公开(公告)号：US20240360113A1

公开(公告)日：2024-10-31

申请号：US18682750

申请日：2022-06-09

Applicant: Texas Heart Institute

Inventor： Robert V. MARKET ,  Ronald J. BIEDIGER ,  Frederick MEECE

IPC: C07D409/12 ,  A61K31/137 ,  A61K31/381 ,  A61K31/422 ,  C07D213/89 ,  C07D277/56 ,  C07D413/14 ,  C07D513/04

CPC classification number: C07D409/12 ,  A61K31/137 ,  A61K31/381 ,  A61K31/422 ,  C07D213/89 ,  C07D277/56 ,  C07D413/14 ,  C07D513/04

Abstract: N,N-disubstituted arylamine compounds and to their use as integrin agonists for enhancing binding of integrin-expressing cells to integrin-binding ligands or receptors.

公开(公告)号：US20240262825A1

公开(公告)日：2024-08-08

申请号：US18602482

申请日：2024-03-12

Applicant: BIONOMICS LIMITED

Inventor： Belinda HUFF ,  Courtney HOLLIS ,  Hamish TOOP ,  Nathan KUCHEL ,  Lorna Helen MITCHELL ,  Rajinder SINGH ,  Thomas AVERY ,  Celine MICHAUT-SIMON ,  Jean-Marie CONTRERAS ,  Christophe MORICE

IPC: C07D471/04 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D239/34 ,  C07D241/24 ,  C07D249/10 ,  C07D271/06 ,  C07D277/56 ,  C07D487/04

CPC classification number: C07D471/04 ,  C07D213/81 ,  C07D213/82 ,  C07D231/14 ,  C07D239/34 ,  C07D241/24 ,  C07D249/10 ,  C07D271/06 ,  C07D277/56 ,  C07D487/04

Abstract: The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.

公开(公告)号：US20240239749A1

公开(公告)日：2024-07-18

申请号：US18497879

申请日：2023-10-30

Applicant: Escient Pharmaceuticals, Inc.

Inventor： Marion Lanier ,  Marcus Boehm ,  Liming Huang ,  Esther Martinborough ,  Marcos Sainz ,  Brandon Selfridge ,  Adam Yeager

IPC: C07D213/73 ,  C07C255/60 ,  C07D209/08 ,  C07D231/14 ,  C07D239/48 ,  C07D239/94 ,  C07D277/56 ,  C07D277/62 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D471/04

CPC classification number: C07D213/73 ,  C07C255/60 ,  C07D209/08 ,  C07D231/14 ,  C07D239/48 ,  C07D239/94 ,  C07D277/56 ,  C07D277/62 ,  C07D401/12 ,  C07D403/04 ,  C07D405/04 ,  C07D471/04

Abstract: Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compound having structure (I):






or a pharmaceutically acceptable salt, isomer, hydrate, solvate or isotope thereof, wherein D, W, Z, R1, R2 and R3 are as defined herein. Pharmaceutical compositions containing such compounds, as well as the compounds themselves, are also provided.

公开(公告)号：US12023319B2

公开(公告)日：2024-07-02

申请号：US17478192

申请日：2021-09-17

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Stefan Bäurle ,  Adam James Davenport ,  Christopher Stimson ,  Jens Nagel ,  Nicole Schmidt ,  Andrea Rotgeri ,  Ina Gröticke ,  Alexandra Rausch ,  Juergen Klar ,  Thomas Dyrks

IPC: A61K31/381 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4965 ,  A61P3/04 ,  A61P3/10 ,  A61P13/10 ,  A61P19/02 ,  A61P25/02 ,  A61P29/00 ,  A61P35/00 ,  C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D241/12 ,  C07D277/56 ,  C07D333/28 ,  C07D333/38 ,  C07D333/58 ,  C07D405/04 ,  C07D495/04

CPC classification number: A61K31/381 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4164 ,  A61K31/426 ,  A61K31/4365 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/4965 ,  A61P3/04 ,  A61P3/10 ,  A61P13/10 ,  A61P19/02 ,  A61P25/02 ,  A61P29/00 ,  A61P35/00 ,  C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D241/12 ,  C07D277/56 ,  C07D333/28 ,  C07D333/38 ,  C07D333/58 ,  C07D405/04 ,  C07D495/04

Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease as a sole agent or in combination with other active ingredients.

公开(公告)号：US11919839B2

公开(公告)日：2024-03-05

申请号：US17238529

申请日：2021-04-23

Applicant: Valo Health, Inc.

Inventor： Kenneth W. Bair ,  Nicholas Barczak ,  Bingsong Han ,  David R. Lancia, Jr. ,  Cuixian Liu ,  Matthew W. Martin ,  Pui Yee Ng ,  Aleksandra Rudnitskaya ,  Jennifer R. Thomason ,  Mary-Margaret Zablocki ,  Xiaozhang Zheng

IPC: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10

CPC classification number: C07C259/06 ,  A61K31/185 ,  A61K31/277 ,  A61K31/397 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/417 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/438 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/451 ,  A61K31/495 ,  A61K31/5377 ,  C07D207/10 ,  C07D207/267 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D209/46 ,  C07D211/16 ,  C07D211/58 ,  C07D213/56 ,  C07D213/65 ,  C07D213/75 ,  C07D213/81 ,  C07D215/12 ,  C07D221/20 ,  C07D231/14 ,  C07D231/18 ,  C07D233/36 ,  C07D233/38 ,  C07D233/68 ,  C07D235/14 ,  C07D235/30 ,  C07D239/20 ,  C07D239/22 ,  C07D241/08 ,  C07D241/12 ,  C07D249/18 ,  C07D257/04 ,  C07D261/18 ,  C07D277/56 ,  C07D295/155 ,  C07D295/192 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/10 ,  C07D493/08 ,  C07D495/10 ,  C07D498/04 ,  C07D513/10 ,  Y02A50/30

Abstract: The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

公开(公告)号：US11760742B2

公开(公告)日：2023-09-19

申请号：US17208474

申请日：2021-03-22

Applicant: MITSUI CHEMICALS, INC.

