公开(公告)号：US10301312B2

公开(公告)日：2019-05-28

申请号：US15965172

申请日：2018-04-27

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Subramanian Karur ,  Peichao Lu ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: C07D471/14 ,  C07D405/12 ,  A61P31/12 ,  C07D491/16 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4985 ,  C07D471/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US09566312B2

公开(公告)日：2017-02-14

申请号：US14717872

申请日：2015-05-20

Applicant: Novartis AG

Inventor： Jiping Fu ,  Subramanian Karur ,  Xiaolin Li ,  Peichao Lu ,  Wosenu Mergo ,  Alexey Rivkin ,  Zachary Kevin Sweeney ,  Meiliana Tjandra ,  Andrew Weiss ,  Aregahegn Yifru

IPC: A61K38/12 ,  A61K38/13 ,  C07K7/64 ,  A61K45/06

CPC classification number: A61K38/13 ,  A61K38/12 ,  A61K45/06 ,  C07K7/64 ,  C07K7/645 ,  A61K2300/00

Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.

Abstract translation: 本发明提供式I化合物; 或其药学上可接受的盐，其中本文定义的变量R1，R2，R3，R4，R5和AB是非免疫抑制性亲环蛋白结合的mPTP阻断剂，因此可用于预防或治疗疾病或 疾病如HCV感染，中风，多发性硬化，HBV感染，HPV感染，哮喘，癌症，肌营养不良，败血症，缺血/再灌注损伤和心力衰竭。

公开(公告)号：US09815804B2

公开(公告)日：2017-11-14

申请号：US15375560

申请日：2016-12-12

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume Lapointe ,  Ann Marie Madera ,  Zachary Kevin Sweeney

IPC: C07D261/08 ,  A61K31/42 ,  A61K45/06 ,  C07D413/12 ,  A61K31/422 ,  C07D413/06

CPC classification number: C07D261/08 ,  A61K31/42 ,  A61K31/422 ,  A61K45/06 ,  C07D413/06 ,  C07D413/12 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481 ,  A61K2300/00

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.

公开(公告)号：US10975078B2

公开(公告)日：2021-04-13

申请号：US16808985

申请日：2020-03-04

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Subramanian Karur ,  Peichao Lu ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: C07D471/14 ,  C07D405/12 ,  A61P31/12 ,  C07D491/16 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4985 ,  C07D471/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US10029994B2

公开(公告)日：2018-07-24

申请号：US15728351

申请日：2017-10-09

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume Lapointe ,  Ann Marie Madera ,  Zachary Kevin Sweeney

IPC: C07D261/08 ,  C07D413/12 ,  C07D413/06 ,  A61K31/422 ,  A61K45/06 ,  A61K31/42

Abstract: This invention pertains generally to compounds of Formula I as described herein and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention provides methods and compositions comprising these compounds for treating infections caused by Gram-negative bacteria.

公开(公告)号：US09718792B2

公开(公告)日：2017-08-01

申请号：US15454187

申请日：2017-03-09

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Subramanian Karur ,  Guillaume LaPointe ,  Patrick Lee ,  Zachary Kevin Sweeney

IPC: C07D417/10 ,  C07D261/04 ,  A61K31/42 ,  C07D413/04 ,  A61K31/4439 ,  C07D413/10 ,  A61K31/5377 ,  A61K31/427 ,  A61K31/422 ,  A61K45/06

CPC classification number: C07D261/04 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D413/10 ,  C07D417/10

Abstract: This invention pertains generally to compounds of Formula I and compositions containing such compounds, as well as methods of using such compounds to treat bacterial infections. In certain aspects, the invention pertains to methods and compositions for treating infections caused by Gram-negative bacteria.