公开(公告)号：US12252482B2

公开(公告)日：2025-03-18

申请号：US18826887

申请日：2024-09-06

Applicant: Novartis AG

Inventor： Simone Bonazzi ,  Jennifer Stroka Cobb ,  Natalie Alysia Dales ,  Matthew James Hesse ,  Rama Jain ,  John Ryan Kerrigan ,  Hasnain Ahmed Malik ,  James R Manning ,  Pamela Yf Ting

IPC: C07D403/14 ,  A61P7/00 ,  C07D405/14 ,  C07D417/14

Abstract: The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.

公开(公告)号：US11453677B2

公开(公告)日：2022-09-27

申请号：US16933000

申请日：2020-07-20

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.