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公开(公告)号:US20210207174A1
公开(公告)日:2021-07-08
申请号:US17058452
申请日:2019-05-24
Applicant: The Regents of the University of California
Inventor: Theodore Lee ROTH , Po-Yi Jonathan LI , Alexander MARSON
IPC: C12N15/90 , C07K14/725 , C07K14/715 , C07K14/705 , C12N5/0783 , A61P35/00 , A61K39/00
Abstract: Provided herein are methods and compositions for modifying an endogenous cell surface protein in a human cell by inserting a heterologous nucleic acid sequence in a target region of a nucleic acid encoding the endogenous cell surface protein.