公开(公告)号：US20120121572A1

公开(公告)日：2012-05-17

申请号：US13320000

申请日：2010-05-14

申请人： Matteo D'Este ,  Giovanni Gennari

发明人： Matteo D'Este ,  Giovanni Gennari

IPC分类号： A61K31/737 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P11/06 ,  A61K38/47 ,  A61P35/00 ,  A61K38/02 ,  A61P31/22 ,  A61P7/02 ,  A61K38/43 ,  A61K38/48 ,  C08B37/08 ,  A61P37/06

CPC分类号： C08B37/00 ,  A61K8/735 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/136 ,  A61K31/737 ,  A61K38/47 ,  A61K45/06 ,  A61Q1/06 ,  A61Q11/00 ,  C12Y302/01035 ,  A61K2300/00

摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.

摘要翻译： 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和消炎）的调节剂的新颖且令人惊奇的用途，因此使用HAS来制备用于主题的新药 用于预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现HAS在调节这些特定蛋白质的活性方面的排他能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经证实 HAS对疱疹病毒，巨细胞病毒和水泡性口炎病毒的不同类型和毒株的意想不到的高活性。 最后，本发明的另一个目的是使用HAS作为抗炎性质的药物的皮肤吸收促进剂。