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11.发明申请公开(公告)号：US20180118854A1
公开(公告)日：2018-05-03
申请号：US15853164
申请日：2017-12-22
发明人： Kazuki Kikuchi , Mitsuhiro Yoshida , Junichi Matsubara , Tatsuya Yamashita , Akira Kitamura , Naosuke Maruyama
IPC分类号： C08B13/00 , C09D101/32
CPC分类号： C08B13/00 , C09D7/20 , C09D7/65 , C09D101/32
摘要： Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS.
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12.发明授权公开(公告)号：US09884922B2
公开(公告)日：2018-02-06
申请号：US15449725
申请日：2017-03-03
发明人： Kazuki Kikuchi , Mitsuhiro Yoshida , Junichi Matsubara , Tatsuya Yamashita , Akira Kitamura , Naosuke Maruyama
IPC分类号： C08B13/00 , C09D101/32 , C09D7/00
CPC分类号： C08B13/00 , C09D7/20 , C09D7/65 , C09D101/32
摘要： Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS.
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13.发明申请公开(公告)号：US20170260296A1
公开(公告)日：2017-09-14
申请号：US15449725
申请日：2017-03-03
发明人： Kazuki Kikuchi , Mitsuhiro Yoshida , Junichi Matsubara , Tatsuya Yamashita , Akira Kitamura , Naosuke Maruyama
IPC分类号： C08B13/00 , C09D7/00 , C09D101/32
CPC分类号： C08B13/00 , C09D7/20 , C09D7/65 , C09D101/32
摘要： Provided are hypromellose acetate succinate (HPMCAS) which exhibits high solubility and can suppress generation of undissolved materials when dissolved in a solvent; an HPMCAS-containing composition; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having a ratio of 2-position MS to 3-position MS of 1.2 or less, wherein the 2-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 2-position carbon of each glucose unit of the HPMCAS has been directly replaced, and the 3-position MS means a molar substitution of hydroxypropyl group by which a hydrogen atom of a hydroxyl group on 3-position carbon of each glucose unit of the HPMCAS has been directly replaced; a composition comprising the HPMCAS and a solvent; and the method for producing the HPMCAS.
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公开(公告)号：US20210130498A1
公开(公告)日：2021-05-06
申请号：US17083617
申请日：2020-10-29
IPC分类号： C08B3/16
摘要： There is provided a method for producing hydroxypropyl methyl cellulose phthalate (HPMCP), including an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCP; a precipitation step of precipitating the HPMCP by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCP; and a washing and recovery step of washing the HPMCP in the suspension and recovering the washed HPMCP. Further, there is provided HPMCP having yellowness at 20° C. of 10.0 or less, as determined in a 10% by mass solution of the HPMCP in acetone.
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公开(公告)号：US20210024656A1
公开(公告)日：2021-01-28
申请号：US17066543
申请日：2020-10-09
IPC分类号： C08B13/00 , A61K47/38 , A61K9/28 , A61K9/50 , A61K31/525
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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公开(公告)号：US20200181291A1
公开(公告)日：2020-06-11
申请号：US16789598
申请日：2020-02-13
IPC分类号： C08B13/00 , A61K31/525 , A61K9/50 , A61K9/28 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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公开(公告)号：US20170283514A1
公开(公告)日：2017-10-05
申请号：US15471224
申请日：2017-03-28
IPC分类号： C08B13/00 , A61K9/28 , A61K31/525 , A61K9/50
CPC分类号： C08B13/00 , A61K9/2866 , A61K9/5042 , A61K9/5089 , A61K31/525 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.
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18.发明授权Method for dehydrating hydrous low-substituted hydroxypropyl cellulose and method for producing low-substituted hydroxypropyl cellulose by using same 有权脱水含水低取代羟丙基纤维素的方法和使用它的低取代羟丙基纤维素的制造方法公开(公告)号：US09428590B2
公开(公告)日：2016-08-30
申请号：US14454964
申请日：2014-08-08
摘要： Reduction of the energy burden in a step of drying hydrous low-substituted hydroxypropyl cellulose (L-HPC), reduction of water content of a cake obtained by dehydration, and others are targeted. More specifically, provided is a method for dehydrating hydrous L-HPC with a compression type dehydrator by feeding the hydrous L-HPC to a screw conveyer connected to the inlet of the dehydrator, including steps of: starting the operation of the conveyer to fill the conveyer and the dehydrator with the hydrous L-HPC, starting the operation of the filled dehydrator, and feeding the hydrous L-HPC to the conveyer, while discharging dehydrated L-HPC from an outlet of the dehydrator, wherein a feed rate of feeding the hydrous L-HPC to the conveyer is equal to a discharge rate of discharging the dehydrated L-HPC in terms of net weight of cellulose ether, and a method for producing L-HPC by using the above method.
摘要翻译： 干燥含水低取代羟丙基纤维素（L-HPC）的步骤中的能量负荷的降低，脱水得到的滤饼的水分含量的降低等。 更具体地，提供了一种通过将水合L-HPC进料到连接到脱水机的入口的螺旋输送机上的压缩型脱水机来脱水含水L-HPC的方法，包括以下步骤：开始输送机的操作以填充 输送机和脱水器与水合L-HPC开始，开始填充脱水器的操作，并且将水合L-HPC输送到输送机，同时从脱水器的出口排放脱水的L-HPC，其中进料速率 对于输送机的含水L-HPC等于脱水的L-HPC以纤维素醚的净重排出的排出量，以及使用上述方法生产L-HPC的方法。
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