公开(公告)号：US20230349933A1

公开(公告)日：2023-11-02

申请号：US18140188

申请日：2023-04-27

申请人： INSTITUT DE CARDIOLOGIE DE MONTREAL

发明人： John D. RIOUX ,  Christine DES ROSIERS ,  Anik FOREST ,  Gabrielle BOUCHER ,  Romain FERRU-CLÉMENT

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2800/065 ,  G01N2800/52

摘要： Disclosed are various lipid biomarkers of inflammatory bowel disease, including biomarkers for inflammatory bowel diseases including Crohn’s disease and Ulcerative colitis. Also disclosed are various biomarkers of disease location and/or disease behavior in inflammatory bowel disease. The present disclosure also provides methods of using the biomarkers, including methods for diagnosis of inflammatory bowel disease, methods of determining predisposition to inflammatory bowel disease, methods of monitoring progression/regression of inflammatory bowel disease, and methods of assessing efficacy of compositions for treating inflammatory bowel disease.

公开(公告)号：US20230324418A1

公开(公告)日：2023-10-12

申请号：US18021211

申请日：2021-08-13

申请人： BAO FENG BIOTECH (BEIJING) CO., LTD

发明人： Xianyang CHEN ,  Wangting SONG ,  Jiarui HAN ,  Teng XUE

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N2405/08 ,  G01N2405/04 ,  G01N2405/02 ,  G01N2800/2814

摘要： This disclosure provides a use of biomarker SM(d18:1/24:1(15Z)) in the preparation of a reagent or kit for diagnosing cognitive impairment. This disclosure also provides a method for diagnosing and treating cognitive impairment by detecting the content of biomarkers SM(d18:1/24:1(15Z)) and TG(16:0/18:0/18:4(6Z,9Z,12Z,15Z)), PC(P-16:0/22:4(7Z,10Z,13Z,16Z) or PC(P-18:0/18:4(6Z,9Z,12Z,15Z)) to determine whether the patient has cognitive impairment.

公开(公告)号：US20230305027A1

公开(公告)日：2023-09-28

申请号：US18103679

申请日：2023-01-31

申请人： Genentech, Inc. ,  Hoffmann-La Roche Inc.

发明人： Qingling LI ,  Margaret NEIGHBORS ,  Carrie Melissa ROSENBERGER ,  Wendy Noel SANDOVAL ,  Gaik Wei TEW ,  Sha ZHU ,  Arindam CHAKRABARTI ,  Michele Anne GRIMBALDESTON

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N2405/04 ,  G01N2800/52 ,  G01N2800/122 ,  G01N2800/12

摘要： Provided herein are therapeutic methods for the treatment of exacerbations of inflammatory respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and asthma. In particular, the invention provides methods for patient selection, diagnosis, and treatment. Also provided herein are methods for preparing and analyzing lysophosphatidic acid (LPA) samples.

公开(公告)号：US11703508B2

公开(公告)日：2023-07-18

申请号：US16841968

申请日：2020-04-07

申请人： The Feinstein Institutes for Medical Research

发明人： Junhwan Kim

IPC分类号： G01N33/574 ,  G01N33/92 ,  A61K35/16 ,  A61K47/60

CPC分类号： G01N33/57449 ,  A61K35/16 ,  A61K47/60 ,  G01N33/92 ,  G01N2405/04

摘要： Methods are disclosed for treating ovarian tumors and ovarian and pancreatic cancers using computed and normalized relative ratios of plasma levels of phospholipids, particularly lysophosphatidylcholine, lysophosphatidylethanolamine, phosphatidylcholine, phosphatidylethanolamine and sphingomyelin.

公开(公告)号：US20180149665A1

公开(公告)日：2018-05-31

申请号：US15575115

申请日：2016-05-18

申请人： Georgetown University ,  University of Rochester

发明人： Howard J. Federoff ,  Massimo S. Fiandaca ,  Amrita K. Cheema ,  Mark E. Mapstone

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N33/6896 ,  G01N2405/04 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/60

摘要： The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

公开(公告)号：US20180149654A1

公开(公告)日：2018-05-31

申请号：US15572295

申请日：2016-05-13

申请人： ECONOUS SYSTEMS INC.

发明人： Brian De La Franier ,  Michael Thompson

IPC分类号： G01N33/574 ,  G01N33/92 ,  C07F7/12

CPC分类号： G01N33/57449 ,  C07F7/12 ,  G01N33/57442 ,  G01N33/57488 ,  G01N33/6872 ,  G01N33/92 ,  G01N2333/4703 ,  G01N2333/4712 ,  G01N2333/4727 ,  G01N2405/04 ,  G01N2610/00

摘要： The present disclosure relates to biosensors, kits and methods for detecting and/or quantifying lysophosphatidic acid (LPA) in a liquid sample such as a serum sample from a subject. The present disclosure also relates to linker compounds that are useful, for example, in the biosensors, kits and methods of the present disclosure and to methods for preparing a biosensor for detecting and/or quantifying lysophosphatidic acid (LPA) in a liquid sample.

公开(公告)号：US20180067138A1

公开(公告)日：2018-03-08

申请号：US15803252

申请日：2017-11-03

申请人： ZORA BIOSCIENCES OY

发明人： Reijo Laaksonen ,  Kim Ekroos ,  Reini Hurme ,  Riikka Katainen

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N2405/04 ,  G01N2405/06 ,  G01N2570/00 ,  G01N2800/324 ,  G01N2800/50 ,  G01N2800/52

摘要： The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided is an antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

公开(公告)号：US20170254822A1

公开(公告)日：2017-09-07

申请号：US15331880

申请日：2016-10-23

申请人： Roger A. SABBADINI

发明人： Roger A. SABBADINI

IPC分类号： G01N33/92 ,  G01N33/68

CPC分类号： G01N33/92 ,  G01N33/6896 ,  G01N2405/04 ,  G01N2800/2871

摘要： Methods and kits for detecting and diagnosing neurotrauma (e.g., traumatic brain injury, stroke, or spinal cord injury) are provided. These methods rely on the determination of lysophosphatidic acid (LPA) and/or LPA metabolite levels in patient samples following suspected injury.

公开(公告)号：US20170059594A1

公开(公告)日：2017-03-02

申请号：US15242717

申请日：2016-08-22

申请人： SYSMEX CORPORATION

发明人： Takaki YOSHIDA ,  Kurayoshi ISEKI ,  Osamu KUMANO

IPC分类号： G01N33/86

CPC分类号： G01N33/86 ,  G01N2405/04

摘要： Disclosed is a reagent for activated partial thromboplastin time measurement including an ellagic acid compound, a phospholipid, and a polyvinyl alcohol compound.

摘要翻译： 公开了用于活化的部分凝血活酶时间测定的试剂，包括鞣花酸化合物，磷脂和聚乙烯醇化合物。

公开(公告)号：US20170030935A9

公开(公告)日：2017-02-02

申请号：US14761587

申请日：2014-01-23

申请人： The Regents of the University of California

发明人： Katherine B. LOUIE ,  Benjamin P. BOWEN ,  Trent R. NORTHEN

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N33/574 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2458/15 ,  G01N2560/00 ,  G01N2800/7028

摘要： Disclosed herein are methods for identifying one or more diseased cells in a subject, methods for cancer diagnosis, methods for determining cancer progression in a subject and methods for assessing health status in a subject.

摘要翻译： 本文公开了用于鉴定受试者中的一种或多种患病细胞的方法，用于癌症诊断的方法，用于确定受试者中癌症进展的方法和用于评估受试者的健康状况的方法。