公开(公告)号：US11597733B2

公开(公告)日：2023-03-07

申请号：US17076126

申请日：2020-10-21

Applicant: Novartis AG

Inventor： Nicole Alice Blaquiere ,  Richard Yichong Huang ,  Thomas Martin Kirrane, Jr. ,  Andreas Kordikowski ,  Anne-Catherine Mata ,  Christopher Ronald Sarko ,  Benjamin Robert Taft ,  Grace Lamprecht Waldron ,  Fumiaki Yokokawa ,  Tingying Zhu

IPC: C07D513/04 ,  C07D519/00 ,  A61K31/4545 ,  A61K31/433 ,  A61K31/496 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/5386 ,  A61K31/438 ,  A61K31/5355 ,  A61K31/499 ,  A61K31/454

Abstract: The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.

公开(公告)号：US11098051B2

公开(公告)日：2021-08-24

申请号：US16328616

申请日：2017-08-25

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  Vanessa Marx ,  Daniel Poon ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Aregahegn Yifru ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D498/14 ,  A61P31/16 ,  A61K31/16 ,  A61K31/5025 ,  A61K31/53 ,  A61K31/5365 ,  A61K31/5383 ,  A61K31/551

Abstract: The invention provides compounds of Formula (I): as further described herein, as well as pharmaceutical compositions comprising such compounds, and methods to use the compounds and pharmaceutical compositions for treatment of certain viral disorders, including influenza.

公开(公告)号：US10858366B2

公开(公告)日：2020-12-08

申请号：US16083089

申请日：2017-03-07

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.

公开(公告)号：US11453677B2

公开(公告)日：2022-09-27

申请号：US16933000

申请日：2020-07-20

Applicant: Novartis AG

Inventor： Rama Jain ,  Dennis Christofer Koester ,  James R. Manning ,  James Clifford Sutton ,  Benjamin Robert Taft ,  Lifeng Wan ,  Qian Zhao

IPC: C07D487/14 ,  C07D471/14 ,  C07D491/22 ,  C07D498/14 ,  A61P31/16 ,  C07D513/14

Abstract: The present invention provides a compound of Formula (I) including pharmaceutically acceptable salts thereof: (I) and therapeutic uses of these compounds. The invention further provides pharmaceutical compositions comprising these compounds, compositions comprising these compounds with a therapeutic co-agent, and methods of using the compounds and compositions to treat viral infections.

公开(公告)号：US20210115065A1

公开(公告)日：2021-04-22

申请号：US17076126

申请日：2020-10-21

Applicant: Novartis AG

Inventor： Nicole Alice Blaquiere ,  Richard Yichong Huang ,  Thomas Martin Kirrane, JR. ,  Andreas Kordikowski ,  Anne-Catherine Mata ,  Christopher Ronald Sarko ,  Benjamin Robert Taft ,  Grace Lamprecht Waldron ,  Fumiaki Yokokawa ,  Tingying Zhu

IPC: C07D513/04 ,  C07D519/00 ,  A61K31/4545 ,  A61K31/433 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/5386 ,  A61K31/438 ,  A61K31/5355 ,  A61K31/499 ,  A61K45/06

Abstract: The present invention provides a compound of formula (Ia) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, solid forms, combinations of pharmacologically active agents, pharmaceutical compositions and methods of using such compounds and solid forms thereof to treat or prevent parasitic diseases, for example malaria.