公开(公告)号：US20190330365A1

公开(公告)日：2019-10-31

申请号：US16349958

申请日：2017-11-17

Applicant: The Regents of the University of California

Inventor： Bin LIU ,  Nam-Kyung LEE ,  Yang SU ,  Scott BIDLINGMAIER

IPC: C07K16/30 ,  A61K31/713 ,  C07K16/28 ,  C07K16/46

Abstract: The present disclosure relates to an engineered antibody that co-engages a cell type-selective (or specific) antigen (guide) and a signaling receptor (effector) on a target cell. In some instances, the engineered antibody is capable of modulating a signaling pathway on a target cell. In other embodiments, an engineered antibody of the present disclosure is administered to a subject for the treatment of a disease or condition.

公开(公告)号：US20240254219A1

公开(公告)日：2024-08-01

申请号：US18693416

申请日：2022-09-20

Applicant: The Regents of the University of California

Inventor： Bin LIU ,  Nam-Kyung LEE ,  Scott BIDLINGMAIER ,  Yang SU

IPC: C07K16/28 ,  A61K39/00 ,  A61P19/10 ,  C12N15/10

CPC classification number: C07K16/28 ,  A61P19/10 ,  C12N15/1037 ,  C12N15/1055 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/75

Abstract: Antibodies are provided herein that agonize Wnt signaling, do not compete with a Wnt ligand for LRP6 binding, and activate Wnt signaling in the presence of inhibitors. Methods for promoting cell differentiation and tissue regeneration using the disclosed antibodies are also provided.

公开(公告)号：US20220411508A1

公开(公告)日：2022-12-29

申请号：US17639225

申请日：2020-09-09

Applicant: The Regents of the University of California

Inventor： Bin LIU ,  Shanshan LANG ,  Yang SU ,  Scott BIDLINGMAIER ,  Nam-Kyung LEE

IPC: C07K16/28

Abstract: The present disclosure relates generally to compositions and methods useful for the production of engineered antibodies having (i) multiple antigen-binding specificities and (ii) Fc regions that have been modified to promote heterodimer formation between heavy chains from antibodies with different specificities. Also provided are recombinant cells, recombinant nucleic acids encoding such engineered antibodies, as well as pharmaceutical compositions containing same.