公开(公告)号：US5643739A

公开(公告)日：1997-07-01

申请号：US432018

申请日：1995-05-01

申请人： Katalin Varadi ,  Hans Peter Schwarz ,  Hartmut Lang ,  Berta Moritz

发明人： Katalin Varadi ,  Hans Peter Schwarz ,  Hartmut Lang ,  Berta Moritz

IPC分类号： G01N33/86 ,  C12Q1/56 ,  C07K1/00

CPC分类号： C12Q1/56 ,  G01N2333/96444 ,  G01N2333/9645 ,  G01N2333/96461 ,  G01N2333/974 ,  G01N2405/04 ,  Y10S435/81 ,  Y10S436/808 ,  Y10S514/834

摘要： An improved assay for determining sensitivity to activated protein C in test samples has been developed to ensure rapid and accurate evaluations. This assay is based on measuring the conversion, by activated factor VIII within a test sample, of added factor X to an activated form. The activated protein C sensitivity of the test sample is determined by the relative inhibition of factor X conversion as compared to a control. A test sample that has decreased sensitivity to activated protein C will show relatively low inhibition, and vice versa.

摘要翻译： 已经开发了用于确定测试样品中对活化蛋白C的敏感性的改进测定法，以确保快速和准确的评估。 该测定法是基于测试样品中活化因子VIII的转化，将添加的因子X转化为活化形式。 与对照相比，测试样品的活化蛋白C敏感性由因子X转化的相对抑制决定。 对活化蛋白C的敏感性降低的测试样品将显示相对较低的抑制作用，反之亦然。