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公开(公告)号：US08114958B2
公开(公告)日：2012-02-14
申请号：US10589054
申请日：2005-02-11
Applicant: Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David Geoffrey Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine Marie Mack , Qing Lin
Inventor： Christopher J. Soares , Michael R. Hanley , Diana Y. Lewis , David Geoffrey Parkes , Carolyn M. Jodka , Kathryn S. Prickett , Soumitra S. Ghosh , Christine Marie Mack , Qing Lin
IPC: C07K19/00 , C07K14/435 , A61K38/16 , A61P3/04
CPC classification number: C07K14/575
Abstract: The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
Abstract translation: 本发明涉及肥胖相关多肽（ORPs），相关核酸，表达构建体，宿主细胞，并且涉及肥胖相关多肽的产生。 本发明的ORP包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。
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公开(公告)号：US20090186817A1
公开(公告)日：2009-07-23
申请号：US12293389
申请日：2007-03-21
Applicant: Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
Inventor： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC: A61K38/22 , C07K2/00 , C07K14/575
CPC classification number: A61K47/545 , A61K47/55 , A61K47/64
Abstract: Peptide-peptidase inhibitor conjugate molecules are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
Abstract translation: 公开了肽 - 肽酶抑制剂缀合物分子。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US20080305519A1
公开(公告)日：2008-12-11
申请号：US11709949
申请日：2007-02-23
Applicant: Qing Lin , Michael M. Madden
Inventor： Qing Lin , Michael M. Madden
IPC: C12P21/06 , C07K7/00 , C07D235/02
CPC classification number: C07K5/06026 , C07K5/0817 , C07K5/101 , C07K7/06
Abstract: An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing the tag to conjugate to the target protein. The tag may embody at least one structural feature of an ubiquitin C-terminus, and the structural feature may comprise a recognition sequence that is recognizable by an ubiquitin activating enzyme.
Abstract translation: 一种用于蛋白质标记的改进方法，包括提供合成小分子标签，提供待标记的靶蛋白的步骤，提供至少两种用于催化标签和靶蛋白之间的缀合反应的酶，孵育标签，蛋白质和 酶，并使标签与靶蛋白结合。 标签可以体现泛素C-末端的至少一个结构特征，并且结构特征可以包含可被泛素活化酶识别的识别序列。
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公开(公告)号：US20050255115A1
公开(公告)日：2005-11-17
申请号：US10478345
申请日：2002-05-23
Applicant: Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
Inventor： Hualiang Huang , Xin Jiang , Min Fang , Jie Feng , Ping Zhou , Xiaocong Yu , Qing Lin
IPC: A61K39/395 , C07K16/28 , C07K16/30 , C07K19/00 , C12N15/13 , C12N15/62 , C12N15/63 , C12P21/08 , G01N33/574 , C12N5/06
CPC classification number: C07K16/2809 , C07K16/3069 , C07K2317/31 , C07K2317/55 , C07K2317/565 , C07K2317/622
Abstract: The present invention provides an anti-ovarian cancer bispecific antibody. Said antibody includes two polypeptide domains connected by a polypeptide linker, one is anti-ovarian cancer antibody, or its Fab fragment, single complementarity determining region (CDR) antibody or single chain Fv (scFv) and the other is anti-CD3 antibody, or its Fab fragment, single CDR antibody or scFv. The present invention also provides DNA sequences encoding said antibody, an expression vector containing said DNA sequence, and a host cell containing said expression vector.
Abstract translation: 本发明提供了抗卵巢癌双特异性抗体。 所述抗体包括通过多肽接头连接的两个多肽结构域，一个是抗卵巢癌抗体或其Fab片段，单互补决定区（CDR）抗体或单链Fv（scFv），另一个是抗CD3抗体，或 其Fab片段，单CDR抗体或scFv。 本发明还提供编码所述抗体的DNA序列，含有所述DNA序列的表达载体和含有所述表达载体的宿主细胞。
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公开(公告)号：US20050244467A1
公开(公告)日：2005-11-03
申请号：US10837355
申请日：2004-04-30
Applicant: Thierry Nivaggioli , Jane Shiah , Qing Lin
Inventor： Thierry Nivaggioli , Jane Shiah , Qing Lin
CPC classification number: A61K9/0051 , A61K9/204 , A61K31/57 , A61K31/573 , A61K47/34
Abstract: Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
Abstract translation: 尺寸适于植入眼部或部位的可生物降解植入物以及用于治疗眼部病症的方法。 植入物以治疗有效量提供活性剂的延长释放一段时间在50天至1年或更长时间之间。
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Patent Agency Ranking
16.发明申请PEPTIDE-PEPTIDASE-INHIBITOR CONJUGATES AND METHODS OF MAKING AND USING SAME 失效肽 - 肽抑制剂结合物及其制备方法和使用方法公开(公告)号：US20100286365A1
公开(公告)日：2010-11-11
申请号：US12680539
申请日：2008-09-26
Applicant: Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
Inventor： Soumitra S. Ghosh , Josue Alfaro-Lopez , Lawrence J. D'Souza , Odile Esther Levy , Qing Lin , Christopher J. Soares
IPC: C07K1/10
CPC classification number: A61K47/64 , A61K47/545 , A61K47/55
Abstract: Peptide-peptidase inhibitor conjugate molecules and methods of manufacture thereof are disclosed. These conjugate molecules are useful as agents for the treatment and prevention of metabolic and cardiovascular diseases, disorders, and conditions. Such diseases, conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, insulin-resistance, obesity, and diabetes mellitus of any kind, and other diabetes-related disorders.
