公开(公告)号：US20230002498A1

公开(公告)日：2023-01-05

申请号：US17830324

申请日：2022-06-01

Applicant: Pfizer Inc.

Inventor： Siler Panowski ,  Tao Sai ,  Barbra Johnson Sasu ,  Surabhi Srivatsa Srinivasan ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  A61P35/00

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

公开(公告)号：US11987634B2

公开(公告)日：2024-05-21

申请号：US17830324

申请日：2022-06-01

Applicant: Pfizer Inc.

Inventor： Siler Panowski ,  Tao Sai ,  Barbra Johnson Sasu ,  Surabhi Srivatsa Srinivasan ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2875 ,  A61P35/00 ,  C07K16/2809 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

公开(公告)号：US11912776B2

公开(公告)日：2024-02-27

申请号：US17695769

申请日：2022-03-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien Kuo ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C07K14/705 ,  C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  C12N5/10 ,  C07K14/725 ,  A61K31/7076 ,  C12N15/63 ,  A61K35/17 ,  C12N5/0783 ,  A61K38/00

CPC classification number: C07K16/2878 ,  A61K31/7076 ,  A61K35/17 ,  A61K39/0011 ,  A61K39/46 ,  A61K39/4631 ,  A61K39/464417 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70578 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/10 ,  C12N15/63 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/5156 ,  C07K16/2863 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33 ,  C12N2510/02

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

公开(公告)号：US20220340671A1

公开(公告)日：2022-10-27

申请号：US17695769

申请日：2022-03-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien KUO ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00 ,  A61K31/7076 ,  C12N15/63 ,  A61K35/17 ,  C12N5/10 ,  C12N5/0783

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

公开(公告)号：US11377500B2

公开(公告)日：2022-07-05

申请号：US16264485

申请日：2019-01-31

Applicant: Pfizer Inc.

Inventor： Siler Panowski ,  Tao Sai ,  Barbra Johnson Sasu ,  Surabhi Srivatsa Srinivasan ,  Thomas John Van Blarcom

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00

Abstract: The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.

公开(公告)号：US11312782B2

公开(公告)日：2022-04-26

申请号：US16384719

申请日：2019-04-15

Applicant: Pfizer Inc.

Inventor： Tracy Chia-Chien Kuo ,  Bijan Andre Boldajipour ,  Javier Fernando Chaparro Riggers ,  Philippe Duchateau ,  Roman Ariel Galetto ,  Alexandre Juillerat ,  Thomas Charles Pertel ,  Arvind Rajpal ,  Barbra Johnson Sasu ,  Cesar Adolfo Sommer ,  Julien Valton ,  Thomas John Van Blarcom

IPC: C12N5/10 ,  C12N15/63 ,  C07K16/28 ,  C07K14/705 ,  C07K19/00 ,  C07K14/725 ,  A61K39/00 ,  A61K31/7076 ,  A61K35/17 ,  C12N5/0783 ,  A61K39/395 ,  A61K38/00

Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

公开(公告)号：US10793635B2

公开(公告)日：2020-10-06

申请号：US16017974

申请日：2018-06-25

Applicant: PFIZER INC.

Inventor： Tracy Chia-Chien Kuo ,  Javier Fernando Chaparro Riggers ,  Wei Chen ,  Amy Shaw-Ru Chen ,  Edward Derrick Pascua ,  Thomas John Van Blarcom ,  Leila Marie Boustany ,  Weihsien Ho ,  Yik Andy Yeung ,  Pavel Strop ,  Arvind Rajpal

IPC: A61K39/395 ,  C07K16/28 ,  A61K31/454 ,  A61K31/704 ,  A61K31/69 ,  A61K47/68 ,  A61K39/00

Abstract: The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.