公开(公告)号：US20170183401A1

公开(公告)日：2017-06-29

申请号：US15387198

申请日：2016-12-21

Applicant: Samsung Electronics Co., Ltd.

Inventor： Hongseok Jo ,  Sang Yeul Han ,  Joo-Hye Song ,  Yuhoi Kang ,  Young Jun Koh ,  Sang Chul Park ,  Hojun Lee

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92

Abstract: Provided is a method of decreasing blood sugar level or preventing and/or treating a hyperglycemia-related disease, including administering an anti-Ang2 antibody or an antigen-biding fragment thereof to a subject in need thereof.

公开(公告)号：US09359440B2

公开(公告)日：2016-06-07

申请号：US14444632

申请日：2014-07-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kwang Ho Cheong ,  Young Jun Koh ,  Min-Kyung Kim ,  Powei Lin ,  Seung Hyun Lee ,  Jung Wook Lee ,  Mi Young Cho ,  Jae Woong Hwang

IPC: C07K16/28 ,  C07K16/32 ,  C07K14/705

CPC classification number: C07K16/2863 ,  C07K14/705 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/33

Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.

Abstract translation: 包含与DARPin连接的双特异性嵌合蛋白，包括设计的锚蛋白重复蛋白（DARPin）和IgG抗体，scFv-Fc抗体片段或其组合; 使用该方法治疗或预防癌症的方法; 以及相关方法和组成。

公开(公告)号：US10420483B2

公开(公告)日：2019-09-24

申请号：US15363293

申请日：2016-11-29

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Yeol Ho Lee ,  Kak Namkoong ,  Myoung Hoon Jung ,  Young Jun Koh

IPC: A61B5/053 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/0408

Abstract: An apparatus and method for measuring a bioelectric impedance is provided. The apparatus may measure the bioelectric impedance using three electrodes. The apparatus may measure the bioelectric impedance by compensating for a change of a contact impedance.

公开(公告)号：US20150030596A1

公开(公告)日：2015-01-29

申请号：US14444632

申请日：2014-07-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kwang Ho CHEONG ,  Young Jun Koh ,  Min-Kyung Kim ,  Powei Lin ,  Seung Hyun Lee ,  Jung Wook Lee ,  Mi Young Cho ,  Jae Woong Hwang

IPC: C07K16/28 ,  C07K14/705

CPC classification number: C07K16/2863 ,  C07K14/705 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/30 ,  C07K2319/33

Abstract: A bispecific chimeric protein including a designed ankyrin repeat protein (DARPin), and an IgG antibody, an scFv-Fc antibody fragment, or a combination thereof, linked to the DARPin; a method for treating or preventing cancer using the same; and related methods and compositions.

Abstract translation: 包含与DARPin连接的双特异性嵌合蛋白，包括设计的锚蛋白重复蛋白（DARPin）和IgG抗体，scFv-Fc抗体片段或其组合; 使用该方法治疗或预防癌症的方法; 以及相关方法和组成。

公开(公告)号：US20150030599A1

公开(公告)日：2015-01-29

申请号：US14446167

申请日：2014-07-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Mi Young CHO ,  Seung Hyun Lee ,  Kwang Ho Cheong ,  Young Jun Koh ,  Jung Wook Lee ,  Powei Lin ,  Jae Woong Hwang

IPC: C07K16/28

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00

Abstract: An anti-EGFR scFV fragment, an anti-c-Met/anti-EGFR bispecific antibody including the same, and a method of preventing and/or treating a cancer using the same are provided.

Abstract translation: 提供抗EGFR scFV片段，包含其的抗c-Met /抗EGFR双特异性抗体，以及使用其的预防和/或治疗癌症的方法。

公开(公告)号：US10770172B2

公开(公告)日：2020-09-08

申请号：US15404657

申请日：2017-01-12

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Young Jun Koh ,  Kak Nam Koong ,  Yeol Ho Lee ,  Myoung Hoon Jung

IPC: G16H10/60 ,  G16H20/60

Abstract: An apparatus for health management includes an information collector configured to collect body composition information and characteristic information of a user, and a processor configured to determine a degree of muscle loss of the user based on the body composition information and the characteristic information of the user and provide a personalized health management program to the user based on the determined degree of muscle loss.

公开(公告)号：US10143749B2

公开(公告)日：2018-12-04

申请号：US14229308

申请日：2014-03-28

Applicant: Samsung Electronics Co., Ltd.

Inventor： Mi Young Cho ,  Powei Lin ,  Seung Hyun Lee ,  Kwang Ho Cheong ,  Young Jun Koh ,  Christina Yi ,  Jae Woong Hwang

IPC: C07K16/30 ,  C07K16/46 ,  A61K39/395 ,  C07K16/28 ,  C07K16/32

Abstract: There are provided an anti-c-Met/anti-Her2 bispecific antibody, and a method for preventing and/or treating cancer using the same.

公开(公告)号：US09657104B2

公开(公告)日：2017-05-23

申请号：US14231376

申请日：2014-03-31

Applicant: Samsung Electronics Co., Ltd.

Inventor： Mi Young Cho ,  Seung Hyun Lee ,  Kwang Ho Cheong ,  Powei Lin ,  Jae Woong Hwang ,  Christina Yi ,  Young Jun Koh

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/22

CPC classification number: C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/94

Abstract: There are provided an anti-c-Met/anti-EGFR bispecific antibody, a method for treating cancer using the same, and an anti-EGFR scFv fragment.

公开(公告)号：US09388243B2

公开(公告)日：2016-07-12

申请号：US14290447

申请日：2014-05-29

Applicant: Samsung Electronics Co., Ltd.

Inventor： Kwang Ho Cheong ,  Seung Hyun Lee ,  Mi Young Cho ,  Young Jun Koh ,  Lin Powei ,  Christina Yi ,  Jae Woong Hwang

IPC: C07K16/28 ,  C07K16/32

CPC classification number: C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.

Abstract translation: 一种目标膜蛋白质耗尽的方法，包括用双重结合分子处理细胞，所述双重结合分子包含结合驱动膜蛋白的第一结合结构域和结合靶膜蛋白的第二结合结构域，其中所述细胞包含细胞膜，以及 驱动膜蛋白和靶膜蛋白与靶膜蛋白定位的细胞膜相关联，并且当双重结合分子的第一结合结构域结合驱动膜蛋白时，其被内化为细胞并降解; 以及相关方法和组成。

公开(公告)号：US20150216972A1

公开(公告)日：2015-08-06

申请号：US14600986

申请日：2015-01-20

Applicant: Samsung Electronics Co., Ltd.

Inventor： Powei Lin ,  Kwang Ho Cheong ,  Young Jun Koh ,  Jae-woong Hwang ,  Seung Hyun Lee ,  Jung Wook Lee

IPC: A61K39/395 ,  C07K16/30 ,  A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  C07K16/28 ,  A61K45/06

CPC classification number: A61K31/496 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  A61K2300/00

Abstract: Pharmaceutical composition including a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor and a method of preventing and/or treating cancer including co-administering a bispecific anti-c-Met/anti-EGFR antibody and a c-Src inhibitor to a subject in need thereof.

Abstract translation: 包含双特异性抗c-Met /抗EGFR抗体和c-Src抑制剂的药物组合物和预防和/或治疗癌症的方法，包括共同施用双特异性抗c-Met /抗EGFR抗体和c -Src抑制剂用于需要的受试者。