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公开(公告)号：US07264810B2
公开(公告)日：2007-09-04
申请号：US10050902
申请日：2002-01-18
申请人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
发明人： Wolfgang A. Renner , Martin Bachmann , Alain Tissot , Patrick Maurer , Franziska Lechner , Peter Sebbel , Christine Piossek
IPC分类号： A61K39/385 , A61K9/00 , A61K39/00 , A61K47/30
CPC分类号： A61K39/12 , A61K38/00 , A61K39/0005 , A61K39/0007 , A61K39/0008 , A61K39/001 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/6901 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/627 , C07K14/005 , C07K14/523 , C07K14/5409 , C07K14/5437 , C07K16/00 , C07K16/082 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/40 , C07K16/4291 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2319/00 , C07K2319/30 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2795/18122 , C12N2795/18134 , Y02A50/412 , Y02A50/467
摘要： The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array. The invention also provides a process for producing an antigen or antigenic determinant in an ordered and repetitive array. The ordered and repetitive antigen or antigenic determinant is useful in the production of vaccines for the treatment of infectious diseases, the treatment of allergies and as a pharmaccine to prevent or cure cancer and to efficiently induce self-specific immune responses, in particular antibody responses.
摘要翻译： 本发明涉及分子生物学，病毒学，免疫学和医学领域。 本发明提供包含有序重复抗原或抗原决定簇的组合物。 本发明还提供了以有序和重复阵列产生抗原或抗原决定簇的方法。 有序和重复的抗原或抗原决定簇可用于生产用于治疗感染性疾病，治疗过敏症和用作预防或治愈癌症并有效诱导自身特异性免疫应答，特别是抗体反应的药物的疫苗。
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12.发明授权公开(公告)号：US07229624B2
公开(公告)日：2007-06-12
申请号：US10733582
申请日：2003-12-12
IPC分类号： A61K39/385
CPC分类号： A61K39/00 , A61K2039/5256 , A61K2039/5258
摘要： The invention provides compositions and processes for the production of ordered and repetitive antigen or antigenic determinant arrays. The compositions of the invention are useful for the production of vaccines for the prevention of infectious diseases, the treatment of allergies and the treatment of cancers. Various embodiments of the invention provide for a virus, virus-like particle, viral capsid particle, phage or recombinant form thereof coated with any desired antigen in a highly ordered and repetitive fashion as the result of specific interactions. In one specific embodiment, a versatile new technology based on a cassette-type system (AlphaVaccine Technology) allows production of antigen coated viral particles. Other specific embodiments allow the production of antigen coated hepatitis B virus-like particles or antigen coated Measles virus-like particles.
摘要翻译： 本发明提供用于产生有序和重复抗原或抗原决定簇的组合物和方法。 本发明的组合物可用于生产用于预防感染性疾病，过敏症的治疗和癌症治疗的疫苗。 作为特定相互作用的结果，本发明的各种实施方案提供以高度有序和重复的方式包被任何所需抗原的病毒，病毒样颗粒，病毒衣壳颗粒，噬菌体或重组形式。 在一个具体实施方案中，基于盒式系统（AlphaVaccine Technology）的多功能新技术允许产生抗原包被的病毒颗粒。 其他具体实施方案允许产生抗原包被的乙型肝炎病毒样颗粒或抗原包被的麻疹病毒样颗粒。
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公开(公告)号：US06576443B2
公开(公告)日：2003-06-10
申请号：US09733042
申请日：2000-12-11
申请人： Frank Hennecke , Wolfgang A. Renner
发明人： Frank Hennecke , Wolfgang A. Renner
IPC分类号： C12Q168
CPC分类号： C12N15/85 , A01K2217/05 , A61K48/00 , C07K14/505 , C12N15/86 , C12N15/907 , C12N2770/36143 , C12N2800/30 , C12N2830/008 , C12N2830/42 , C12N2830/85 , C12N2840/20 , C12N2840/203
摘要： The present invention relates to methods for the modification of genomes of eukaryotic cells to alter the expression of endogenous genes. The invention also relates to recombinant eukaryotic host cells and polypeptides produced by the practice of the disclosed methods. The invention further relates to vector systems useful for modifying the genomes of eukaryotic cells to alter the expression of endogenous genes.
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14.发明授权Expression cloning processes for the discovery, characterization and isolation of genes encoding polypeptides with a predetermined property 失效用于发现，表征和分离编码具有预定特性的多肽的基因的表达克隆方法公开(公告)号：US06524792B1
公开(公告)日：2003-02-25
申请号：US09193707
申请日：1998-11-17
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12Q1/6897 , Y10S435/911 , Y10S435/912
摘要： The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such proteins or glycoproteins in mammalian cells and for facilitated purification of the novel secreted proteins or glycoproteins. Further, the invention provides for radioactive labelling of the novel proteins or glycoproteins, for rapid identification of sites of binding including animals and for rapid production of infective viral vectors for use in gene transfer.
摘要翻译： 本发明涉及用于检测，表征和分离编码具有所需性质（例如特定细胞定位）的蛋白质的核酸的方法。 本发明进一步提供了这些蛋白质或糖蛋白在哺乳动物细胞中的快速表达，并促进新分泌的蛋白质或糖蛋白的纯化。 此外，本发明提供新型蛋白质或糖蛋白的放射性标记，用于快速鉴定包括动物在内的结合位点，并快速产生用于基因转移的感染性病毒载体。
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15.发明授权Expression cloning processes for the discovery characterization, and isolation of genes encoding polypeptides with a predetermined property 失效用于发现表征的表达克隆过程，以及分离编码具有预定特性的多肽的基因公开(公告)号：US06197502B1
公开(公告)日：2001-03-06
申请号：US08972218
申请日：1997-11-17
IPC分类号： C12Q168
CPC分类号： C12N15/1086 , C12Q1/6897 , Y10S435/911 , Y10S435/912
摘要： The present invention is directed to a method for detection, characterization and isolation of nucleic acids encoding proteins of a desired property, such as a particular cellular localization. The invention further provides for rapid expression of such proteins or glycoproteins in mammalian cells and for facilitated purification of the novel secreted proteins or glycoproteins. Further, the invention provides for radioactive labelling of the novel proteins or glycoproteins, for rapid identification of sites of binding including animals and for rapid production of infective viral vectors for use in gene transfer.
摘要翻译： 本发明涉及用于检测，表征和分离编码具有所需性质（例如特定细胞定位）的蛋白质的核酸的方法。 本发明进一步提供了这些蛋白质或糖蛋白在哺乳动物细胞中的快速表达，并促进新分泌的蛋白质或糖蛋白的纯化。 此外，本发明提供新型蛋白质或糖蛋白的放射性标记，用于快速鉴定包括动物在内的结合位点，并快速产生用于基因转移的感染性病毒载体。
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