公开(公告)号：US07231249B2

公开(公告)日：2007-06-12

申请号：US10625526

申请日：2003-07-24

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.

摘要翻译： 提供方法，装置和系统以刺激心脏中的多个部位。 控制器感测与心脏窦性心律相关的电活动。 信号发生器被配置为产生用于刺激心脏的电信号。 基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。 分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

公开(公告)号：US07203537B2

公开(公告)日：2007-04-10

申请号：US10754887

申请日：2004-01-10

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/37

CPC分类号： A61N1/3622 ,  A61B2017/00044 ,  A61F7/12 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0095 ,  A61F2007/126 ,  A61N1/3624

摘要： Systems and methods to inhibit the conduction of certain spurious electrical impulses in the heart. Inhibition of spurious electrical impulses in the heart is accomplished by cooling one or more targeted portions of the heart. Optionally, inhibition of spurious electrical impulses may be accomplished by cooling of cardiac tissue in combination with pacing of the heart.

摘要翻译： 抑制心脏中某些杂散电脉冲传导的系统和方法。 通过冷却心脏的一个或多个目标部分来实现对心脏中的杂散电脉冲的抑制。 任选地，可以通过与心脏的起搏相结合来冷却心脏组织来实现寄生电脉冲的抑制。

公开(公告)号：US06295470B1

公开(公告)日：2001-09-25

申请号：US09231570

申请日：1999-01-14

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1362

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/36514 ,  A61N1/3712 ,  A61N1/3962

摘要： Protocols for antitachycardial pacing including biphasic stimulation administered at, or just above, the diastolic depolarization threshold potential; biphasic or conventional stimulation initiated at, or just above, the diastolic depolarization threshold potential, reduced, upon capture, to below threshold; and biphasic or conventional stimulation administered at a level set just below the diastolic depolarization threshold potential. These protocols result in reliable cardiac capture with a lower stimulation level, thereby causing less damage to the heart, extending battery life, causing less pain to the patient and having greater therapeutic effectiveness. In those protocols using biphasic cardiac pacing, a first and second stimulation phase is administered. The first stimulation phase has a predefined polarity, amplitude and duration. The second stimulation phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with the increase in contractility.

摘要翻译： 用于抗心动过速起搏的方案，包括在舒张期去极化阈值电位施用或恰好高于舒张去极化阈值电位的双相刺激; 在舒张去极化阈值电位或之前开始的双相或常规刺激，在捕获时降低到阈值以下; 以及在恰好低于舒张期去极化阈值电位的水平下施用的双相或常规刺激。 这些协议导致可靠的心脏捕获，具有较低的刺激水平，从而对心脏造成较小的损伤，延长电池寿命，对患者造成更少的疼痛并具有更大的治疗效果。 在使用双相心脏起搏的那些方案中，施用第一和第二刺激阶段。 第一刺激阶段具有预定义的极性，幅度和持续时间。 第二刺激阶段也具有预定义的极性，幅度和持续时间。 顺序应用两个阶段。 与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。 以这种方式，通过心肌的脉冲传导随着收缩性的增加而提高。

公开(公告)号：US6141586A

公开(公告)日：2000-10-31

申请号：US084571

申请日：1998-05-26

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/36592 ,  A61N1/3622 ,  A61N1/368 ,  A61N1/3712 ,  A61N1/36514

摘要： Method and apparatus for cyclic ventricular pacing starting at a rate just above the intrinsic atrial firing rate (overdrive pacing), followed by relaxation to a rate just below the intrinsic atrial firing rate (ventricular escape). The method and apparatus can be applied to one or both ventricles, and can utilize one or more electrodes per ventricle. The electrode(s) can be applied to inner or outer ventricular surfaces. Relaxation protocols as a function of time can be linear, curvilinear to include exponential, or mixtures thereof. Furthermore, relaxation protocols can include one or more periods of time during which the pacing rate is held constant. Typically, the average ventricular pacing rate using this invention will be slightly greater than the intrinsic atrial firing rate, though alternate embodiments that encompass average ventricular pacing rates that are equal to or slightly less than the intrinsic atrial firing rate are also envisioned. Application of this method and apparatus to a heart in need thereof will produce a heart with an optimally minimized energy output requirement.

