公开(公告)号：US20140142291A1

公开(公告)日：2014-05-22

申请号：US14045565

申请日：2013-10-03

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Hartmut Duefel ,  Dieter Heindl ,  Carina Horn ,  Thomas Meier ,  Rainer Schmuck

IPC: C07H19/207

CPC classification number: C07H19/207 ,  C12P19/32

Abstract: The disclosure concerns the enzymatic synthesis of stable analogues of nicotinamide adenine dinucleotide NAD/NADH and nicotinamide adenine dinucleotide phosphate NADP/NADPH, the so-called “carba-NADs”, i.e. analogues of NAD/NADH or NADP/NADPH, respectively, comprising a carbacyclic sugar instead of ribose.

Abstract translation: 本公开内容涉及烟酰胺腺嘌呤二核苷酸NAD / NADH和烟酰胺腺嘌呤二核苷酸磷酸NADP / NADPH的稳定类似物的酶合成，即所谓的“carba-NAD”，即NAD / NADH或NADP / NADPH的类似物，分别包含 碳环糖代替核糖。