Abstract translation: 公开了肽肽酶抑制剂缀合物分子及其制备方法。 这些缀合物分子可用作治疗和预防代谢和心血管疾病，病症和病症的药剂。 这些疾病，病症和障碍包括但不限于高血压，血脂异常，心血管疾病，进食障碍，胰岛素抵抗，肥胖症和任何类型的糖尿病以及其它与糖尿病有关的疾病。
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公开(公告)号：US20080274952A1
公开(公告)日：2008-11-06
申请号：US10589054
申请日：2005-02-11
Applicant: Christopher J Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
Inventor： Christopher J Soares , Michael R. Hanley , Diana Yvonne Lewis , David Geoffrey Parkes , Carolyn Marie Jodka , Kathryn S. Prickett , Soumitra Ghosh , Christine Marie Mack , Qing Lin
CPC classification number: C07K14/575
Abstract: The present invention relates to obesity related polypeptides (ORPs), related nucleic acids, expression constructs, host cells, and processes production of the obesity related polypeptides. The ORPs of the invention include one or more amino acid sequence modifications. In addition, methods and compositions are disclosed to treat and prevent metabolic disorders such as obesity, diabetes, and increased cardiovascular risk.
Abstract translation: 本发明涉及肥胖相关多肽（ORPs），相关核酸，表达构建体，宿主细胞，并且涉及肥胖相关多肽的产生。 本发明的ORP包括一个或多个氨基酸序列修饰。 此外，公开了治疗和预防代谢紊乱如肥胖，糖尿病和增加的心血管风险的方法和组合物。
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公开(公告)号：US20080089228A1
公开(公告)日：2008-04-17
申请号：US11680607
申请日：2007-02-28
Applicant: Qing Lin , Bin Gan , Xiaoyun Jing
Inventor： Qing Lin , Bin Gan , Xiaoyun Jing
IPC: H04Q7/00
CPC classification number: H04L69/16 , H04L47/10 , H04L47/14 , H04L47/193 , H04L47/2441 , H04L47/2466 , H04L47/283 , H04L69/163 , H04W80/06
Abstract: A method to improve TCP throughput by separating TCP acknowledgment flow from TCP normal data flow in a wireless communications environment. This method creates dedicated signaling air interface link and signaling A10 link for TCP acknowledgment flow and assigns a higher priority value to TOS field of IP packets encapsulating TCP acknowledgments than those encapsulating TCP normal data.
Abstract translation: 一种通过在无线通信环境中将TCP确认流与TCP正常数据流分离来提高TCP吞吐量的方法。 该方法创建用于TCP确认流的专用信令空中接口链路和信令A10链路，并且为封装TCP确认的IP分组的TOS字段的TOS字段分配比封装TCP普通数据的IP分组更高的优先级值。
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公开(公告)号：US20070104000A1
公开(公告)日：2007-05-10
申请号：US11589164
申请日：2006-10-30
Applicant: Qing Lin , Kiran Dasoju
Inventor： Qing Lin , Kiran Dasoju
IPC: G11C29/00
CPC classification number: G11C29/027 , G11C29/72
Abstract: The present invention according to certain embodiments is directed to a method, device and apparatus for repairing a plurality of memory locations. The present invention includes providing a plurality of memory locations, providing a plurality of fuses coupled to the memory locations and loading fuse data into a data register from a plurality of read-only memory (ROM) devices thereby creating loaded fuse data. The present invention also provides loading a programming sequence of the memory device, wherein the programming sequence includes a plurality of memory addresses, and reading the loaded fuse data from the fuse register to a plurality of memory locations corresponding to the plurality of memory addresses.
Abstract translation: 根据某些实施例的本发明涉及用于修复多个存储器位置的方法，装置和装置。 本发明包括提供多个存储器位置，提供耦合到存储器位置的多个熔丝，并将熔丝数据从多个只读存储器（ROM）器件加载到数据寄存器中，从而产生加载的熔丝数据。 本发明还提供加载存储器件的编程序列，其中编程序列包括多个存储器地址，并将加载的熔丝数据从熔丝寄存器读取到对应于多个存储器地址的多个存储单元。
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20.发明授权公开(公告)号：US09264373B2
公开(公告)日：2016-02-16
申请号：US11994491
申请日：2005-07-01
Applicant: Lei Wan , Lars Robert Looström , Qing Lin
Inventor： Lei Wan , Lars Robert Looström , Qing Lin
IPC: H04J3/00 , H04L12/805 , H04J3/06 , H04L12/801 , H04L1/00
CPC classification number: H04L47/36 , H04J3/0682 , H04L1/0007 , H04L47/10
Abstract: The present invention relates to an arrangement for point-to-point transmission over links between first and second link (end) terminals in a system implementing time division duplex (TDD) and wherein information is sent over the links in frames divided into time slots. It is adapted to determine the lengths of the frames on a per link basis using one or more link parameters, the frame length hence being variable.
Abstract translation: 本发明涉及一种在实现时分双工（TDD）的系统中的第一和第二链路（终端）终端之间的链路上的点对点传输的装置，并且其中信息通过划分为时隙的帧中的链路发送。 其适于使用一个或多个链路参数在每个链路的基础上确定帧的长度，因此帧长度是可变的。
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