环素化合物治疗脊髓性肌萎缩的方法。
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14.发明申请Substituted Tetracycline Compounds for Treatment of Inflammatory Skin Disorders 有权用于治疗炎症性皮肤病的取代四环素化合物公开(公告)号：US20080312193A1
公开(公告)日：2008-12-18
申请号：US11963509
申请日：2007-12-21
Applicant: Haregewein Assefa , Beena Bhatia , Michael Draper , Laura Honeyman , Oak K. Kim , Dennis P. Molnar
Inventor： Haregewein Assefa , Beena Bhatia , Michael Draper , Laura Honeyman , Oak K. Kim , Dennis P. Molnar
IPC: A61K31/65 , A61P29/00 , C07C237/26
CPC classification number: C07C237/48 , A61K31/65 , C07C237/26 , C07C2103/46 , C07C2603/46
Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.
Abstract translation: 描述了用于治疗皮肤病症（例如痤疮，红斑痤疮）的方法和组合物。
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15.发明申请公开(公告)号：US20140274566A1
公开(公告)日：2014-09-18
申请号：US13833833
申请日：2013-03-15
Applicant: Michael Draper , Johnnie Paulus
Inventor： Michael Draper , Johnnie Paulus
IPC: A63B24/00
CPC classification number: A63B24/0062 , A63B21/00181 , A63B21/0058 , A63B21/0628 , A63B21/154 , A63B21/4043 , A63B23/03525 , A63B23/1209 , A63B24/0087 , A63B2024/0093
Abstract: A system and process that selectively provides lifting assistance during the concentric phase and possibly during the eccentric phase during lifting of weights for rehabilitation or training, the system being programmable to provide a variety of exercise programs dedicated to a particular user, and the system monitoring the progress of the user during the exercise to selectively respond to certain trigger conditions.
Abstract translation: 一种系统和过程，该系统和过程在提升用于康复或训练的重量期间在同心相期间以及可能在偏心阶段期间选择性地提供起重辅助，所述系统可编程以提供专用于特定用户的各种运动程序，并且系统监视 运动期间用户的进展以选择性地响应某些触发条件。
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Patent Agency Ranking
16.发明申请公开(公告)号：US20110207706A1
公开(公告)日：2011-08-25
申请号：US13099993
申请日：2011-05-03
Applicant: Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
Inventor： Joel Berniac , Todd Bowser , Michael Draper , Stuart B. Levy , Mark L. Nelson
CPC classification number: A61K31/65
Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
Abstract translation: 描述了使用四环素化合物治疗脊髓性肌萎缩的方法。
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17.发明申请Methods of regulating expression of genes or of gene products using substituted tetracycline compounds 审中-公开使用取代的四环素化合物调节基因或基因产物表达的方法公开(公告)号：US20080118979A1
公开(公告)日：2008-05-22
申请号：US11803854
申请日：2007-05-15
Applicant: Michael Draper , Mark L. Nelson
Inventor： Michael Draper , Mark L. Nelson
IPC: C12N5/02
CPC classification number: C12N15/635 , A61K31/65 , C12N15/85 , C12N2830/003
Abstract: The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.
Abstract translation: 本发明至少部分地涉及取代的四环素化合物用于调节与四环素操作系统可操作地连接的核酸表达的用途。 本发明涉及利用原核生物的Tet阻遏物/操纵子/诱导物系统的组分调节细胞中基因表达的调节系统中使用的化合物。 与本发明方法中所特征的某些取代的四环素化合物的使用相比，与例如四环素和多西环素相比，导致改善的剂量反应结果。 因此，本发明的某些方法允许增强Tet阻遏物/操纵子/诱导物系统在调节细胞中的基因表达方面的控制。
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公开(公告)号：US20070184206A1
公开(公告)日：2007-08-09
申请号：US10550421
申请日：2004-03-18
Applicant: Michael Draper
Inventor： Michael Draper
IPC: D21F1/00
CPC classification number: D21F1/0027 , D21F7/08
Abstract: The present invention relates to a method of making an industrial fabric comprising the following steps: -applying a radiation-curable powder onto the surface of a fabric, melting the powder such that the powder forms a layer on the fabric surface and directing radiation at said surface layer so as to cure the constituent material of said coating layer.
Abstract translation: 本发明涉及一种制造工业织物的方法，其包括以下步骤：将可辐射固化的粉末施加到织物的表面上，使粉末熔化，使得粉末在织物表面上形成一层，并引导在所述织物表面上的辐射 表面层，以固化所述涂层的构成材料。
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公开(公告)号：US20060191427A1
公开(公告)日：2006-08-31
申请号：US11406616
申请日：2006-04-19
Applicant: Pamela Geddes , Daniel Harrison , Jim lbarra , Claire Jalbert , Joel Neri , Michael Draper
Inventor： Pamela Geddes , Daniel Harrison , Jim lbarra , Claire Jalbert , Joel Neri , Michael Draper
IPC: B41D7/00
CPC classification number: B41M3/12 , B41P2215/56 , B41P2217/56 , B44C1/1716
Abstract: Disclosed in this specification is a decal assembly comprising a decal support, a releasable covercoat, a heat activatable layer, and an ink layer. The ink layer forms a digital image. The heat activatable layer has a high adhesion to a ceramic substrate at high temperatures and a low adhesion to the substrate at lower temperatures. Thus the adhesive properties of the decal are activated by heat. The resulting image has excellent adhesion to the substrate and resists the effects of washing.
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20.发明申请公开(公告)号：US20120245130A1
公开(公告)日：2012-09-27
申请号：US13426408
申请日：2012-03-21
Applicant: Stuart B. Levy , Michael Draper , Mark L. Nelson , Graham Jones
Inventor： Stuart B. Levy , Michael Draper , Mark L. Nelson , Graham Jones
CPC classification number: C07C237/26 , A61K31/65
Abstract: A method for modulating RNA with tetracycline compounds is described.
Abstract translation: 描述了用四环素化合物调节RNA的方法。
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