公开(公告)号：US20050026255A1

公开(公告)日：2005-02-03

申请号：US10926083

申请日：2004-08-26

申请人： John Morser ,  Qingyu Wu ,  Wei Yan

发明人： John Morser ,  Qingyu Wu ,  Wei Yan

IPC分类号： C12Q1/37 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/64

CPC分类号： C12Q1/37 ,  A01K2217/075

摘要： The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.

摘要翻译： 本发明涉及包含一个或多个卷曲的corin并且具有各种活性的corin多肽，其包括例如丝氨酸蛋白酶活性和原-ANF转化活性，LDLR，SRCR重复序列，丝氨酸蛋白酶催化结构域如人和小鼠corin 。 本发明还涉及在治疗，诊断和研究中使用这些核酸和多肽的方法。 例如，Corin的核酸和多肽可用于鉴定其活性的调节剂，在模拟人类疾病的动物模型中，以及治疗涉及corin的肾，心血管和其他病症的方法。