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17 条记录 (耗时 0.036 秒)

    Quinoline derivatives, their production and use
    11.
    发明授权
    Quinoline derivatives, their production and use 失效
    喹啉衍生物，其生产和使用

    公开(公告)号：US6087503A

    公开(公告)日：2000-07-11

    申请号：US152514

    申请日：1998-09-14

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Satoshi Sasaki

    IPC分类号： C07D215/56

    CPC分类号： C07D215/56

    摘要： The present compounds are intermediates for the preparation of quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

    摘要翻译： 本发明化合物是用于制备喹啉衍生物的中间体和具有促性腺激素释放激素拮抗活性的组合物，其用作预防或治疗若干激素依赖性疾病例如性激素依赖性癌症（例如前列腺癌， 子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）有效; 可用作男性或女性避孕药，作为排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用于调节畜牧业动物的发情周期，作为改善食用肉质量或促进动物生长的药剂，以及用于促进鱼类产卵的药剂。

    Thienopyridine compounds which have useful pharmaceutical activity
    12.
    发明授权
    Thienopyridine compounds which have useful pharmaceutical activity 失效
    具有有用药物活性的噻吩并吡啶化合物

    公开(公告)号：US5744479A

    公开(公告)日：1998-04-28

    申请号：US779608

    申请日：1997-01-07

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Masataka Harada ,  Satoshi Sasaki

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Masataka Harada ,  Satoshi Sasaki

    IPC分类号： C07D495/04 ,  A61K31/33 ,  C07D419/02

    CPC分类号： C07D495/04

    摘要： The present thienopyrimidine derivatives and compositions having gonadotropin-releasing hormone antagonistic activity are useful as propylactics or therapeutic agents for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals; and as agents for promoting spawning in fish.

    摘要翻译： 本发明的噻吩并嘧啶衍生物和具有促性腺激素释放激素拮抗活性的组合物可用作预防或治疗若干激素依赖性疾病的丙型或治疗剂，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌，乳腺癌 ，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）有效; 可用作男性或女性避孕药，作为排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用于调节畜牧业动物的发情周期，作为提高食用肉质量或促进动物生长的药剂; 并作为促进鱼类产卵的代理商。

    Condensed-ring thiophene derivatives, their production and use
    13.
    发明授权
    Condensed-ring thiophene derivatives, their production and use 失效
    缩环噻吩衍生物，其生产和使用

    公开(公告)号：US06514988B1

    公开(公告)日：2003-02-04

    申请号：US09672777

    申请日：2000-09-29

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Koichi Kato ,  Shuji Hinuma

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Koichi Kato ,  Shuji Hinuma

    IPC分类号： A61K31437

    CPC分类号： C07D495/04

    摘要： A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

    摘要翻译： 促性腺激素释放激素拮抗组合物，其包含任选取代的稠合双环化合物，其由同质或杂的5至7元环和同质或异构的5至7元环组成，作为用于预防或 治疗几种激素依赖性疾病，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前综合征 ，囊性卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）是有效的; 可作为男性或女性的避孕方法，作为女性的排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用作调整动物饲养领域的发情周期，作为提高食用肉质量或促进动物生长的药剂; 作为鱼类产卵促销的代理人是有用的。

    Condensed-ring thiophene derivatives, their production and use
    14.
    发明授权
    Condensed-ring thiophene derivatives, their production and use 失效
    缩环噻吩衍生物，其生产和使用

    公开(公告)号：US5817819A

    公开(公告)日：1998-10-06

    申请号：US454304

    申请日：1995-06-16

    申请人： Shuichi Furuya ,  Nobuo Choh ,  Koichi Kato ,  Shuji Hinuma

    发明人： Shuichi Furuya ,  Nobuo Choh ,  Koichi Kato ,  Shuji Hinuma

    IPC分类号： A61K31/38 ,  A61K31/44 ,  A61K31/505 ,  A61K31/55 ,  A61P5/04 ,  C07D495/04

    CPC分类号： C07D495/04

    摘要： A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

    摘要翻译： PCT No.PCT / JP95 / 00728 Sec。 371日期：1995年6月16日 102（e）日期1995年6月16日PCT提交1995年4月14日PCT公布。 出版物WO95 / 28405 日期1995年10月26日发明促性腺激素释放激素拮抗组合物，其包含任选取代的稠合双环化合物，其由同质或杂的5至7元环和同质或异构的5至7元环组成，作为丙基或治疗 用于预防或治疗几种激素依赖性疾病的药剂，例如性激素依赖性癌症（例如前列腺癌，子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟青春期 ，闭经，经前综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）是有效的; 可作为男性或女性的避孕方法，作为女性的排卵诱导剂; 可以通过使用由于其施用停止而产生的反弹效应而用作不育处理剂; 可用作调整动物饲养领域的发情周期，作为提高食用肉质量或促进动物生长的药剂; 作为鱼类产卵促销的代理人是有用的。