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公开(公告)号：US12065511B2
公开(公告)日：2024-08-20
申请号：US16818560
申请日：2020-03-13
IPC分类号： C07K5/10 , A61K38/06 , A61K38/07 , C07C229/26 , C07D209/16 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , C07K5/08 , C07K5/087 , C07K5/09 , C07K5/107 , C07K5/11 , G01N33/68
CPC分类号： C07K5/10 , A61K38/06 , A61K38/07 , C07C229/26 , C07D209/16 , C07K5/06 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/08 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/1016 , C07K5/1019 , G01N33/68
摘要： The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.
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公开(公告)号：US11939398B2
公开(公告)日：2024-03-26
申请号：US16325716
申请日：2017-08-16
申请人： Neuro-Bio Ltd
CPC分类号： C07K5/0821 , A61P25/28 , C07K5/0812 , C07K5/0817 , A61K38/00
摘要： The invention relates to neurodegenerative disorders, and in particular to novel peptides, peptidomimetics, compositions, therapies and methods for treating such conditions, for example Alzheimer's disease.
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公开(公告)号：US20240059734A1
公开(公告)日：2024-02-22
申请号：US18221140
申请日：2023-07-12
发明人： Guozhu Zheng , Mark J. Bamberger , Inese Smukste
IPC分类号： C07K5/09 , C07D271/06 , C07K5/072 , C07D413/06
CPC分类号： C07K5/0817 , C07D271/06 , C07K5/0815 , C07K5/06095 , C07D413/06 , C07B2200/05
摘要： Disclosed are non-natural peptides useful for the treatment and prevention of ischemia-reperfusion injury (e.g., cardiac ischemia-reperfusion injury) or myocardial infarction.
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公开(公告)号：US20230346874A1
公开(公告)日：2023-11-02
申请号：US18107640
申请日：2023-02-09
发明人： Liping Liu , Shibo Tang , Xiaoling Liang
CPC分类号： A61K38/06 , C07K5/0817 , A61K38/07 , C07K5/1016 , A61P27/02 , A61K45/06 , A61P27/12
摘要： The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US11673914B2
公开(公告)日：2023-06-13
申请号：US16750742
申请日：2020-01-23
IPC分类号： C07K5/09 , A61K47/64 , A61K51/08 , C07K7/06 , C07K7/64 , A61K9/08 , A61K38/17 , A61K51/06 , A61L26/00 , A61L27/00 , A61L27/22 , A61L31/04 , G01N1/00 , A61K38/06 , A61K38/08 , A61K38/12 , A61K39/395 , A61K9/06
CPC分类号： C07K5/0817 , A61K9/08 , A61K38/06 , A61K38/08 , A61K38/12 , A61K38/1709 , A61K39/3955 , A61K47/64 , A61K51/065 , A61K51/082 , A61K51/088 , A61L26/00 , A61L27/00 , A61L27/227 , A61L31/043 , C07K7/06 , C07K7/64 , G01N1/00 , A61K9/06 , A61L2300/252
摘要： Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH—CH(CH2—SO3H)COOH or Arg-Gly-NH—CH(CH2—SO3H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers, multimers, cyclic forms, linear forms, drug-conjugates, pro-drugs and their derivatives. Also disclosed are methods for making and using such compounds including methods for inhibiting integrins including but not necessarily limited to α5β1-Integrin, αvβ3-Integrin and αvβ5-Integrin, inhibiting cellular adhesion to RGD binding sites, preventing or treating viral or other microbial infections, inhibiting angiogenesis in tumors, retinal tissue or other tissues or delivering other diagnostic or therapeutic agents to RGD binding sites in human or animal subjects.
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公开(公告)号：US20190211057A1
公开(公告)日：2019-07-11
申请号：US16247489
申请日：2019-01-14
发明人： C. Allen Chang , Hsin-Ell Wang , Jia-Je Li , Shun-Fu Chang , Roy Chen-Chih Wu
CPC分类号： C07K5/0817 , A61K51/048 , A61K51/082 , C07K2319/01 , C12N9/78
摘要： The present invention provides a targeted prodrug enzyme fusion carrier comprising a targeted molecule and a prodrug enzyme. The targeted prodrug enzyme fusion carrier can effectively identify and bind to tumor cells and tumor-induced tumor angiogenesis. The targeted prodrug enzyme fusion carrier also has a targeted prodrug enzyme fusion protein and a theranostic system utilizing the method of in vivo nuclear medicine for the clinical diagnosis and treatment of individual patients with tumors.
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公开(公告)号：US20180244721A1
公开(公告)日：2018-08-30
申请号：US15729838
申请日：2017-10-11
发明人： Hazel H. SZETO , Peter W. SCHILLER
CPC分类号： C07K7/06 , A61K38/00 , C07K5/0817 , C07K5/10 , C07K5/1019
摘要： The disclosure provides aromatic-cationic peptide compositions and methods of preventing or treating disease using the same. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof
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公开(公告)号：US09988422B2
公开(公告)日：2018-06-05
申请号：US14347998
申请日：2012-09-28
CPC分类号： C07K5/0817 , A61K38/06 , A61K38/07 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of ARVD, including administering an effective amount of an aromatic-cationic peptide to a subject in need thereof. The methods include administering aromatic-cationic peptides to prevent or treat renal injury during the treatment of renal artery stenosis. The methods include administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
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公开(公告)号：US20180133281A1
公开(公告)日：2018-05-17
申请号：US15860120
申请日：2018-01-02
发明人： Amir Tamiz
IPC分类号： A61K38/06 , A61K9/00 , A61K38/08 , C07K5/093 , C07K5/097 , C07K5/083 , C07K5/087 , C07K5/09 , C07K7/06 , C07K5/10 , C07K5/08 , A61K45/06 , A61K38/07
CPC分类号： A61K38/06 , A61K9/0053 , A61K9/007 , A61K38/07 , A61K38/08 , A61K45/06 , C07K5/08 , C07K5/0806 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0823 , C07K5/0825 , C07K5/10 , C07K7/06
摘要： The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides methods for the treatment of excessive or undesirable permeability of a tissue by administering to a subject suffering from such a condition a composition comprising a peptide tight junction antagonist of the invention.
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公开(公告)号：US20180066015A1
公开(公告)日：2018-03-08
申请号：US15556804
申请日：2016-03-02
申请人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
发明人： James W. Janetka , Zhenfu Han , Peter Harris , Partha Karmakar
IPC分类号： C07K5/09 , C07K5/072 , C07D277/64 , A61K49/00 , A61K51/08 , A61K51/04 , C07B59/00 , C07K5/12 , C07K5/078 , C07K5/103 , C07K5/107
CPC分类号： C07K5/0815 , A61K38/00 , A61K47/64 , A61K49/0052 , A61K49/0056 , A61K51/0453 , A61K51/08 , C07B59/002 , C07B59/008 , C07B2200/05 , C07D277/64 , C07K5/06095 , C07K5/06156 , C07K5/0817 , C07K5/0821 , C07K5/1005 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K5/126 , G01N33/582 , G01N2800/7028
摘要： The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.
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