摘要翻译： 循环心室起搏的方法和装置，起始速度高于固有心房发射率（超速起搏），然后放松到刚好低于固有心房放电速率（心室逸出）的速率。 该方法和装置可以应用于一个或两个心室，并且可以利用每个心室的一个或多个电极。 电极可以应用于内心室或外心室表面。 作为时间的函数的松弛方案可以是线性的，曲线的包括指数，或其混合物。 此外，放松协议可以包括起搏速率保持恒定的一个或多个时间段。 通常，使用本发明的平均心室起搏速率将稍微大于固有心房放电速率，尽管也可以设想包括等于或略小于固有心房发射率的平均心室起搏速率的替代实施例。 将该方法和装置应用于有需要的心脏将产生具有最佳最小能量输出要求的心脏。

公开(公告)号：US5871506A

公开(公告)日：1999-02-16

申请号：US699552

申请日：1996-08-19

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37

CPC分类号： A61N1/3628 ,  A61N1/3627 ,  A61N1/3712 ,  A61N1/36514

摘要： Augmentation of electrical conduction and contractility by biphasic cardiac pacing. A first stimulation phase is administered to the muscle tissue. This first stimulation phase has a predefined polarity, amplitude and duration. A second stimulation phase is then administered to the muscle tissue. This second phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with an increase in contractility. The technique can also be applied to large muscle tissue stimulation other than cardiac muscle.

摘要翻译： 通过双相心脏起搏增强电传导和收缩。 向肌肉组织施用第一刺激阶段。 该第一刺激阶段具有预定义的极性，幅度和持续时间。 然后将第二刺激期施用于肌肉组织。 该第二阶段也具有预定义的极性，幅度和持续时间。 顺序应用两个阶段。 与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。 以这种方式，通过心肌的脉冲传导随着收缩性的增加而提高。 该技术也可应用于心肌以外的大肌肉组织刺激。

公开(公告)号：US5020544A

公开(公告)日：1991-06-04

申请号：US430050

申请日：1989-11-01

申请人： Roger W. Dahl ,  Ronald W. Heil, Jr. ,  Graydon E. Beatty ,  Morton M. Mower

发明人： Roger W. Dahl ,  Ronald W. Heil, Jr. ,  Graydon E. Beatty ,  Morton M. Mower

IPC分类号： A61N1/05

CPC分类号： A61N1/0587

摘要： An implantable cardiac electrode for use in defibrillation. The electrode comprises a plurality of layers of porous conductive screens and backed by an insulation layer. When implanted on or about the heart surface, body fluids can flow through the screens thus increasing the effective surface area of contact. Each individual layer of mesh can be microscopically textured to create indentations on the layer for further increasing the surface area of each screen, and thus, the surface area of body fluid contact. Also disclosed is an electrode without an insulative backing facing away from the heart.

摘要翻译： 用于除颤的植入式心脏电极。 电极包括多层多孔导电屏，并由绝缘层支撑。 当植入心脏表面或其周围时，体液可以流过筛网，从而增加接触的有效表面积。 每个单独的网格层可以被显微纹理化以在该层上产生凹痕，以进一步增加每个筛网的表面积，并因此增加体液接触的表面积。 还公开了一种没有背离心脏的绝缘背衬的电极。

公开(公告)号：US3952750A

公开(公告)日：1976-04-27

申请号：US464180

申请日：1974-04-25

申请人： Mieczyslaw Mirowski ,  Morton M. Mower ,  Alois A. Langer

发明人： Mieczyslaw Mirowski ,  Morton M. Mower ,  Alois A. Langer

IPC分类号： A61N1/362 ,  A61N1/372 ,  A61N1/378 ,  A61N1/39 ,  A61N1/36

CPC分类号： A61N1/3787 ,  A61N1/362 ,  A61N1/372 ,  A61N1/37211 ,  A61N1/3925

摘要： An externally controlled implantable electronic device for delivering a cardioverting pulse of energy to the atrium of an ailing heart. In one embodiment, the device is particularly suited for use when the patient visits the office of his physician, and contemplates the transmission of both information and powering energy through the skin of the patient. In another embodiment, the device can be readily operated at home, by the patient, and without the intervention of the physician. Here, the source of energy is permanently implanted.

