公开(公告)号：US20210353678A1

公开(公告)日：2021-11-18

申请号：US17390673

申请日：2021-07-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander Marson ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20240392243A1

公开(公告)日：2024-11-28

申请号：US18246155

申请日：2021-10-04

Applicant: The Regents of the University of California

Inventor： Theodore Lee ROTH ,  Franziska BLAESCHKE ,  Ryan APATHY ,  Alexander MARSON ,  Yan Yi Chen

IPC: C12N5/0783 ,  A61P37/04 ,  C12N15/85 ,  C12N15/86 ,  C12N15/90

Abstract: Provided herein are methods and compositions for modifying the genome of human T cells.

公开(公告)号：US20200000851A1

公开(公告)日：2020-01-02

申请号：US16568116

申请日：2019-09-11

Applicant: The Regents of the University of California

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander MARSON ,  Cristina Puig SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C12N15/85 ,  C12N15/90 ,  C12N9/22 ,  C12N15/113 ,  C07K14/725

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20220241336A1

公开(公告)日：2022-08-04

申请号：US17725478

申请日：2022-04-20

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Theodore Lee ROTH ,  Eric SHIFRUT ,  Alexander MARSON ,  Cristina PUIG SAUS ,  Antoni RIBAS

IPC: A61K35/17 ,  C07K14/725 ,  C12N9/22 ,  C12N15/113 ,  C12N15/85 ,  C12N15/90

Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.

公开(公告)号：US20210207174A1

公开(公告)日：2021-07-08

申请号：US17058452

申请日：2019-05-24

Applicant: The Regents of the University of California

Inventor： Theodore Lee ROTH ,  Po-Yi Jonathan LI ,  Alexander MARSON

IPC: C12N15/90 ,  C07K14/725 ,  C07K14/715 ,  C07K14/705 ,  C12N5/0783 ,  A61P35/00 ,  A61K39/00

Abstract: Provided herein are methods and compositions for modifying an endogenous cell surface protein in a human cell by inserting a heterologous nucleic acid sequence in a target region of a nucleic acid encoding the endogenous cell surface protein.