公开(公告)号：US11305288B2

公开(公告)日：2022-04-19

申请号：US16774862

申请日：2020-01-28

Applicant: Plexium, Inc.

Inventor： Yi Zhang ,  Jesse Lu ,  Alex Price ,  Pengyu Yang ,  Kandaswamy Vijayan

IPC: B01L3/00 ,  C12M1/32

Abstract: Disclosed is an assay device comprising a high density of wells aligned thereon.

公开(公告)号：US10946383B2

公开(公告)日：2021-03-16

申请号：US16534922

申请日：2019-08-07

Applicant: Plexium, Inc.

Inventor： Kandaswamy Vijayan ,  Andrew Boyd MacConnell ,  Joseph Franklin Rokicki

IPC: B01L3/00 ,  C12N15/10 ,  C12Q1/6869 ,  C40B50/04 ,  C40B50/14 ,  C12Q1/6876 ,  C40B30/06 ,  C40B50/16 ,  C40B30/04

Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.

公开(公告)号：US10828643B2

公开(公告)日：2020-11-10

申请号：US16534886

申请日：2019-08-07

Applicant: Plexium, Inc.

Inventor： Kandaswamy Vijayan ,  Andrew Boyd MacConnell ,  Joseph Franklin Rokicki

IPC: C12N15/10 ,  C12Q1/6869 ,  C12Q1/6876 ,  B01L3/00 ,  C40B50/04 ,  C40B50/14 ,  C40B30/06 ,  C40B50/16 ,  C40B30/04

Abstract: This application provides a bead with a covalently attached chemical compound and a covalently attached DNA barcode and methods for using such beads. The bead has many substantially identical copies of the chemical compound and many substantially identical copies of the DNA barcode. The compound consists of one or more chemical monomers, where the DNA barcode takes the form of barcode modules, where each module corresponds to and allows identification of a corresponding chemical monomer. The nucleic acid barcode can have a concatenated structure or an orthogonal structure. Provided are method for sequencing the bead-bound nucleic acid barcode, for cleaving the compound from the bead, and for assessing biological activity of the released compound.