公开(公告)号：US06319935B1

公开(公告)日：2001-11-20

申请号：US09542216

申请日：2000-04-04

Applicant: Stephen A. Munk ,  Michael E. Garst ,  James A. Burke

Inventor： Stephen A. Munk ,  Michael E. Garst ,  James A. Burke

IPC: A61K31425

CPC classification number: C07D413/12 ,  C07D233/50 ,  C07D263/28 ,  C07D277/18

Abstract: A compound of formula I in which: ring A is one of the five alternative multi-cyclic rings as shown wherein a dotted line adjacent to a bond indicates that a single bond or a double bond may be present at that position; X is nitrogen, oxygen or sulfur; R is hydrogen, lower straight or branched chain alkyl of 1 to 6 carbon atoms, or lower straight or branched chain alkenyl of 2 to 6 carbon atoms, a cycloaliphatic ring of 3 to 6 carbon atoms, phenyl optionally mono- or di-substituted with hydroxy, halogen, alkyl of 1 to 3 carbon atoms or alkoxy of 1 to 2 carbon atoms, or methylenedioxyphenyl; or a stereoisomer, or a pharmaceutically acceptable salt thereof. These compounds have &agr;2 receptor blocking activity and hence find use in the treatment or palliation of elevated intraocular pressure, non insulin-dependent diabetes, male impotence and obesity.

Abstract translation: 式Iin化合物，其中：环A是所示的五个替代多环之一，其中与键相邻的虚线表示在该位置可能存在单键或双键; X是氮，氧或硫; R为氢，1至6个碳原子的较低直链或支链烷基，或2至6个碳原子的较低直链或支链烯基，3至6个碳原子的脂环族环，任选被一个或二个取代 羟基，卤素，1至3个碳原子的烷基或1至2个碳原子的烷氧基，或亚甲二氧基苯基; 或其立体异构体或其药学上可接受的盐。这些化合物具有α2受体阻断活性，因此可用于治疗或缓解升高的眼内压，非胰岛素依赖性糖尿病，男性阳ence和肥胖。

公开(公告)号：US5149754A

公开(公告)日：1992-09-22

申请号：US417367

申请日：1991-03-18

Applicant: George D. Green ,  Stephen A. Munk ,  Darryl K. Barnes

Inventor： George D. Green ,  Stephen A. Munk ,  Darryl K. Barnes

IPC: C08F220/22 ,  C08F222/12 ,  D06M15/263 ,  D06M15/277

CPC classification number: D06M15/263 ,  C08F220/22 ,  C08F222/12 ,  D06M15/277 ,  Y10T428/2969

Abstract: The present invention relates to non-halogenated hydrocarbon polymeric compositions which impart durable stain resistance to fibrous substrates, particularly nylon containing articles. In addition, it relates to fluorine containing polymeric compositions which impart durable stain resistance to fibrous substrates as above. It relates also to processes in which such substrates are treated so as to impart durable stain resistance to them. It relates further to a manufacturing process for preparing the compositions of the invention.

Abstract translation: 本发明涉及对纤维基材，特别是含尼龙制品赋予耐久耐污性的非卤代烃聚合物组合物。 此外，它涉及如上所述赋予纤维基材耐久耐污性的含氟聚合物组合物。 它还涉及处理这样的基底以赋予它们耐久性耐污性的方法。 它进一步涉及制备本发明组合物的制备方法。

公开(公告)号：US5006408A

公开(公告)日：1991-04-09

申请号：US512227

申请日：1990-04-19

Applicant: George D. Green ,  Stephen A. Munk ,  Darryl K. Barnes

Inventor： George D. Green ,  Stephen A. Munk ,  Darryl K. Barnes

IPC: C08F220/22 ,  C08F222/12 ,  D06M15/263 ,  D06M15/277

CPC classification number: D06M15/263 ,  C08F220/22 ,  C08F222/12 ,  D06M15/277 ,  Y10T428/2969

Abstract: The present invention relates to non-halogenated hydrocarbon polymeric compositions which impart durable stain resistance to fibrous substrates, particularly nylon containing articles. In addition, it relates to fluorine containing polymeric compositions which impart durable stain resistance to fibrous substrates as above. It relates also to processes in which such substrates are treated so as to impart durable stain resistance to them. It relates further to a manufacturing process for preparing the compositions of the invention.

Abstract translation: 本发明涉及对纤维基材，特别是含尼龙制品赋予耐久耐污性的非卤代烃聚合物组合物。 此外，它涉及如上所述赋予纤维基材耐久耐污性的含氟聚合物组合物。 它还涉及处理这样的基底以赋予它们耐久性耐污性的方法。 它进一步涉及制备本发明组合物的制备方法。

公开(公告)号：US4699812A

公开(公告)日：1987-10-13

申请号：US935873

申请日：1986-11-28

Applicant: Stephen A. Munk ,  Thomas P. Malloy

Inventor： Stephen A. Munk ,  Thomas P. Malloy

IPC: D06M13/256 ,  B05D3/02

CPC classification number: D06M13/256 ,  Y10T428/23986

Abstract: Fibers containing free amino groups, and especially polyamide fibers, can be made resistant to certain stains, especially those resulting from food grade dyes, by contacting the fiber with a solution of an aliphatic sulfonic acid containing 8 to 24 carbon atoms. Branched chain aliphatic sulfonic acids are more effective than the linear aliphatic sulfonic acids, and branching at the carbon bearing the sulfonic acid group is more effective than branching at any other carbon. Contacting the fiber with the solution of the aliphatic sulfonic acid needs to be done under acidic conditions, most preferably at a pH between 0.5 to 5.0.

Abstract translation: 含有游离氨基，特别是聚酰胺纤维的纤维可以通过使纤维与含有8-24个碳原子的脂族磺酸的溶液接触而使某些污渍，特别是由食品级染料产生的污渍。 支链脂族磺酸比线性脂肪族磺酸更有效，而在含有磺酸基团的碳上支链比任何其它碳上的分支更有效。 将纤维与脂肪族磺酸溶液接触需要在酸性条件下进行，最优选在0.5至5.0之间的pH。