公开(公告)号：US20190330365A1

公开(公告)日：2019-10-31

申请号：US16349958

申请日：2017-11-17

Applicant: The Regents of the University of California

Inventor： Bin LIU ,  Nam-Kyung LEE ,  Yang SU ,  Scott BIDLINGMAIER

IPC: C07K16/30 ,  A61K31/713 ,  C07K16/28 ,  C07K16/46

Abstract: The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition.