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11 条记录 (耗时 0.018 秒)

    Corin for Treating Obesity and Diabetes
    1.
    发明申请
    Corin for Treating Obesity and Diabetes 审中-公开
    Corin治疗肥胖和糖尿病

    公开(公告)号：US20110160128A1

    公开(公告)日：2011-06-30

    申请号：US12935228

    申请日：2009-03-25

    申请人： Qingyu Wu ,  Jingjing Jiang ,  Wei Wang

    发明人： Qingyu Wu ,  Jingjing Jiang ,  Wei Wang

    IPC分类号： A61K38/17 ,  A61K31/711 ,  A61P3/06

    CPC分类号： A61K38/482

    摘要： Provided herein are methods of inhibiting agouti or agouti-related protein (AGRP) in a cell or in an individual in need thereof, comprising administering to the cell or the individual an effective amount of an agent that induces corin expression, activity or a combination thereof in the cell or individual. The invention also provides a method of treating obesity in an individual in need thereof comprising administering to the individual an effective amount of an agent that enhances corin expression, activity or a combination thereof in the individual. Further provided is a method of treating diabetes type II in an individual in need thereof comprising administering to the individual an effective amount of an agent that enhances corin expression, activity or a combination thereof in the individual.

    摘要翻译： 本文提供了抑制细胞或有需要的个体中的agouti或agouti相关蛋白（AGRP）的方法，包括向细胞或个体施用有效量的诱导corin表达，活性或其组合的药剂 在细胞或个体。 本发明还提供了治疗有需要的个体中的肥胖症的方法，其包括向个体施用有效量的增强个体中的Corin表达，活性或其组合的药剂。 进一步提供了一种在有需要的个体中治疗II型糖尿病的方法，其包括向个体施用有效量的在个体中增强corin表达，活性或其组合的药剂。

    Method for producing biodiesel using high-cell-density cultivation of microalga Chlorella protothecoides in bioreactor
    2.
    发明申请
    Method for producing biodiesel using high-cell-density cultivation of microalga Chlorella protothecoides in bioreactor 审中-公开
    使用生物反应器中微藻藻样本的高细胞密度培养生产生物柴油的方法

    公开(公告)号：US20090211150A1

    公开(公告)日：2009-08-27

    申请号：US12080666

    申请日：2008-04-04

    申请人： Qingyu Wu ,  Wenguang Zhou ,  Wei Xiong

    发明人： Qingyu Wu ,  Wenguang Zhou ,  Wei Xiong

    IPC分类号： C10L1/18

    CPC分类号： C12N1/12 ,  C11B1/10 ,  C11C3/003 ,  C12P7/649 ,  Y02E50/13 ,  Y02P30/20

    摘要： A method is provided to produce biodiesel from algae using a strain of microalga chlorella protothecoids, by screening a specific strain with characteristics of high yield of biomass and high oil content, cultivating the screened strain for high-cell-density growth for up to 108 grams of dry cell weight per liter of the suspension in a bioreactor using solutions containing carbohydrates as feed, harvesting and drying the high density cultivated algal cells to extract oil from the dried algal cells, and producing the biodiesel by reaction of catalyzed transesterification using the extracted oil as feedstock.

    摘要翻译： 提供一种通过筛选具有高生物量和高油含量特征的特异性菌株，通过使用微藻类小球藻原型菌株从藻类生产生物柴油的方法，培养用于高细胞密度生长的筛选菌株高达108克 使用含有碳水化合物作为饲料的溶液，收获和干燥高密度培养的藻类细胞以从干燥的藻类细胞中提取油，并且通过使用提取的油的催化酯交换反应生产生物柴油，生物反应器中每升悬浮液的干细胞重量 作为原料。

    Novel modified corin molecules having substitute activation sequences and uses thereof
    3.
    发明申请
    Novel modified corin molecules having substitute activation sequences and uses thereof 失效
    具有替代激活序列的新型修饰的corin分子及其用途

    公开(公告)号：US20050003416A1

    公开(公告)日：2005-01-06

    申请号：US10865978

    申请日：2004-06-09

    申请人： Qingyu Wu

    发明人： Qingyu Wu

    IPC分类号： C12N9/64 ,  C12N15/57 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C12N9/6424 ,  Y10S435/975

    摘要： This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.

