公开(公告)号：US09663526B2

公开(公告)日：2017-05-30

申请号：US14829753

申请日：2015-08-19

Applicant: Pfizer Inc.

Inventor： Andrew Fensome ,  Ariamala Gopalsamy ,  Brian S. Gerstenberger ,  Ivan Viktorovich Efremov ,  Zhao-Kui Wan ,  Betsy Pierce ,  Jean-Baptiste Telliez ,  John I. Trujillo ,  Liying Zhang ,  Li Xing ,  Eddine Saiah

IPC: A61K31/506 ,  C07D487/08 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D519/00

CPC classification number: A61K31/55 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D487/08 ,  C07D519/00

Abstract: A compound having the structure: or an acceptable salt thereof, wherein X is N or CR, where R is hydrogen, alkyl, etc.; A is selected from the group consisting of a bond, C═O, —SO2—, etc.; A′ is selected from the group consisting of a bond, C═O, etc.; Z is —(CH2)h— or a bond, etc.; R1 and R1′ are independently selected from the group consisting of hydrogen, alkyl, etc.; R2 is selected from hydrogen, alkyl, etc.; R3 is selected from the group consisting of hydrogen, and amino; R4 is monocyclic or bicyclic, etc.; R5 is independently selected from hydrogen, alkyl, etc.; h, j, k, m, n and q are integers as defined in the specification. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.