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公开(公告)号:US20190314331A1
公开(公告)日:2019-10-17
申请号:US16452880
申请日:2019-06-26
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号:US10369134B2
公开(公告)日:2019-08-06
申请号:US16209412
申请日:2018-12-04
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号:US20190169123A1
公开(公告)日:2019-06-06
申请号:US16209263
申请日:2018-12-04
Applicant: Sunovion Pharmaceuticals Inc.
Inventor: John R. Snoonian , Harold Scott Wilkinson
IPC: C07D207/09
CPC classification number: C07D207/09 , C07B2200/13
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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公开(公告)号:US12161623B2
公开(公告)日:2024-12-10
申请号:US17977920
申请日:2022-10-31
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号:US11440921B2
公开(公告)日:2022-09-13
申请号:US17006101
申请日:2020-08-28
Applicant: Sunovion Pharmaceuticals Inc.
Inventor: Andrea Bauer , Nandkumar Nivritti Bhogle , Xiaoxia Chen , Shahla Jamzad , Robert Joseph Prytko , Kostas Saranteas , Michael Joseph Sizensky , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D495/04 , A61K9/20 , A61K45/06 , A61K31/381 , A61P25/18 , A61P25/00
Abstract: Provided are salts of (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine and various of crystal forms thereof, and compositions, medicaments, pharmaceutically acceptable formulations thereof, and methods of making same. In addition, provided are compounds comprising specific particle size distributions of crystalline (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine HCl and methods of making and modulating the particle size distributions.
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公开(公告)号:US11136304B2
公开(公告)日:2021-10-05
申请号:US16817749
申请日:2020-03-13
Applicant: Sunovion Pharmaceuticals Inc.
Inventor: Nandkumar Nivritti Bhogle , Takahiko Hashizuka , Robert Joseph Prytko , John R. Snoonian , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D311/76
Abstract: The present disclosure relates to salts of (R)-1-(8-fluoroisochroman-1-yl)-N-methylmethanamine, crystalline forms thereof, and methods of preparation thereof, which are useful in the treatment of CNS disorders.
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公开(公告)号:US20210061759A1
公开(公告)日:2021-03-04
申请号:US16994835
申请日:2020-08-17
Applicant: Sunovion Pharmaceuticals Inc.
Inventor: John R. Snoonian , Harold Scott Wilkinson , Haitao Zhang
IPC: C07D207/09
Abstract: The various aspects present inventions provide various crystalline forms of (S)-(−)-amisulpride, (R)-(+)-amisulpride, and solvates thereof and methods of making same. In various aspects, the inventions also provide methods of resolving racemic amisulpride.
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公开(公告)号:US10660875B1
公开(公告)日:2020-05-26
申请号:US16738261
申请日:2020-01-09
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号:US20190167635A1
公开(公告)日:2019-06-06
申请号:US16209412
申请日:2018-12-04
Applicant: Sunovion Pharmaceuticals Inc.
Abstract: Provided are compositions comprising unequal mixtures of (R)-amisulpride and (S)-amisulpride, or pharmaceutically acceptable salts thereof, where the amount of (R)-amisulpride is greater than the amount of (S)-amisulpride, compositions and medicaments comprising the same used for the treatment of various diseases and disorders, and methods of using same for the treatment of various diseases and disorders, including, but not limited to, dosage regimens. In addition, provided are various formulations thereof, including, but not limited to, formulations employing polymorphs of enantiomeric amisulpride.
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公开(公告)号:US20180071230A1
公开(公告)日:2018-03-15
申请号:US15631909
申请日:2017-06-23
Applicant: SUNOVION PHARMACEUTICALS INC.
Inventor: Sharon M. Laughlin , Michael J. Sizensky , Surendra P. Singh , Harold Scott Wilkinson , Cai Gu Huang , Philip James Bonasia , Susan S. D'Souza
IPC: A61K31/135 , C07C211/42 , A61K9/20 , A61K9/48
CPC classification number: A61K31/135 , A61K9/2018 , A61K9/4858 , C07C211/42
Abstract: Provided herein are pharmaceutical compositions comprising transnorsertraline, salts and polymorphic forms of transnorsertraline, methods of making the compositions, and methods for their use for the treatment of CNS diseases, including depression.
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