公开(公告)号：US10023626B2

公开(公告)日：2018-07-17

申请号：US15025994

申请日：2014-09-30

Applicant: ModernaTX, Inc.

Inventor： Joseph Beene Bolen ,  Joshua P. Frederick

IPC: C07K14/705 ,  A61K48/00 ,  A61K31/7115

CPC classification number: C07K14/70578 ,  A61K31/7115 ,  A61K48/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.

公开(公告)号：US11708396B2

公开(公告)日：2023-07-25

申请号：US17162061

申请日：2021-01-29

Applicant: ModernaTX, Inc.

Inventor： Stephen G. Hoge ,  Tirtha Chakraborty ,  Joshua P. Frederick ,  Matthias John ,  Antonin De Fougerolles

IPC: A61K48/00 ,  C07K14/47 ,  C12N15/85 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/711 ,  A61K38/00

CPC classification number: C07K14/47 ,  A61K31/711 ,  A61K31/7105 ,  A61K48/0058 ,  C12N15/113 ,  C12N15/85 ,  A61K38/00 ,  C12N2310/141

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

公开(公告)号：US11344504B1

公开(公告)日：2022-05-31

申请号：US17352904

申请日：2021-06-21

Applicant: ModernaTX, Inc.

Inventor： Joshua P. Frederick ,  Ailin Bai ,  Vladimir Presnyak ,  Stephen G. Hoge ,  Kerry Benenato ,  Iain McFadyen ,  Ellalahewage Sathyajith Kumarasinghe ,  Susannah Hewitt

IPC: A61K38/20 ,  A61K9/51 ,  A61K48/00 ,  A61K38/17 ,  A61K9/00 ,  A61K39/39 ,  A61K45/06 ,  A61K9/127 ,  C07K14/54 ,  C07K14/545 ,  C07K14/705 ,  A61K31/7088 ,  A61K31/7115 ,  A61P35/00 ,  A61K39/395 ,  A61K39/00 ,  B82Y5/00 ,  C12N15/88

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).

公开(公告)号：US10973917B2

公开(公告)日：2021-04-13

申请号：US16457300

申请日：2019-06-28

Applicant: ModernaTX, Inc.

Inventor： Joshua P. Frederick ,  Susannah Hewitt ,  Ailin Bai ,  Stephen G. Hoge ,  Vladimir Presnyak ,  Iain McFadyen ,  Kerry Benenato ,  Ellalahewage Sathyajith Kumarasinghe

IPC: A61K48/00 ,  A61K39/395 ,  C07K14/54 ,  C07K14/705 ,  C07K16/28 ,  A61K39/39 ,  A61K45/06 ,  A61K31/713 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure relates to the use of nucleic acid (e.g., mRNA) combination therapies for the treatment of cancer. The disclosure provides compositions, and methods for their preparation, manufacture, and therapeutic use, wherein those compositions comprise at least two polynucleotides (e.g., mRNAs) in combination wherein the at least two polynucleotides are selected from the group consisting of (i) a polynucleotide encoding an immune response primer (e.g., IL23), (ii) a polynucleotide encoding an immune response co-stimulatory signal (e.g., OX40L), (iii) a polynucleotide encoding a checkpoint inhibitor (e.g., an anti CTLA-4 antibody), and, (iv) a combination thereof. The therapeutic methods disclosed herein comprise, e.g., the administration of a combination therapy disclosed herein for the treatment of cancer, e.g., by reducing the size of a tumor or inhibiting the growth of a tumor, in a subject in need thereof. In some aspects, the combination therapies disclosed herein disclosed are administered intratumorally.

公开(公告)号：US20190016781A1

公开(公告)日：2019-01-17

申请号：US16009717

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Joseph Beene Bolen ,  Joshua P. Frederick

IPC: C07K14/705 ,  A61K31/7115 ,  A61K48/00

CPC classification number: C07K14/70578 ,  A61K31/7115 ,  A61K48/00

Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules encoding at least one polypeptide of interest to modulate the immune response.

公开(公告)号：US10143723B2

公开(公告)日：2018-12-04

申请号：US15996140

申请日：2018-06-01

Applicant: ModernaTX, Inc.

Inventor： Joshua P. Frederick ,  Ailin Bai

IPC: A61K48/00 ,  A61K38/17 ,  A61P35/00 ,  A61K45/06

Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules comprising an mRNA encoding an OX40L polypeptide. Also provided is a method for activating T cells or increasing the number of NK cells in a subject in need thereof.