公开(公告)号：US20140274566A1

公开(公告)日：2014-09-18

申请号：US13833833

申请日：2013-03-15

Applicant: Michael Draper ,  Johnnie Paulus

Inventor： Michael Draper ,  Johnnie Paulus

IPC: A63B24/00

CPC classification number: A63B24/0062 ,  A63B21/00181 ,  A63B21/0058 ,  A63B21/0628 ,  A63B21/154 ,  A63B21/4043 ,  A63B23/03525 ,  A63B23/1209 ,  A63B24/0087 ,  A63B2024/0093

Abstract: A system and process that selectively provides lifting assistance during the concentric phase and possibly during the eccentric phase during lifting of weights for rehabilitation or training, the system being programmable to provide a variety of exercise programs dedicated to a particular user, and the system monitoring the progress of the user during the exercise to selectively respond to certain trigger conditions.

Abstract translation: 一种系统和过程，该系统和过程在提升用于康复或训练的重量期间在同心相期间以及可能在偏心阶段期间选​​择性地提供起重辅助，所述系统可编程以提供专用于特定用户的各种运动程序，并且系统监视 运动期间用户的进展以选择性地响应某些触发条件。

公开(公告)号：US20120101071A1

公开(公告)日：2012-04-26

申请号：US13338401

申请日：2011-12-28

Applicant: Michael DRAPER ,  Mark L. NELSON

Inventor： Michael DRAPER ,  Mark L. NELSON

IPC: A61K31/65 ,  A61P33/06

CPC classification number: A61K31/353 ,  A61K31/385 ,  A61K31/473 ,  A61K31/65 ,  Y02A50/411 ,  A61K2300/00

Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.

Abstract translation: 本发明提供了治疗或预防受试者中的疟疾的方法。 该方法包括向受试者施用有效量的取代的四环素化合物，使得治疗或预防疟疾。 一方面，本发明涉及药物组合物，其包含有效量的用于治疗受试者的疟疾的四环素化合物和药学上可接受的载体。 本发明的取代四环素化合物可以与一种或多种抗疟疾化合物组合使用，或可用于治疗或预防对一种或多种其它抗疟疾化合物具有抗性的疟疾。

公开(公告)号：US20110207706A1

公开(公告)日：2011-08-25

申请号：US13099993

申请日：2011-05-03

Applicant: Joel Berniac ,  Todd Bowser ,  Michael Draper ,  Stuart B. Levy ,  Mark L. Nelson

Inventor： Joel Berniac ,  Todd Bowser ,  Michael Draper ,  Stuart B. Levy ,  Mark L. Nelson

IPC: A61K31/65 ,  A61P21/00

CPC classification number: A61K31/65

Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.

Abstract translation: 描述了使用四环素化合物治疗脊髓性肌萎缩的方法。

公开(公告)号：US20080118979A1

公开(公告)日：2008-05-22

申请号：US11803854

申请日：2007-05-15

Applicant: Michael Draper ,  Mark L. Nelson

Inventor： Michael Draper ,  Mark L. Nelson

IPC: C12N5/02

CPC classification number: C12N15/635 ,  A61K31/65 ,  C12N15/85 ,  C12N2830/003

Abstract: The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to regulate gene expression in cells. Use of certain substituted tetracycline compounds, as featured in the methods of the invention, result in improved dose-response results when compared to those for e.g., tetracycline and doxycycline. Certain methods of the invention thus allow for enhanced control of the Tet repressor/operator/inducer system in regulating gene expression in cells.

Abstract translation: 本发明至少部分地涉及取代的四环素化合物用于调节与四环素操作系统可操作地连接的核酸表达的用途。 本发明涉及利用原核生物的Tet阻遏物/操纵子/诱导物系统的组分调节细胞中基因表达的调节系统中使用的化合物。 与本发明方法中所特征的某些取代的四环素化合物的使用相比，与例如四环素和多西环素相比，导致改善的剂量反应结果。 因此，本发明的某些方法允许增强Tet阻遏物/操纵子/诱导物系统在调节细胞中的基因表达方面的控制。

公开(公告)号：US20070184206A1

公开(公告)日：2007-08-09

申请号：US10550421

申请日：2004-03-18

Applicant: Michael Draper

Inventor： Michael Draper

IPC: D21F1/00

CPC classification number: D21F1/0027 ,  D21F7/08

Abstract: The present invention relates to a method of making an industrial fabric comprising the following steps: -applying a radiation-curable powder onto the surface of a fabric, melting the powder such that the powder forms a layer on the fabric surface and directing radiation at said surface layer so as to cure the constituent material of said coating layer.