Inventor： Kei Yoshida ,  Takeo Wakita ,  Hiroyuki Katsuta ,  Akiyoshi Kai ,  Yutaka Chiba ,  Kiyoshi Takahashi ,  Hiroko Kato ,  Nobuyuki Kawahara ,  Michikazu Nomura ,  Hidenori Daido ,  Junji Maki ,  Shinichi Banba

IPC: C07C237/42 ,  C07D333/38 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/78 ,  A01N43/80 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/30 ,  C07D241/24 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D309/08 ,  C07D309/28 ,  C07D317/62 ,  C07D333/68 ,  A01N43/40 ,  A01N37/22 ,  A01N43/60 ,  C07C237/48 ,  C07D207/34 ,  C07D239/28 ,  C07D261/18 ,  C07D307/85 ,  C07D317/46

CPC classification number: C07D333/38 ,  A01N37/22 ,  A01N37/44 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/30 ,  A01N43/40 ,  A01N43/42 ,  A01N43/54 ,  A01N43/56 ,  A01N43/58 ,  A01N43/60 ,  A01N43/78 ,  A01N43/80 ,  C07C237/42 ,  C07C237/48 ,  C07C317/40 ,  C07C323/42 ,  C07C327/48 ,  C07D207/34 ,  C07D207/416 ,  C07D213/64 ,  C07D213/73 ,  C07D213/81 ,  C07D213/82 ,  C07D213/89 ,  C07D215/52 ,  C07D231/14 ,  C07D231/16 ,  C07D239/28 ,  C07D239/30 ,  C07D241/24 ,  C07D261/18 ,  C07D263/34 ,  C07D275/03 ,  C07D277/56 ,  C07D307/24 ,  C07D307/68 ,  C07D307/84 ,  C07D307/85 ,  C07D309/08 ,  C07D309/28 ,  C07D317/46 ,  C07D317/62 ,  C07D333/68

Abstract: A compound represented by Formula (1):




The compound can be used as insecticides.

公开(公告)号：US20230271931A1

公开(公告)日：2023-08-31

申请号：US18297134

申请日：2023-04-07

Applicant: Bayer Pharma Aktiengesellschaft

Inventor： Stefan BAEURLE ,  Adam DAVENPORT ,  Christopher STIMSON ,  Jens NAGEL ,  Nicole SCHMIDT ,  Andrea ROTGERI ,  Ina GROETICKE ,  Alexandra RAUSCH ,  Juergen KLAR ,  Thomas DYRKS

IPC: C07D333/28 ,  A61P3/04 ,  A61P19/02 ,  A61P3/10 ,  A61P13/10 ,  A61P35/00 ,  C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D241/12 ,  C07D277/56 ,  C07D333/38 ,  C07D333/58 ,  C07D405/04 ,  C07D495/04

CPC classification number: C07D333/28 ,  A61P3/04 ,  A61P19/02 ,  A61P3/10 ,  A61P13/10 ,  A61P35/00 ,  C07D213/56 ,  C07D231/12 ,  C07D231/56 ,  C07D233/64 ,  C07D241/12 ,  C07D277/56 ,  C07D333/38 ,  C07D333/58 ,  C07D405/04 ,  C07D495/04

Abstract: The present invention relates to carboxylic acid aromatic amides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a diseases a sole agent or in combination with other active ingredients.

公开(公告)号：US20230183195A1

公开(公告)日：2023-06-15

申请号：US17906367

申请日：2021-03-15

Applicant: PALOBIOFARMA, S.L.

Inventor： Julio Castro PALOMINO LARIA ,  Juan CAMACHO GÓMEZ

IPC: C07D277/56 ,  A61K45/06 ,  C07C65/05 ,  C07C275/02 ,  C07D213/82

CPC classification number: C07D277/56 ,  A61K45/06 ,  C07C65/05 ,  C07C275/02 ,  C07D213/82 ,  C07B2200/13

Abstract: The present invention relates to the cocrystals of (1R,3S)-3-(5-cyano-4-phenyl-1,3-thiazol-2-ylcarbamoyl)cyclopentane carboxylic acid, a process for obtaining said cocrystals, combination products and pharmaceutical compositions comprising said cocrystals and their medical uses, in particular for the treatment or prevention of diseases known to ameliorate by A1 adenosine receptor antagonism.

公开(公告)号：US20180194733A1

公开(公告)日：2018-07-12

申请号：US15861332

申请日：2018-01-03

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Thomas A. Jordan ,  John E. Dowling ,  John Clifford Chabala

IPC: C07D215/38 ,  A61K31/4418 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D277/40 ,  C07D277/56

CPC classification number: C07D215/38 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D277/40 ,  C07D277/56

Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed

公开(公告)号：US20180127712A1

公开(公告)日：2018-05-10

申请号：US15863501

申请日：2018-01-05

Applicant: The Scripps Research Institute

Inventor： Yue Xu ,  Sheng Ding

IPC: C12N5/0735 ,  C07D417/14 ,  C07D417/12 ,  C07D239/48 ,  C07D401/14 ,  C07D401/04 ,  C07D277/56 ,  C07D403/04

CPC classification number: C12N5/0606 ,  C07D239/48 ,  C07D277/56 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D417/12 ,  C07D417/14 ,  C12N2501/999

Abstract: The present invention relates compounds for stabilizing cells and methods of their use.