公开(公告)号：US5023089A

公开(公告)日：1991-06-11

申请号：US379631

申请日：1989-07-13

申请人： Teruo Sakamoto ,  Toyohiko Takeda ,  Yusuke Suzuki

发明人： Teruo Sakamoto ,  Toyohiko Takeda ,  Yusuke Suzuki

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/22 ,  A61K9/50

CPC分类号： A61K9/1617 ,  A61K9/5073

摘要： Sustained-release preparations essentially consisting of 1 part by weight of a water-soluble active ingredient and 1 to 10 parts by weight of two or more fats where the melting point is different in one from others, being capable of releasing active ingredients at a constant rate for a long-period of time, and being manufactured easily and economically.

公开(公告)号：US4720387A

公开(公告)日：1988-01-19

申请号：US617567

申请日：1984-06-05

申请人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Toshihiro Ogura

发明人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Toshihiro Ogura

IPC分类号： C07D213/75 ,  A61K9/00 ,  A61K9/36 ,  A61K9/50 ,  A61K9/62 ,  A61K31/44 ,  A61K31/4409 ,  A61K9/24

CPC分类号： A61K31/44 ,  A61K9/5084

摘要： Highly effective and orally administrable sustained-release preparation of an antihypertensive agent, pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) comprising a rapid-release and a slow-release component at a ratio of about 7:3 to about 1:9 by pinacidil weight.

摘要翻译： 高效口服给药的抗高血压药缓释制剂，包含快速释放组分和缓释组分的pinacidil（N“ - 氰基-N-4-吡啶基-N'-1,2,2-三甲基丙基胍） 其比例为约7:3至约1:9。