公开(公告)号：US10420749B2

公开(公告)日：2019-09-24

申请号：US15743894

申请日：2016-07-27

Applicant: Pfizer Inc.

Inventor： Klimentina Dimitrova Pencheva ,  Melissa J. Birch

IPC: A61K31/4162 ,  A61P35/00 ,  C07D498/18 ,  G01N21/65 ,  G01N23/20 ,  G01N24/08

Abstract: This invention relates to a crystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.

公开(公告)号：US20180235933A1

公开(公告)日：2018-08-23

申请号：US15743894

申请日：2016-07-27

Applicant: Pfizer Inc.

Inventor： Klimentina Dimitrova Pencheva ,  Melissa J. Birch

IPC: A61K31/4162 ,  A61P35/00

Abstract: This invention relates to acrystalline form of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-5-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h] [2,5,11]benzoxadiazacyclo-tetradecine-3-carbonitrile (lorlatinib) free base (Form 7). This invention also relates to pharmaceutical compositions comprising Form 7, and to methods of using Form 7 and such compositions in the treatment of abnormal cell growth, such as cancer, in a mammal.