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公开(公告)号：US20220323019A1
公开(公告)日：2022-10-13
申请号：US17709159
申请日：2022-03-30
申请人： NeuroPace, Inc.
发明人： Sharanya Arcot Desai , Tara L. Crowder , Thomas K. Tcheng , Martha J. Morrell , Lise Johnson Dyhr
摘要： A clinical response estimate (CRE) biomarker of a patient having an implanted neurostimulation system is monitored. To this end, an input dataset is derived from a subject-patient dataset that includes various different data types and different features of the patient. The data types are based on electrical activity the patient's brain sensed and stored by the implanted neurostimulation system. The input dataset is a subset of the larger subject-patient dataset, and the specific data types and patient features included in that subset are derived based on a plurality of key inputs of the subject-patient dataset. Once the input dataset is derived, it is processed by a clinical response estimator having machine-learned models. First and second machine-learned models of the clinical response estimator are applied to the input dataset to provide model inputs to an ensemble machine-learned model to determine the CRE biomarker.
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公开(公告)号：US11026617B2
公开(公告)日：2021-06-08
申请号：US16442424
申请日：2019-06-14
申请人： NeuroPace, Inc.
发明人： Thomas K. Tcheng
IPC分类号： A61B5/291 , A61N1/36 , A61B5/00 , A61B5/026 , A61B5/1455 , A61B5/16 , A61N1/05 , A61B5/316 , A61B5/0205 , A61N1/02
摘要： A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
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公开(公告)号：US20190298211A1
公开(公告)日：2019-10-03
申请号：US16442424
申请日：2019-06-14
申请人： NeuroPace, Inc.
发明人： Thomas K. Tcheng
IPC分类号： A61B5/0478 , A61N1/36 , A61B5/00 , A61N1/02 , A61B5/026 , A61B5/1455 , A61B5/16 , A61B5/0205 , A61B5/04 , A61N1/05
摘要： A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography). Acquisition of measurements and the lead components and other components for accomplishing a measurement in each modality are also described as are various applications for the multimodal brain sensing lead.
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公开(公告)号：US10321866B2
公开(公告)日：2019-06-18
申请号：US14484605
申请日：2014-09-12
申请人： NeuroPace, Inc.
发明人： Benjamin D. Pless , Stephen T. Archer , Craig M. Baysinger , Barbara Gibb , Suresh Gurunathan , Bruce Kirkpatrick , Thomas K. Tcheng
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0476 , A61B5/0478
摘要： Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
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公开(公告)号：US09314182B2
公开(公告)日：2016-04-19
申请号：US13679925
申请日：2012-11-16
申请人： NeuroPace, Inc.
IPC分类号： A61B5/04 , A61B5/0476 , A61B5/048 , A61B5/0484 , A61B5/00 , A61B5/16 , A61B5/07
CPC分类号： A61B5/0476 , A61B5/0031 , A61B5/048 , A61B5/0484 , A61B5/076 , A61B5/16 , A61B5/4094 , A61B5/7257
摘要： A system and method for detecting and predicting neurological events with an implantable device uses a relatively low-power central processing unit in connection with signal processing circuitry to identify features (including half waves) and calculate window-based characteristics (including line lengths and areas under the curve of the waveform) in one or more electrographic signals received from a patient's brain. The features and window-based characteristics are employed within the framework of a programmable finite state machine to identify patterns and sequences in and across the electrographic signals, facilitating early and reliable detection and prediction of complex spatiotemporal neurological events in real time, and enabling responsive action by the implantable device.
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公开(公告)号：US09186508B2
公开(公告)日：2015-11-17
申请号：US14059090
申请日：2013-10-21
申请人： NeuroPace, Inc.
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36135
摘要： An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of supplying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.
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公开(公告)号：US20230017756A1
公开(公告)日：2023-01-19
申请号：US17948947
申请日：2022-09-20
申请人： NeuroPace, Inc.
摘要： A deep learning model and dimensionality reduction are applied to each of a plurality of records of physiological information to derive a plurality of feature vectors. A similarities algorithm is applied to the plurality of feature vectors to form a plurality of clusters, each including a set of feature vectors. An output comprising information that enables a display of one or more of the plurality of clusters is provided, and a mechanism for selecting at least one feature vector within a selected cluster of the plurality of clusters is enabled. Upon selection of a feature vector, an output comprising information that enables a display of the record of physiological information corresponding to the selected feature vector is provided, and a mechanism for assigning a label to the displayed record is enabled. The assigned label is then automatically assigned to the records corresponding to the remaining feature vectors in the selected cluster.
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公开(公告)号：US20220313159A1
公开(公告)日：2022-10-06
申请号：US17709195
申请日：2022-03-30
申请人： NeuroPace, Inc.
发明人： Sharanya Arcot Desai , Tara L. Crowder , Thomas K. Tcheng , Martha J. Morrell , Lise Johnson Dyhr
摘要： An input dataset is processed to obtain a pre-event window of model inputs and a post-event window of model inputs. The input dataset is a subset of a larger subject-patient dataset that includes different data types and features of the patient. The data types are based on electrical activity of the patient's brain that is sensed and stored by an implanted neurostimulation system. A clinical response estimator (CRE) model is applied to the pre-event window of model inputs to derive pre-event CRE biomarkers. The CRE model is also applied to the post-event window of model inputs to derive post-event CRE biomarkers. The pre-event CRE biomarkers and post-event CRE biomarkers are displayed as a function of time together with the occurrence of the event of interest.
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9.发明申请公开(公告)号：US20200272857A1
公开(公告)日：2020-08-27
申请号：US16796692
申请日：2020-02-20
申请人： NeuroPace, Inc.
摘要： A deep learning model and dimensionality reduction are applied to each of a plurality of records of physiological information to derive a plurality of feature vectors. A similarities algorithm is applied to the plurality of feature vectors to form a plurality of clusters, each including a set of feature vectors. An output comprising information that enables a display of one or more of the plurality of clusters is provided, and a mechanism for selecting at least one feature vector within a selected cluster of the plurality of clusters is enabled. Upon selection of a feature vector, an output comprising information that enables a display of the record of physiological information corresponding to the selected feature vector is provided, and a mechanism for assigning a label to the displayed record is enabled. The assigned label is then automatically assigned to the records corresponding to the remaining feature vectors in the selected cluster.
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公开(公告)号：US10729907B2
公开(公告)日：2020-08-04
申请号：US15849492
申请日：2017-12-20
申请人： NeuroPace, Inc.
摘要： Information relevant to making clinical decisions for a patient is identified based on electrical activity records of the patient's brain and electrical activity records of other patients' brains. A deep learning algorithm is applied to an electrical activity record of the patient, i.e., an input record, and to a set of electrical activity records of other patients, i.e., a set of search records, to obtain an input feature vector of the patient and a set of search feature vectors, each including features extracted by the deep learning algorithm. A similarities algorithm is applied to the input feature vector and the set of search feature vectors to identify a subset of search records most like the input record. Clinical information associated with one or more search records in the identified subset of search records is extracted from a database and used to make decisions regarding the patient's neuromodulation therapies.
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