摘要翻译： 外部控制的可植入电子装置，用于将心律转移的能量脉冲递送到有心脏的心房。 在一个实施例中，该装置特别适合于当患者访问他的医生的办公室时使用，并且考虑信息的传递和通过患者的皮肤供电能量。 在另一个实施例中，该装置可以容易地在家中由患者操作，而不需要医师的介入。 在这里，永久植入能源。

公开(公告)号：US09566444B2

公开(公告)日：2017-02-14

申请号：US14272730

申请日：2014-05-08

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61N1/362

CPC分类号： A61N1/368 ,  A61N1/3627 ,  A61N1/3684

摘要： Methods, apparatus, and systems are provided to stimulate multiple sites in a heart. A controller senses electrical activity associated with sinus rhythm of the heart. A signal generator is configured to generate an electrical signal for stimulating the heart. Based on the electrical signal, a distributor circuit then distributes the stimulating signals, such as pacing pulses, to a heart. The distributor circuit may vary the delay time between stimulating signals, inhibit a stimulating signal, trigger application of a stimulating signal, or vary the characteristics, such as the pulse width and amplitude, of a stimulating signal.

摘要翻译： 提供方法，装置和系统以刺激心脏中的多个部位。 控制器感测与心脏窦性心律相关的电活动。 信号发生器被配置为产生用于刺激心脏的电信号。 基于电信号，分配器电路然后将刺激信号（例如起搏脉冲）分配到心脏。 分配器电路可以改变刺激信号之间的延迟时间，抑制刺激信号，触发施加刺激信号，或改变刺激信号的特性，例如脉冲宽度和幅度。

公开(公告)号：USRE39897E1

公开(公告)日：2007-10-23

申请号：US10214474

申请日：2002-08-08

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/368 ,  A61N1/3684

摘要： A method of treating hemodynamic disfunction by simultaneously pacing both ventricles of a heart. At least one ECG amplifier is arranged to separately detect contraction of each ventricle and a stimulator is then activated for issuing stimulating pulses to both ventricles in a manner to assure simultaneous contraction of both ventricles, thereby to assure hemodynamic efficiency. A first ventricle is stimulated simultaneously with contraction of a second ventricle when the first fails to properly contract. Further, both ventricles are stimulated after lapse of a predetermined A-V escape interval. One of a pair of electrodes, connected in series, in placed through the superior vena cava into the right ventricle and a second is placed in the coronary sinus about the left ventricle. Each electrode performs both pacing and sensing functions. The pacer is particularly suitable for treating bundle branch blocks or slow conduction in a portion of the ventricles.

摘要翻译： 通过同时起搏心脏的两个心室来治疗血液动力学障碍的方法。 至少一个ECG放大器被设置为分别检测每个心室的收缩，然后激活刺激器以便以两种心室的刺激脉冲发出刺激脉冲，以确保两个脑室同时收缩，从而确保血液动力学效率。 当第一个心室不能正常收缩时，第一个心室与第二个心室的收缩同时受到刺激。 此外，在经过预定的A-V逃逸间隔之后刺激两个心室。 串联连接的一对电极之一，通过上腔静脉置入右心室，另一个电极放置在围绕左心室的冠状窦中。 每个电极执行起搏和感应功能。 该起搏器特别适用于治疗束支传导阻滞或在一部分心室中缓慢传导。

公开(公告)号：USRE38119E1

公开(公告)日：2003-05-20

申请号：US08547691

申请日：1995-10-19

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N100

CPC分类号： A61N1/3627 ,  A61N1/368 ,  A61N1/3684

摘要： A method of treating hemodynamic disfunction by simultaneously pacing both ventricles of a heart. At least one ECG amplifier is arranged to separately detect contraction of each ventricle and a stimulator is then activated for issuing stimulating pulses to both ventricles in a manner to assure simultaneous contraction of both ventricles, thereby to assure hemodynamic efficiency. A first ventricle is stimulated simultaneously with contraction of a second ventricle when the first fails to properly contract. Further, both ventricles are stimulated after lapse of a predetermined A-V escape interval. One of a pair of electrodes, connected in series, is placed through the superior vena cava into the right ventricle and a second is placed in the coronary sinus about the left ventricle. Each electrode performs both pacing and sensing functions. The pacer is particularly suitable for treating bundle branch blocks or slow conduction in a portion of the ventricles.