公开(公告)号：US08178552B2

公开(公告)日：2012-05-15

申请号：US12536342

申请日：2009-08-05

申请人： Piotr Pawel Graczyk ,  Paschalis Dimopoulos ,  Afzal Khan ,  Gurpreet Singh Bhatia ,  Christopher Neil Farthing

发明人： Piotr Pawel Graczyk ,  Paschalis Dimopoulos ,  Afzal Khan ,  Gurpreet Singh Bhatia ,  Christopher Neil Farthing

IPC分类号： C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  A01N43/42 ,  A61K31/44

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.

摘要翻译： 本发明提供式（I）的化合物; 或其药学上可接受的盐，使用式（I）化合物或其药学上可接受的盐在抑制c-Jun N-末端激酶（JNK）活性中的用途以及在医药中的用途，特别是在治疗神经变性 疾病，炎性疾病和/或自身免疫性疾病。 本发明还提供制备所述式（I）化合物或其药学上可接受的盐以及含有它们的组合物的方法。