    摘要翻译： 本发明涉及包含替代活化序列的新型修饰的corin分子或其片段或衍生物。 修饰的corin分子在替代活化序列处被切割，从而产生表现出天然存在的野生型corin分子的功能活性的活化的corin分子或其片段或衍生物。 修饰的corin分子可用于治疗各种疾病或病症，包括充血性心力衰竭和急性心肌梗塞。

    Knockout mice and their progeny with a disrupted hepsin gene
    4.
    发明授权
    Knockout mice and their progeny with a disrupted hepsin gene 失效
    敲除小鼠及其具有破坏的hepsin基因的后代

    公开(公告)号：US5981830A

    公开(公告)日：1999-11-09

    申请号：US000846

    申请日：1997-12-30

    申请人： Qingyu Wu ,  Jasper E. Sadler

    发明人： Qingyu Wu ,  Jasper E. Sadler

    IPC分类号： A01K67/027 ,  C12N15/09 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63

    CPC分类号： A01K67/0275 ,  A01K2217/05 ,  A01K2217/075

    摘要： The present invention provides a transgenic mouse comprising a disrupted hepsin gene. In particular, the invention provides methods of making the transgenic mouse comprising the disrupted hepsin gene by utilizing a hepsin targeting vector for homologous recombination in mouse embryonic stem cells. Also, nucleotide and amino acid hepsin sequences are disclosed.

    摘要翻译： 本发明提供了包含破坏的hepsin基因的转基因小鼠。 特别地，本发明提供了通过在小鼠胚胎干细胞中利用hepsin靶向载体同源重组制备包含破坏的hepsin基因的转基因小鼠的方法。 此外，公开了核苷酸和氨基酸hepsin序列。

    Corin As A Marker For Heart Failure
    5.
    发明申请
    Corin As A Marker For Heart Failure 审中-公开
    Corin作为心力衰竭标记物

    公开(公告)号：US20110306069A1

    公开(公告)日：2011-12-15

    申请号：US13202275

    申请日：2010-02-19

    申请人： Qingyu Wu ,  Shenghan Chen ,  Edward Plow ,  Ningzheng Dong ,  Changgeng Ruan

    发明人： Qingyu Wu ,  Shenghan Chen ,  Edward Plow ,  Ningzheng Dong ,  Changgeng Ruan

    IPC分类号： G01N33/535

    CPC分类号： G01N33/6893 ,  G01N2800/325 ,  G01N2800/56

    摘要： The invention is a method of assessing whether an individual is afflicted with congestive heart failure (CHF) comprising comparing the level of corin or portion thereof in the individual to the level of corin or portion thereof in a control, wherein a decrease in the level of corin or portion thereof in the individual compared to the level of corin or portion thereof in the control indicates that the individual is afflicted with CHF. The methods described herein can be also be used to determine the severity of CHF in an individual, whether an individual's treatment for CHF is effective and whether an individual is at risk of developing CHF.

    摘要翻译： 本发明是一种评估个体是否患有充血性心力衰竭（CHF）的方法，其包括将个体中的corin或其部分的水平与对照中的corin或其部分的水平进行比较，其中， 与对照中的角质层或其部分相比，个体中的corin或其部分表明个体患有CHF。 本文所述的方法也可用于确定个体中CHF的严重性，个体对CHF的治疗是否有效以及个体是否处于发展CHF的风险中。

    Method for producing biodiesel from an alga
    7.
    发明申请
    Method for producing biodiesel from an alga 审中-公开
    从藻类生产生物柴油的方法

    公开(公告)号：US20090298159A1

    公开(公告)日：2009-12-03

    申请号：US12313455

    申请日：2008-11-20

    申请人： Qingyu Wu ,  Wei Xiong

    发明人： Qingyu Wu ,  Wei Xiong

    IPC分类号： C12N1/12 ,  C07C69/52

    CPC分类号： C12N1/12 ,  C10G2300/1011 ,  C10L1/026 ,  C11B1/10 ,  C11C3/003 ,  C12P7/649 ,  Y02E50/13 ,  Y02P30/20

    摘要： A method is provided to produce biodiesel from algae using a two-stage, autotrophic and heterotrophic cultivations of chlorella for biodiesel production. This method includes a sequence of procedures: cultivating photoautotrophic algae, concentrating cells and then transferring them to a fermentor for heterotrophic cultivation. During the photoautotrophic cultivation stage, the culture is exposed to a light source, such as sunlight with carbon dioxide obtained from a carbon dioxide source or from air. antibacterial agents may be added to prevent contamination from undesired microorganisms. Organic carbons are added during heterotrophic cultivation stage. Fermentation conditions are optimized for maximizing lipid synthesis. High biomass is achieved to about 108 g/L with lipid content reaching about 52% of dry cell weight. After cultivation, biodiesel is made through extraction and transesterification of algae lipids.