Abstract translation: 本发明涉及一种制造工业织物的方法，其包括以下步骤：将可辐射固化的粉末施加到织物的表面上，使粉末熔化，使得粉末在织物表面上形成一层，并引导在所述织物表面上的辐射 表面层，以固化所述涂层的构成材料。

公开(公告)号：US20060191427A1

公开(公告)日：2006-08-31

申请号：US11406616

申请日：2006-04-19

Applicant: Pamela Geddes ,  Daniel Harrison ,  Jim lbarra ,  Claire Jalbert ,  Joel Neri ,  Michael Draper

Inventor： Pamela Geddes ,  Daniel Harrison ,  Jim lbarra ,  Claire Jalbert ,  Joel Neri ,  Michael Draper

IPC: B41D7/00

CPC classification number: B41M3/12 ,  B41P2215/56 ,  B41P2217/56 ,  B44C1/1716

Abstract: Disclosed in this specification is a decal assembly comprising a decal support, a releasable covercoat, a heat activatable layer, and an ink layer. The ink layer forms a digital image. The heat activatable layer has a high adhesion to a ceramic substrate at high temperatures and a low adhesion to the substrate at lower temperatures. Thus the adhesive properties of the decal are activated by heat. The resulting image has excellent adhesion to the substrate and resists the effects of washing.

公开(公告)号：US20050070510A1

公开(公告)日：2005-03-31

申请号：US10943571

申请日：2004-09-16

Applicant: Michael Draper ,  Mark Nelson

Inventor： Michael Draper ,  Mark Nelson

IPC: A61K45/00 ,  A61K31/65 ,  A61K31/7048 ,  A61K45/06 ,  A61P29/00 ,  A61P31/10 ,  A61P31/18 ,  A61P37/04 ,  A61P43/00

CPC classification number: A61K45/06 ,  A61K31/65 ,  A61K31/7048 ,  A61K2300/00

Abstract: Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed.

Abstract translation: 讨论了用于治疗真菌相关疾病的协同治疗的方法和组合物。

公开(公告)号：US20120245130A1

公开(公告)日：2012-09-27

申请号：US13426408

申请日：2012-03-21

Applicant: Stuart B. Levy ,  Michael Draper ,  Mark L. Nelson ,  Graham Jones

Inventor： Stuart B. Levy ,  Michael Draper ,  Mark L. Nelson ,  Graham Jones

IPC: A61K31/65 ,  A61P43/00

CPC classification number: C07C237/26 ,  A61K31/65

Abstract: A method for modulating RNA with tetracycline compounds is described.

Abstract translation: 描述了用四环素化合物调节RNA的方法。

公开(公告)号：US20090202846A1

公开(公告)日：2009-08-13

申请号：US12367173

申请日：2009-02-06

Applicant: Mohan Jayaraman ,  Michael Draper

Inventor： Mohan Jayaraman ,  Michael Draper

IPC: B32B25/04 ,  C23C4/12 ,  B32B15/04 ,  C23C4/06 ,  C23C4/10

CPC classification number: B05D1/08 ,  B05D1/06 ,  B05D1/10 ,  B05D5/10 ,  B05D2350/40 ,  Y10T428/31678

Abstract: A method is disclosed for applying thermal spray particles to a composite, wherein the method includes the steps of providing a composite that includes a thermally sensitive surface, and applying the thermal spray particles at a temperature that is high enough to cause a temperature-dependent change in the thermally sensitive surface of the composite. The temperature-dependent change improves adhesion between the thermal spay particles and the composite.

Abstract translation: 公开了一种将热喷雾颗粒施加到复合材料的方法，其中该方法包括以下步骤：提供包括热敏表面的复合材料，以及将热喷涂颗粒施加到足以引起温度依赖性变化的温度 在复合材料的热敏表面。 温度依赖性变化提高了热喷涂颗粒和复合材料之间的粘附力。

公开(公告)号：US20090131481A1

公开(公告)日：2009-05-21

申请号：US12057357

申请日：2008-03-27

Applicant: Michael N. Alekshun ,  Victoria Bartlett ,  Michael Draper ,  Lynne Garrity-Ryan ,  Raina Gay ,  Mark Grier ,  Oak K. Kim ,  Stuart B. Levy

Inventor： Michael N. Alekshun ,  Victoria Bartlett ,  Michael Draper ,  Lynne Garrity-Ryan ,  Raina Gay ,  Mark Grier ,  Oak K. Kim ,  Stuart B. Levy

IPC: A61K31/4439 ,  C12N1/36 ,  C07H21/04 ,  A61K31/4184 ,  A01N43/52 ,  A01P1/00 ,  A61P31/04 ,  A01N43/40 ,  C07D401/02 ,  C07D235/22 ,  C07D401/14

CPC classification number: A61K31/4184 ,  A61K31/437 ,  A61K31/52

Abstract: Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided.

Abstract translation: 提供了可用作降低微生物的抗性，毒力或生长的抗感染剂的取代的苯并咪唑化合物。 还提供了使用取代的苯并咪唑化合物的方法，例如降低毒力和感染性，抑制生物膜和治疗细菌感染。