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1.发明申请DIAZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE 审中-公开DIAZAINDOLE DERIVATIVES及其在C-JUN N-TERMINAL KINASE的抑制中的用途公开(公告)号：US20110195951A1
公开(公告)日：2011-08-11
申请号：US13057448
申请日：2009-07-28
IPC分类号： A61K31/553 , C07D471/04 , A61K31/437 , C07D413/14 , C07D487/04 , A61K31/4985 , A61K31/5377 , A61K31/5025 , A61P25/00 , A61P29/00 , A61P19/02
CPC分类号： C07D487/04 , C07D471/04
摘要： The invention relates to diazaindole derivatives represented by the general formula (I): where A, E, G, R1, R2, R3 and R4 are defined herein, or pharmaceutically acceptable salts thereof, their use in the inhibition of c-Jun N-terminal kinase (JNK) activity, their use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases, autoimmune diseases and/or organ failure. The invention also provides processes for the manufacture of said diazaindole derivatives and compositions containing them.
摘要翻译： 本发明涉及由通式（I）表示的二氮杂吲哚衍生物：其中A，E，G，R1，R2，R3和R4如本文所定义，或其药学上可接受的盐，其用于抑制c-Jun N- 末端激酶（JNK）活性，它们在医学中的用途，特别是治疗神经变性疾病，炎性疾病，自身免疫性疾病和/或器官衰竭。 本发明还提供了制备所述二氮杂吲哚衍生物和含有它们的组合物的方法。
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![3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS](/abs-image/US/2011/07/07/US20110166173A1/abs.jpg.150x150.jpg)
2.发明申请3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS 审中-公开3,5-DISUBSTUTUTED 1H-吡咯[2,3-B]吡啶作为JNK抑制剂公开(公告)号：US20110166173A1
公开(公告)日：2011-07-07
申请号：US10591551
申请日：2005-03-03
IPC分类号： A61K31/437 , C07D471/04 , A61P29/00 , A61P19/00 , A61P31/00 , A61P9/00 , A61P25/28 , A61P25/16 , A61P7/06 , A61P1/04
CPC分类号： C07D471/04
摘要： The present invention provides novel compounds of forumula (I) and their use in the inhibition of c-Jun N-terminal kinases. The present invention further provides the use of these compounds in medicine, in particular in the prevention and/or treatment of neurodegenerative disorders related to apoptosis and/or inflammation.
摘要翻译： 本发明提供了新颖的化合物（I）及其在抑制c-Jun N-末端激酶中的用途。 本发明进一步提供这些化合物在药物中的用途，特别是在预防和/或治疗与凋亡和/或炎症相关的神经变性疾病中的用途。
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3.发明授权7-Azaindole derivatives and their use in the inhibition of c-Jun N-terminal kinase 有权7-Azaindole衍生物及其在c-Jun N-末端激酶抑制中的应用公开(公告)号：US08178552B2
公开(公告)日：2012-05-15
申请号：US12536342
申请日：2009-08-05
申请人： Piotr Pawel Graczyk , Paschalis Dimopoulos , Afzal Khan , Gurpreet Singh Bhatia , Christopher Neil Farthing
发明人： Piotr Pawel Graczyk , Paschalis Dimopoulos , Afzal Khan , Gurpreet Singh Bhatia , Christopher Neil Farthing
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
摘要翻译： 本发明提供式（I）的化合物; 或其药学上可接受的盐，使用式（I）化合物或其药学上可接受的盐在抑制c-Jun N-末端激酶（JNK）活性中的用途以及在医药中的用途，特别是在治疗神经变性 疾病，炎性疾病和/或自身免疫性疾病。 本发明还提供制备所述式（I）化合物或其药学上可接受的盐以及含有它们的组合物的方法。
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4.发明申请公开(公告)号：US20100069358A1
公开(公告)日：2010-03-18
申请号：US12536354
申请日：2009-08-05
