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17 条记录 (耗时 0.037 秒)

    Indole derivative compounds and drugs containing the compounds as the active ingredient
    11.
    发明申请
    Indole derivative compounds and drugs containing the compounds as the active ingredient 审中-公开
    吲哚衍生物化合物和含有这些化合物作为活性成分的药物

    公开(公告)号：US20060089353A1

    公开(公告)日：2006-04-27

    申请号：US10548089

    申请日：2004-03-05

    申请人： Maki Iwahashi ,  Atsushi Naganawa ,  Toshihiko Nishiyama ,  Toshihiko Nagase ,  Fumio Nambu

    发明人： Maki Iwahashi ,  Atsushi Naganawa ,  Toshihiko Nishiyama ,  Toshihiko Nagase ,  Fumio Nambu

    IPC分类号： A61K31/538 ,  C07D413/02

    CPC分类号： C07D413/12

    摘要： An indole derivative compound represented by formula (I) (wherein the symbols in the formula are as mentioned in the specification) and a salt thereof Since the compounds represented by formula (I) binds to PGD2 receptors and shows antagonistic activity, they are believed to be useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, systemic mast cell activating disorder, anaphylaxis shock, airway contraction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis, urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleep disorder) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, autoimmune disease, chronic articular rheumatism, pleuritis, ulcerative colitis and irritable bowel syndrome.

    摘要翻译： 由式（I）表示的吲哚衍生物化合物（其中式中的符号如说明书中所述）及其盐由于式（I）表示的化合物与PGD 2 N 2受体结合， 它们被认为可用于预防和/或治疗过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘和食物过敏），系统性肥大细胞增多症，全身性肥大细胞活化障碍等疾病， 过敏性休克，气道收缩，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎，荨麻疹），由于行为伴随而产生的疾病（如白内障，视网膜脱离，炎症，感染和睡眠障碍） 瘙痒（如搔痒），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，自身免疫性疾病 关节炎风湿病，胸膜炎，溃疡性结肠炎和肠易激综合征。

    Carboxyoic acid compounds and drugs containing the compounds as the active ingredient
    15.
    发明申请
    Carboxyoic acid compounds and drugs containing the compounds as the active ingredient 有权
    羧甲酸化合物和含有化合物的药物作为活性成分

    公开(公告)号：US20050222216A1

    公开(公告)日：2005-10-06

    申请号：US10507885

    申请日：2003-03-06

    申请人： Maki Iwahashi ,  Kaoru Kobayashi ,  Fumio Nambu

    发明人： Maki Iwahashi ,  Kaoru Kobayashi ,  Fumio Nambu

    IPC分类号： A61P1/04 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P17/00 ,  A61P25/06 ,  A61P25/20 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D209/12 ,  C07D265/36 ,  C07D307/80 ,  C07D319/20 ,  C07D327/06 ,  A61K31/44 ,  A61K31/195 ,  A61K31/277

    CPC分类号： C07D319/20 ,  C07D209/12 ,  C07D265/36 ,  C07D307/80 ,  C07D327/06

    摘要： A carboxylic acid compound represented by formula (I): (meanings of the symbols in the formula are as mentioned in the specification) and a pharmaceutical agent comprising the compound. Since the compound represented by formula (I) binds to a DP receptor and shows antagonistic activity for the DP receptor, it is useful for prevention and/or treatment of diseases such as allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, urticaria, eczema, diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which is generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

    摘要翻译： 由式（I）表示的羧酸化合物：（式中符号的含义如说明书中所述）和包含该化合物的药剂。 由于式（I）表示的化合物与DP受体结合，对DP受体具有拮抗作用，因此可用于预防和/或治疗过敏性疾病（如过敏性鼻炎，过敏性结膜炎，特应性皮炎， 支气管哮喘和食物过敏），系统性肥大细胞增多症，伴有系统性肥大细胞活化的疾病，过敏性休克，支气管收缩，荨麻疹，湿疹，伴有瘙痒的疾病（如特应性皮炎和荨麻疹），疾病（如白内障，视网膜脱离，炎症 ，感染和睡眠障碍），其由伴随瘙痒的行为（例如搔抓和殴打），炎症，慢性阻塞性肺疾病，缺血再灌注损伤，脑血管意外，慢性类风湿性关节炎，胸膜炎，溃疡性结肠炎和 喜欢。

    Indole derivatives, process for preparation of the same and use thereof
    17.
    发明授权
    Indole derivatives, process for preparation of the same and use thereof 失效
    吲哚衍生物，其制备方法及其用途

    公开(公告)号：US06743793B2

    公开(公告)日：2004-06-01

    申请号：US10220806

    申请日：2002-12-13

    申请人： Kazuhiko Torisu ,  Kaoru Kobayashi ,  Fumio Nambu

    发明人： Kazuhiko Torisu ,  Kaoru Kobayashi ,  Fumio Nambu

    IPC分类号： C07D20900

    CPC分类号： C07D401/12 ,  A61K31/404 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/422 ,  A61K31/423 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5383 ,  A61K31/5415 ,  C07D209/08 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12

    摘要： Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis, and the like.

    摘要翻译： 由式（I）表示的吲哚衍生物:(其中所有符号在描述中描述），其制备方法和包含其作为活性成分的DP受体拮抗剂。 由于式（I）化合物与DP受体结合并拮抗DP受体，它们可用于预防和/或治疗疾病，例如过敏性疾病（过敏性鼻炎，过敏性结膜炎，特应性皮炎，支气管哮喘， 食物过敏等，系统性肥大细胞增多症;由于系统性肥大细胞活化引起的疾病，过敏性休克，支气管收缩，荨麻疹，湿疹等），伴有瘙痒的疾病（特应性皮炎，荨麻疹等），行为引起的继发性疾病 行为，殴打等）（白内障，视网膜脱离，炎症，感染，睡眠障碍等），炎症，慢性阻塞性肺病，缺血再灌注障碍，脑血管障碍，类风湿性关节炎并发溃疡性结肠炎等的胸膜炎 。