-
公开(公告)号：US11814435B2
公开(公告)日：2023-11-14
申请号：US17005073
申请日：2020-08-27
申请人： PFIZER INC.
发明人： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68 , A61K39/00
CPC分类号： C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , C07K16/2803 , C07K16/2809 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K31/69 , A61K2300/00 , A61K31/704 , A61K2300/00 , A61K31/454 , A61K2300/00
摘要： The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
-
公开(公告)号：US20190233528A1
公开(公告)日：2019-08-01
申请号：US16264371
申请日：2019-01-31
申请人： Pfizer Inc.
发明人： Surabhi Srivatsa Srinivasan , Niranjana Aditi Nagarajan , Siler Panowski , Yoon Park , Tao Sai , Barbra Johnson SASU , Thomas John Van Blarcom , Mathilde Brunnhilde Dusseaux , Roman Ariel Galetto
IPC分类号： C07K16/28 , C07K14/725 , A61K39/00 , A61P35/02 , A61P35/04
CPC分类号： C07K16/2875 , A61K39/001129 , A61K39/001138 , A61K2039/5156 , A61P35/02 , A61P35/04 , C07K14/7051 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/02 , C07K2319/03 , C07K2319/33
摘要： The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).
-
公开(公告)号：US11155630B2
公开(公告)日：2021-10-26
申请号：US17129833
申请日：2020-12-21
申请人： PFIZER INC.
发明人： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K31/454 , A61K31/704 , A61K31/69 , A61K47/68 , A61K39/00
摘要： The present invention relates to bispecific antibodies that specific bind to BCMA (B-Cell Maturation Antigen) and CD3 (Cluster of Differentiation 3). Method of making the bispecific antibodies and method of using the bispecific antibodies for the treatment of multiple myeloma are also provided.
-
公开(公告)号：US10040860B2
公开(公告)日：2018-08-07
申请号：US15878344
申请日：2018-01-23
申请人： PFIZER INC.
发明人： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K47/68 , A61K31/69 , A61K31/704 , A61K39/00
CPC分类号： C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
-
公开(公告)号：US11673953B2
公开(公告)日：2023-06-13
申请号：US16802822
申请日：2020-02-27
发明人： Yi Zhang , Thomas John Van Blarcom , Siler Panowski , Silvia K. Tacheva-Grigorova , Barbra Johnson Sasu
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/2887 , C12N15/63 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2319/70
摘要： Provided herein are DLL3 binding agents and chimeric antigen receptors (CARs) comprising a DLL3 binding molecule that specifically binds to DLL3; and immune cells comprising these DLL3-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using DLL3-specific CARs, and immune cells comprising DLL3-specific CARs.
-
公开(公告)号：US20190233529A1
公开(公告)日：2019-08-01
申请号：US16264485
申请日：2019-01-31
申请人： Pfizer Inc.
发明人： Siler Panowski , Tao Sai , Barbra Johnson Sasu , Surabhi Srivatsa Srinivasan , Thomas John Van Blarcom
CPC分类号： C07K16/2875 , A61K2039/505 , A61P35/00 , C07K16/2809 , C07K2317/31 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies that specifically bind to CD70 (Cluster of Differentiation 70). The invention further provides bispecific antibodies that bind to CD70 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of CD70-mediated pathologies, including cancer.
-
公开(公告)号：US10294304B2
公开(公告)日：2019-05-21
申请号：US15085317
申请日：2016-03-30
申请人： PFIZER INC.
发明人： Tracy Chia-Chien Kuo , Bijan Andre Boldajipour , Javier Fernando Chaparro Riggers , Philippe Duchateau , Roman Galetto , Alexandre Juillerat , Thomas Charles Pertel , Arvind Rajpal , Barbra Johnson Sasu , Cesar Adolfo Sommer , Julien Valton , Thomas John Van Blarcom
IPC分类号： C07K16/28 , A61K39/395 , C12N15/63 , C07K14/725 , C07K14/705 , A61K39/00 , A61K31/7076 , A61K35/17 , A61K38/00
摘要： The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).
-
公开(公告)号：US09969809B2
公开(公告)日：2018-05-15
申请号：US15085644
申请日：2016-03-30
申请人： PFIZER INC.
发明人： Tracy Chia-Chien Kuo , Javier Fernando Chaparro Riggers , Wei Chen , Amy Shaw-Ru Chen , Edward Derrick Pascua , Thomas John Van Blarcom , Leila Marie Boustany , Weihsien Ho , Yik Andy Yeung , Pavel Strop , Arvind Rajpal
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395 , A61K31/454 , A61K31/704 , A61K47/48 , A61K31/69 , A61K39/00
CPC分类号： C07K16/2878 , A61K31/454 , A61K31/69 , A61K31/704 , A61K39/3955 , A61K39/39558 , A61K47/6801 , A61K47/6849 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to BCMA (B-Cell Maturation Antigen) and/or CD3 (Cluster of Differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the BCMA antibodies, compositions comprising the BCMA antibodies, and methods of using the BCMA antibodies and their conjugates for treating conditions associated with cells expressing BCMA (e.g., cancer or autoimmune disease). The invention further relates to heteromultimeric antibodies that specifically bind to CD3 and a tumor cell antigen, (e.g., bispecific antibodies that specifically bind to CD3 and BCMA). Compositions comprising such heteromultimeric antibodies, methods for producing and purifying such heterodimeric antibodies, and their use in diagnostics and therapeutics are also provided.
-
公开(公告)号：US20240101710A1
公开(公告)日：2024-03-28
申请号：US18468854
申请日：2023-09-18
发明人： Zea Melton , Tao Sai , Thomas John Van Blarcom
IPC分类号： C07K16/42 , A61K49/00 , C07K1/22 , C07K16/28 , C12N5/0783 , G01N33/569
CPC分类号： C07K16/4266 , A61K49/0058 , C07K1/22 , C07K16/2878 , C12N5/0636 , G01N33/56972 , C07K2317/622 , C12N2501/998
摘要： Provided herein are anti-idiotype antibodies that specifically recognize anti-BCMA antibody moieties, in particular, anti-BCMA antibody moieties present in recombinant receptors, including chimeric antigen receptors (CARs). The disclosure further relates to uses of anti-idiotype antibodies for specifically identifying and/or selecting cells expressing such recombinant receptors, such as anti-BCMA CAR T cells. The disclosure further relates to uses of anti-idiotype antibodies for specifically activating such cells.
-
公开(公告)号：US11702474B2
公开(公告)日：2023-07-18
申请号：US17120935
申请日：2020-12-14
申请人： Pfizer Inc.
发明人： Javier Fernando Chaparro Riggers , Shih-Hsun Chen , Sheng Ding , Pawel Kamil Dominik , Shahram Salek-Ardakani , Jessica Lynn Stanfield , Thomas John Van Blarcom
CPC分类号： C07K16/2827 , A61P35/00 , C07K16/2803 , A61K2039/505 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Antibodies that specifically bind to CD47 and antibodies that specifically bind to PD-L1 are provided, as well as CD47/PD-L1 bispecific antibodies. Also provided are uses of these antibodies, and related compositions and methods.
-
-
-
-
-
-
-
-
-
搜索结果
17 条记录 (耗时 0.031 秒)
