公开(公告)号：US07855227B2

公开(公告)日：2010-12-21

申请号：US12158491

申请日：2006-11-29

申请人： Florian Thaler ,  Mauro Napoletano ,  Cibele Sabido-David ,  Ermanno Moriggi ,  Carla Caccia ,  Laura Faravelli ,  Alessandra Restivo ,  Patricia Salvati

发明人： Florian Thaler ,  Mauro Napoletano ,  Cibele Sabido-David ,  Ermanno Moriggi ,  Carla Caccia ,  Laura Faravelli ,  Alessandra Restivo ,  Patricia Salvati

IPC分类号： A61K31/34 ,  C07D209/14

CPC分类号： C07D285/06 ,  C07C237/06 ,  C07C237/20 ,  C07C2601/02 ,  C07D211/58 ,  C07D213/30 ,  C07D213/38 ,  C07D213/64 ,  C07D231/12 ,  C07D233/64 ,  C07D261/12 ,  C07D295/185 ,  C07D307/14 ,  C07D307/52 ,  C07D333/20 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： 2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R0, R1, R2, R3, and R4 have the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described.

摘要翻译： 式（I）的2-苯基乙基氨基取代的甲酰胺衍生物; 其中J，W，R 0，R 1，R 2，R 3和R 4具有如本说明书中所定义的含义及其药学上可接受的盐，含有它们作为活性成分的药物组合物及其作为钠和/或钙通道调节剂用于预防 描述了将上述机制描述为发挥病理作用的各种病症，包括神经，精神，心血管，炎症，眼科，泌尿科和胃肠疾病。