公开(公告)号：US20140356366A1

公开(公告)日：2014-12-04

申请号：US14290447

申请日：2014-05-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kwang Ho CHEONG ,  Seung Hyun Lee ,  Mi Young Cho ,  Young Jun Koh ,  Lin Powei ,  Christina Yi ,  Jae Woong Hwang

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/40

CPC classification number: C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.

Abstract translation: 一种目标膜蛋白质耗尽的方法，包括用双重结合分子处理细胞，所述双重结合分子包含结合驱动膜蛋白的第一结合结构域和结合靶膜蛋白的第二结合结构域，其中所述细胞包含细胞膜，以及 驱动膜蛋白和靶膜蛋白与靶膜蛋白定位的细胞膜相关联，并且当双重结合分子的第一结合结构域结合驱动膜蛋白时，其被内化为细胞并降解; 以及相关方法和组成。

公开(公告)号：US11166674B2

公开(公告)日：2021-11-09

申请号：US15636244

申请日：2017-06-28

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Kak Namkoong ,  Young Jun Koh ,  Yeol Ho Lee ,  Myoung Hoon Jung

IPC: A61B5/00 ,  A61B5/0408 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/282

Abstract: A wrist-type body composition measuring apparatus is provided to measure body composition conveniently. The wrist-type body composition measuring apparatus includes a main body comprising a measurer configured to measure body impedance of a user, and an analyzer configured to analyze a body composition of the user based on the measured body impedance; a strap connected to the main body and configured to be flexible; a first inner electrode and a second inner electrode which are provided on a rear surface of the main body to be in direct contact with the user; and a first outer electrode and a second outer electrode which are provided on a surface of the main body to be in contact with the user during measurement of the body composition, wherein the first outer electrode and the second outer electrode are each formed as a half ring and face each other with a gap therebetween.

公开(公告)号：US09902776B2

公开(公告)日：2018-02-27

申请号：US14446167

申请日：2014-07-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Mi Young Cho ,  Seung Hyun Lee ,  Kwang Ho Cheong ,  Young Jun Koh ,  Jung Wook Lee ,  Powei Lin ,  Jae Woong Hwang

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00

Abstract: An anti-EGFR scFV fragment, an anti-c-Met/anti-EGFR bispecific antibody including the same, and a method of preventing and/or treating a cancer using the same are provided.

公开(公告)号：US09730926B2

公开(公告)日：2017-08-15

申请号：US14600986

申请日：2015-01-20

Applicant: Samsung Electronics Co., Ltd.

Inventor： Powei Lin ,  Kwang Ho Cheong ,  Young Jun Koh ,  Jae-woong Hwang ,  Seung Hyun Lee ,  Jung Wook Lee

IPC: A61K31/496 ,  C07K16/28 ,  A61K45/06 ,  A61K31/506 ,  A61K31/517 ,  A61K39/00

CPC classification number: A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: Pharmaceutical composition including a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor and a method of preventing and/or treating cancer including co-administering a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor to a subject in need thereof.