公开(公告)号：US11304911B2

公开(公告)日：2022-04-19

申请号：US17473863

申请日：2021-09-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Qiang Cheng ,  Tuo Wei ,  Daniel J. Siegwart

IPC: C07H21/02 ,  C07H21/04 ,  A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.

公开(公告)号：US11229609B2

公开(公告)日：2022-01-25

申请号：US17191895

申请日：2021-03-04

Applicant: The Board of Regents of the University of Texas System

Inventor： Qiang Cheng ,  Tuo Wei ,  Daniel J. Siegwart

IPC: C07H21/02 ,  C07H21/04 ,  A61K9/51 ,  A61K48/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.