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14 条记录 (耗时 0.019 秒)

    Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
    11.
    发明申请
    Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof 有权
    糖皮质激素受体，AP-1和/或NF-kB活性的调节剂及其用途

    公开(公告)号：US20050176749A1

    公开(公告)日：2005-08-11

    申请号：US11034635

    申请日：2005-01-13

    申请人： Bingwei Yang

    发明人： Bingwei Yang

    IPC分类号： A61K31/426 ,  A61K31/4745 ,  C07D277/44 ,  C07D277/46 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/02

    CPC分类号： C07D417/12 ,  C07D277/46 ,  C07D417/08

    摘要： A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) its stereoisomers thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, where Z is S, O or NH; and R, R1, R2 Ra, Rb, Rc, Rd, Z, A and B are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

    摘要翻译： 提供了一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有 式（I）其立体异构体，或其溶剂合物或其药学上可接受的盐，其中Z为S，O或NH; 和R 1，R 1，R 2，R 2，R 2，R 2，R 2， >，R d，Z，A和B在本文中定义。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

    Modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof
    13.
    发明申请
    Modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof 有权
    糖皮质激素受体，AP-1和/或NF-kB活性的调节剂及其用途

    公开(公告)号：US20060154975A1

    公开(公告)日：2006-07-13

    申请号：US11330748

    申请日：2006-01-12

    申请人： Bingwei Yang ,  Lidia Doweyko ,  Arthur Doweyko

    发明人： Bingwei Yang ,  Lidia Doweyko ,  Arthur Doweyko

    IPC分类号： A61K31/421 ,  A61K31/426 ,  A61K31/4166

    CPC分类号： C07D277/46 ,  C07D233/90 ,  C07D277/56

    摘要： A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I): where X is S, O or N; Z is —T—COOR1 or —T—COR1; and T, R, R1, Ra, Rb, Rc, Rd, Z, A and B are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.

    摘要翻译： 提供了一类新型非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性的调节相关的疾病，包括肥胖症，糖尿病，炎症和免疫疾病，并且具有 式（I）：其中X为S，O或N; Z是-T-COOR 1或-T-COR 1; 和T，R，R 1，R 2，R 2，R b，R d，R d， 本文定义了Z，A和B。 还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。