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11.发明授权公开(公告)号：US10966625B2
公开(公告)日：2021-04-06
申请号：US15838383
申请日：2017-12-12
Applicant: NeuroPace, Inc.
Inventor： Sharanya Arcot Desai , Thomas K. Tcheng , Stephen T. Archer
Abstract: A sensor of an implantable medical device senses electrical activity of the brain. A data analyzer of the device monitors an electrographic signal corresponding to the electrical activity of the sensed brain signal, and processes the brain signal to obtain a measure of phase-amplitude coupling. For a selected portion of the electrographic signal, the data analyzer detects first features and second features of the electrographic signal. The first features represent oscillations in a low frequency range, while the second features represent oscillations in a frequency range higher than the low frequency range. For example, the low frequency range may correspond to theta frequency and the higher frequency range may correspond to gamma frequency. The data analyzer determines a measure of phase-amplitude coupling between oscillations in the low frequency range and oscillations in the higher frequency range based on occurrences of second features which coincide with first features.
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公开(公告)号：US10193217B2
公开(公告)日：2019-01-29
申请号：US15994993
申请日：2018-05-31
Applicant: NeuroPace, Inc.
Inventor： Dean Andersen , Stephen T. Archer , John Dunagan Pearson
Abstract: A flexible antenna is associated with an active implantable medical device to facilitate communication between the implantable medical device and an external component in the outside world via, for example, long range or far field telemetry. The flexibility of the antenna allows it to conform to the shape of the location at which it is situated, such as on the cranial bone of a patient for an antenna associated with a cranially implanted medical device. The conformability of the antenna helps to maintain the antenna in the desired shape and to maintain it in the desired location relative to implantable medical device and the patient and improves patient comfort.
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13.发明授权公开(公告)号：US09604061B2
公开(公告)日：2017-03-28
申请号：US15261822
申请日：2016-09-09
Applicant: NeuroPace, Inc.
Inventor： Stephen T. Archer
IPC: A61N1/36
CPC classification number: A61N1/36157 , A61N1/36125
Abstract: A current management system for use in the stimulation output stage of a neurostimulation system can be programmed to steer different amounts of current through different stimulation electrodes to vary how strongly the tissue adjacent each electrode is stimulated during a particular programmed stimulation episode. An stimulation electrode drive circuit associated with each electrode that is available for stimulation allows independent control of the flow of current through that electrode. A reference electrode is provided in the circuit to source or sink current as necessary to balance the currents going into and out of the patient, so that no stimulation electrode is required to serve that purpose. More specifically, by configuring the circuit to maintain a constant potential at the reference electrode (e.g., a potential that is approximately half way between a top and bottom voltage rail), the reference electrode will source or sink currents as necessary to cause the net current flow into the patient to be equal to the net current flowing out of the patient, thus satisfying Kirchhoff's current law.
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14.发明授权公开(公告)号：US09468765B2
公开(公告)日：2016-10-18
申请号：US14843785
申请日：2015-09-02
Applicant: NeuroPace, Inc.
Inventor： Stephen T. Archer
IPC: A61N1/36
CPC classification number: A61N1/36157 , A61N1/36125
Abstract: A current management system for use in the stimulation output stage of a neurostimulation system can be programmed to steer different amounts of current through different stimulation electrodes to vary how strongly the tissue adjacent each electrode is stimulated during a particular programmed stimulation episode. An stimulation electrode drive circuit associated with each electrode that is available for stimulation allows independent control of the flow of current through that electrode. A reference electrode is provided in the circuit to source or sink current as necessary to balance the currents going into and out of the patient, so that no stimulation electrode is required to serve that purpose. More specifically, by configuring the circuit to maintain a constant potential at the reference electrode (e.g., a potential that is approximately half way between a top and bottom voltage rail), the reference electrode will source or sink currents as necessary to cause the net current flow into the patient to be equal to the net current flowing out of the patient, thus satisfying Kirchhoff's current law.
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