    摘要翻译： 提供了一种用藻类生产生物柴油的方法，用于生物柴油生产的小球藻的两阶段，自养和异养培养。 该方法包括一系列程序：培养光自养藻类，浓缩细胞，然后将其转移到发酵罐进行异养培养。 在光自养培养阶段期间，将培养物暴露于来自二氧化碳源或空气中的二氧化碳等光源，例如阳光。 可以加入抗菌剂以防止不想要的微生物的污染。 在异养培养阶段加入有机碳。 优化发酵条件以使脂质合成最大化。 高生物量达到约108g / L，脂质含量达到干细胞重量的约52％。 培养后，通过藻类脂质的提取和酯交换制备生物柴油。

    Corin, a serine protease
    9.
    发明申请
    Corin, a serine protease 审中-公开
    Corin，丝氨酸蛋白酶

    公开(公告)号：US20050026255A1

    公开(公告)日：2005-02-03

    申请号：US10926083

    申请日：2004-08-26

    申请人： John Morser ,  Qingyu Wu ,  Wei Yan

    发明人： John Morser ,  Qingyu Wu ,  Wei Yan

    IPC分类号： C12Q1/37 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/64

    CPC分类号： C12Q1/37 ,  A01K2217/075

    摘要： The present invention relates to a corin polypeptide which contains one or more frizzled corin and possesses various activities, including, e.g., serin protease activity and a pro-ANF converting activity, LDLR, SRCR repeats, serine protease catalytic domains such as human and mouse corin. The invention further relates to methods of using such nucleic acids and polypeptides in therapeutics, diagnostics, and research. For example, the nucleic acids and polypeptides of corin can be utilized in methods to identify modulators of its activity, in animal models to mimic human disease, and to treat kidney, cardiovascular, and other conditions in which corin is involved.

    摘要翻译： 本发明涉及包含一个或多个卷曲的corin并且具有各种活性的corin多肽，其包括例如丝氨酸蛋白酶活性和原-ANF转化活性，LDLR，SRCR重复序列，丝氨酸蛋白酶催化结构域如人和小鼠corin 。 本发明还涉及在治疗，诊断和研究中使用这些核酸和多肽的方法。 例如，Corin的核酸和多肽可用于鉴定其活性的调节剂，在模拟人类疾病的动物模型中，以及治疗涉及corin的肾，心血管和其他病症的方法。

    Modified corin molecules having substitute activation sequences and uses thereof
    10.
    发明授权
    Modified corin molecules having substitute activation sequences and uses thereof 失效
    具有替代活化序列的修饰的corin分子及其用途

    公开(公告)号：US07176013B2

    公开(公告)日：2007-02-13

    申请号：US10865978

    申请日：2004-06-09

    申请人： Qingyu Wu

    发明人： Qingyu Wu

    IPC分类号： C12N9/64 ,  C12N15/57 ,  C12N15/62 ,  C12N15/79 ,  A61K38/48

    CPC分类号： C12N9/6424 ,  Y10S435/975

    摘要： This invention relates to novel modified corin molecules, or fragments or derivatives thereof, comprising a substitute activation sequence. The modified corin molecules are cleaved at the substitute activation sequence, thereby generating activated corin molecules, or fragments or derivatives thereof, that exhibit the functional activity of naturally occurring, wild-type corin molecules. The modified corin molecules can be used to treat a variety of diseases or disorders, including congestive heart failure and acute myocardial infarction.

    摘要翻译： 本发明涉及包含替代活化序列的新型修饰的corin分子或其片段或衍生物。 修饰的corin分子在替代活化序列处被切割，从而产生表现出天然存在的野生型corin分子的功能活性的活化的corin分子或其片段或衍生物。 修饰的corin分子可用于治疗各种疾病或病症，包括充血性心力衰竭和急性心肌梗塞。