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公开(公告)号：US10071973B2
公开(公告)日：2018-09-11
申请号：US15620373
申请日：2017-06-12
Applicant: Novartis AG
Inventor： Jiping Fu , Siyi Jiang , Andreas Kordikowski , Zachary Kevin Sweeney
IPC: C07D261/08 , A61K31/7048 , A61K38/14 , A61K38/12 , A61K31/431 , A61K31/65 , A61K31/7036 , A61K31/496 , A61K31/5383 , A61K31/42 , A61K31/43 , A61K31/546
CPC classification number: C07D261/08 , A61K31/42 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/5383 , A61K31/546 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K38/12 , A61K38/14 , C07B2200/13
Abstract: This invention pertains to a crystalline compound of Formula (A) as described herein and compositions containing this crystalline compound, as well as methods of using the compound or pharmaceutical compositions comprising it to treat bacterial infections. The compound and compositions are especially useful to treat Gram negative bacterial infections, including multi-drug resistant strains.
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公开(公告)号：US09566312B2
公开(公告)日：2017-02-14
申请号：US14717872
申请日：2015-05-20
Applicant: Novartis AG
Inventor： Jiping Fu , Subramanian Karur , Xiaolin Li , Peichao Lu , Wosenu Mergo , Alexey Rivkin , Zachary Kevin Sweeney , Meiliana Tjandra , Andrew Weiss , Aregahegn Yifru
Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
Abstract translation: 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。
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