公开(公告)号：US20220144879A1

公开(公告)日：2022-05-12

申请号：US17310821

申请日：2020-02-28

Applicant: The University of Tokyo

Inventor： Yasuteru URANO ,  Mako KAMIYA ,  Kyohei FUJITA

IPC: C07H17/06 ,  C12Q1/34 ,  G01N21/64

Abstract: A fluorescent probe is capable of detecting breast cancer, lung cancer, and squamous cell carcinoma. The fluorescent probe is also capable of detecting a benign tumor of a mammary gland. The fluorescent probe includes a compound represented by the following general formula or a salt thereof:

公开(公告)号：US20220017940A1

公开(公告)日：2022-01-20

申请号：US17298477

申请日：2019-12-02

Applicant: The University of Tokyo

Inventor： Yasuteru URANO ,  Mako KAMIYA ,  Yugo KURIKI

IPC: C12Q1/37 ,  G01N33/542 ,  G01N21/64

Abstract: A compound is represented by the following general formula (I): The compound or a salt thereof provides a fluorescent probe for detecting carboxypeptidase activity. In the formula, R1 represents an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; T represents an amino acid residue or a residue of an amino acid derivative; S represents a C-terminal amino acid residue. represents a fluorophore, and the fluorophore is a fluorophore in which an absorption/fluorescence wavelength greatly changes or a quenched state changes to a fluorescent state by elimination of the —P(═O)(—R1)-T-S moiety.

公开(公告)号：US20210072241A1

公开(公告)日：2021-03-11

申请号：US16977434

申请日：2019-03-04

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Yasuteru URANO ,  Mako KAMIYA ,  Minoru KAWATANI ,  Hirohisa IWAKI ,  Kyoko YAMAMOTO ,  Haruki KUME ,  Daisuke YAMADA

IPC: G01N33/573 ,  G01N33/574 ,  C07D493/10 ,  C07D311/90

Abstract: A fluorescent probe can be used to detect and visualize carboxypeptidase activity with high sensitivity. The fluorescent probe has, as a base nucleus, a fluorescent skeleton that functions in the visible light region, and makes carboxypeptidase activity detectable and visible, for example, within a cell or clinical specimen, with high sensitivity.

公开(公告)号：US20170157272A1

公开(公告)日：2017-06-08

申请号：US15324147

申请日：2015-07-10

Applicant: The University of Tokyo

Inventor： Yasuteru URANO ,  Yasuyuki SETO ,  Haruna ONOYAMA ,  Yugo KURIKI ,  Mako KAMIYA

IPC: A61K49/00 ,  A61B1/04

CPC classification number: A61K49/0041 ,  A61B1/043 ,  A61K49/00 ,  C12M1/00

Abstract: [Problem] To provide a novel fluorescent probe for dipeptidyl peptidase IV, and a detection method and a detection kit using the fluorescent probe.[Solution] A fluorescent probe for detecting dipeptidyl peptidase IV (DPP-IV), said probe comprising a compound represented by formula (I) or a salt, thereof. In formula (I): A and B are either the same or different and independently represent an amino acid residue, provided that A is bonded via an amide bond to NH in an adjacent formula and B is bonded via an amide bond to A; R1 represents hydrogen atom(s) or 1 to 4 substituents bonded to the benzene ring, said substituents being either the same or different; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; and X represents a C1-C5 alkylene group.