公开(公告)号：US20170157272A1

公开(公告)日：2017-06-08

申请号：US15324147

申请日：2015-07-10

Applicant: The University of Tokyo

Inventor： Yasuteru URANO ,  Yasuyuki SETO ,  Haruna ONOYAMA ,  Yugo KURIKI ,  Mako KAMIYA

IPC: A61K49/00 ,  A61B1/04

CPC classification number: A61K49/0041 ,  A61B1/043 ,  A61K49/00 ,  C12M1/00

Abstract: [Problem] To provide a novel fluorescent probe for dipeptidyl peptidase IV, and a detection method and a detection kit using the fluorescent probe.[Solution] A fluorescent probe for detecting dipeptidyl peptidase IV (DPP-IV), said probe comprising a compound represented by formula (I) or a salt, thereof. In formula (I): A and B are either the same or different and independently represent an amino acid residue, provided that A is bonded via an amide bond to NH in an adjacent formula and B is bonded via an amide bond to A; R1 represents hydrogen atom(s) or 1 to 4 substituents bonded to the benzene ring, said substituents being either the same or different; R2, R3, R4, R5, R6 and R7 independently represent a hydrogen atom, a hydroxyl group, an alkyl group or a halogen atom; R8 and R9 independently represent a hydrogen atom or an alkyl group; and X represents a C1-C5 alkylene group.