公开(公告)号：US5026835A

公开(公告)日：1991-06-25

申请号：US447512

申请日：1989-12-07

申请人： Tohru Ueda ,  Takuma Sasaki ,  Akira Matsuda ,  Takanori Miyashita ,  Shinji Sakata ,  Keiji Yamagami ,  Akihiro Fujii

发明人： Tohru Ueda ,  Takuma Sasaki ,  Akira Matsuda ,  Takanori Miyashita ,  Shinji Sakata ,  Keiji Yamagami ,  Akihiro Fujii

IPC分类号： C07H19/06

CPC分类号： C07H19/06

摘要： Pyrimidine 2'-deoxy-2'-methylidene nucleoside compounds: ##STR1## wherein R.sup.1 represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R.sup.2 represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R.sup.3 and R.sup.4 represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R.sup.1 is amino or hydroxy, and both of R.sup.3 and R.sup.4 are hydrogen.Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.