申请人： Piotr Pawel GRACZYK , Paschalis DIMOPOULOS , Christopher Neil FARTHING , Gurpreet Singh BHATIA , Afzal KHAN
发明人： Piotr Pawel GRACZYK , Paschalis DIMOPOULOS , Christopher Neil FARTHING , Gurpreet Singh BHATIA , Afzal KHAN
IPC分类号： A61K31/553 , A61K31/5377 , A61K31/496 , C07D267/10 , C07D413/14 , C07D417/14 , A61P9/04 , A61P3/10 , A61P19/02
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
摘要翻译： 本发明提供式（I）的化合物; 或其药学上可接受的盐在抑制c-Jun N-末端激酶（JNK）活性，特别是在治疗神经变性疾病，炎性疾病和/或自身免疫疾病中。 本发明还提供制备所述式（I）化合物或其药学上可接受的盐以及含有它们的组合物的方法。
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5.发明申请7-AZAINDOLE DERIVATIVES AND THEIR USE IN THE INHIBITION OF C-JUN N-TERMINAL KINASE 有权七嗪衍生物及其在C-JUN N末端激酶抑制剂中的应用公开(公告)号：US20100069354A1
公开(公告)日：2010-03-18
申请号：US12536342
申请日：2009-08-05
申请人： Piotr Pawel GRACZYK , Paschalis DIMOPOULOS , Afzal KHAN , Gurpreet Singh BHATIA , Christopher Neil FARTHING
发明人： Piotr Pawel GRACZYK , Paschalis DIMOPOULOS , Afzal KHAN , Gurpreet Singh BHATIA , Christopher Neil FARTHING
IPC分类号： A61K31/397 , C07D471/02 , A61K31/437 , C07D413/14 , A61K31/5377 , C07D401/14 , A61K31/496 , C07D243/08 , A61K31/551 , C07D267/10 , A61K31/553 , C07D267/22 , A61P25/00 , A61P29/00 , A61P37/06 , A61P19/02
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof, the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and the use in medicine and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of said compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
摘要翻译： 本发明提供式（I）的化合物; 或其药学上可接受的盐，使用式（I）化合物或其药学上可接受的盐在抑制c-Jun N-末端激酶（JNK）活性中的用途以及在医药中的用途，特别是在治疗神经变性 疾病，炎性疾病和/或自身免疫性疾病。 本发明还提供制备所述式（I）化合物或其药学上可接受的盐以及含有它们的组合物的方法。
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公开(公告)号：US07951802B2
公开(公告)日：2011-05-31
申请号：US12536354
申请日：2009-08-05
申请人： Piotr Pawel Graczyk , Paschalis Dimopoulos , Christopher Neil Farthing , Gurpreet Singh Bhatia , Afzal Khan
发明人： Piotr Pawel Graczyk , Paschalis Dimopoulos , Christopher Neil Farthing , Gurpreet Singh Bhatia , Afzal Khan
IPC分类号： A61K31/535 , A61K31/497 , A61K31/44 , C07D413/14 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a compound of formula (I); or a pharmaceutically acceptable salt thereof in the inhibition of c-Jun N-terminal kinase (JNK) activity and particularly in the treatment of neurodegenerative disorders, inflammatory diseases and/or and autoimmune diseases. The invention also provides processes for the manufacture of compounds of formula (I) or a pharmaceutically acceptable salt thereof and compositions containing them.
摘要翻译： 本发明提供式（I）的化合物; 或其药学上可接受的盐在抑制c-Jun N-末端激酶（JNK）活性，特别是在治疗神经变性疾病，炎性疾病和/或自身免疫疾病中。 本发明还提供了制备式（I）化合物或其药学上可接受的盐和含有它们的组合物的方法。
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公开(公告)号：US07652137B2
公开(公告)日：2010-01-26
申请号：US10548162
申请日：2004-03-05
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
摘要翻译： 本发明提供式（I）的新型取代的氮杂二氢吲哚中间体及其合成方法。 提供了用于制备5-取代的7-氮杂吲哚和5-取代的7-氮杂吲哚的新的取代的氮杂二氢吲哚中间体（I）。
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